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ADAMTS5 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. 再加上，我们可以发ADAMTS5 试剂盒 (39) 和 ADAMTS5 蛋白 (9)和数多这个蛋白质的别的产品。
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Adamts5(-/-) mice were protected from hepatic mitochondrial dysfunction, as indicated by increased mitochondrial respiratory chain complex activity, higher ATP levels and higher expression of antioxidant enzymes. Absence of ADAMTS5 preserves liver integrity in a diet-induced obesity model.
research emphasises the importance of ADAMTS5 expression in the control of influenza virus infection and highlights the potential for development of ADAMTS5-based therapeutic strategies to reduce morbidity and mortality
TS5 protein functions to suppress glucose uptake in adipose-derived stromal cells and thereby inhibits the synthesis, and promotes the intracellular degradation of Acan (显示 ACAN 抗体) and Vcan (显示 Vcan 抗体) by an ADAMTS (显示 ADAMTS1 抗体) other than TS5.
Data suggest that ADAMTS-5 oligomerization is required for full aggrecanase (显示 ADAMTS4 抗体) activity in vitro and in situ (as seen in knee joint of mouse model of inflammatory arthritis); thus, blocking oligomerization inhibits ADAMTS-5 activity.
aggrecan (显示 ACAN 抗体) and brevican (显示 BCAN 抗体) proteolysis is compensated in Adamts4 (显示 ADAMTS4 抗体)-/- or Adamts5-/- mice by ADAMTS (显示 ADAMTS1 抗体) proteoglycanase (显示 MMP3 抗体) family members but a threshold of versican (显示 Vcan 抗体) proteolysis is sensitive to the loss of a single ADAMTS (显示 ADAMTS1 抗体) proteoglycanase (显示 MMP3 抗体) during spinal cord injury
The present study reveals ADAMT-5 expression by mast cells(MCs (显示 SMCP 抗体)) and that MC activation regulates the expression of the protease, thus implicating the ADAMT-5 of protease in MC function.
Western blot analyses indicated that aggrecanase (显示 ADAMTS4 抗体)-generated proteoglycan (显示 Vcan 抗体) fragments are produced after SCI.
RelA/p65 (显示 NFkBP65 抗体) is a potent transcriptional activator of ADAMTS5 in chondrocytes during osteoarthritis development.
Repair of biomechanically compromised tendons exhibiting midsubstance chondroid accumulation requires ADAMTS5.
this study identified, for the first time, several genes that have an ADAMTS-5-independent role in osteoarthritis(OA), identifying them as possible OA initiation candidates.
The IL1B (显示 IL1B 抗体)/AP-1 (显示 FOSB 抗体)/miR (显示 MLXIP 抗体)-30a/ADAMTS-5 axis regulates cartilage matrix degradation in osteoarthritis.
The findings suggest that miR (显示 MLXIP 抗体)-140 suppresses colorectal cancer progression and metastasis, possibly through downregulating ADAMTS5 and IGFBP5 (显示 IGFBP5 抗体).
Results provide direct evidence indicating that Fibulin-2 (显示 FBLN2 抗体) is a novel substrate of ADAMTS-5 and that this proteolysis could alter the cellular microenvironment affecting the balance between protumor and antitumor effects associated to both Fibulin-2 (显示 FBLN2 抗体) and the ADAMTSs metalloproteases.
Endoplasmic reticulum stress participates in the progress of senescence and apoptosis of osteoarthritic chondrocytes, which manifested in increased expression of ADAMTS5, MMP13 (显示 MMP13 抗体), and decreased COL2A1 (显示 COL2A1 抗体) expression.
Single Nucleotide Variants of Candidate Genes in Aggrecan (显示 ACAN 抗体) Metabolic Pathway Are Associated with Lumbar Disc Degeneration and Modic Changes
RREB1 (显示 RREB1 抗体) cooperates with noncoding RNA linc-ADAMTS5 to inhibit ADAMTS5 expression, thereby affecting degeneration of the extracellular matrix (ECM (显示 MMRN1 抗体)) of the intervertebral disc.
Matrilin 2 (显示 MATN2 抗体) accumulation associated with relative ADAMTS5 deficiency may contribute to the mechanism underlying calcific aortic valve disease progression.
In osteoarthritis (OA) chondrocytes, hydrostatic pressure (HP) restores the expression levels of some miRNAs, downregulates MMP-13 (显示 MMP13 抗体), ADAMTS-5, and HDAC-4 (显示 HDAC4 抗体), and modulates the Wnt (显示 WNT2 抗体)/beta-catenin (显示 CTNNB1 抗体) pathway activation.
we investigated whether important polymorphisms in the ADAMTS4 (显示 ADAMTS4 抗体) and ADAMTS5 genes affect osteoarthritis (OA) susceptibility. ADAMTS4 (显示 ADAMTS4 抗体) and ADAMTS5 genotypes were determined using the ABI Prism StepOnePlus Real-Time system. Our findings suggest that the ADAMTS4 (显示 ADAMTS4 抗体) (rs4233367 and rs11807350) and ADAMTS5 (rs226794 and rs2830585) variants examined may not contribute to susceptibility to knee OA in the Turkish population.
Increased ADAMTS5 levels were observed in placental insufficiency cases.
The delayed activation of proMMPs and the relatively low cleavage efficiency of MMPs compared to ADAMTS5 (aggrecanase (显示 ADAMTS4 抗体)) explains the minor contribution of the MMP enzymes to aggrecan (显示 ACAN 抗体) catabolism in vivo.
ADAMTS4 (显示 ADAMTS4 抗体) and ADAMTS5 are inhibited by alpha2-macroglobulin (显示 A2M 抗体)
identified multiple conserved amino acids within regions N- and C-terminal to the site of scission that may influence enzyme-substrate recognition, and may interact with exosites on ADAMTS-4 (显示 ADAMTS4 抗体) and ADAMTS-5
Co-culture of mechanically injured cartilage with joint capsule tissue alters chondrocyte expression patterns and increases ADAMTS5 production.
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage.
ADAM metallopeptidase with thrombospondin type 1 motif, 5
, a disintegrin and metalloproteinase with thrombospondin motifs 5-like
, A disintegrin and metalloproteinase with thrombospondin motifs 5
, ADAM-TS 5
, a disintegrin and metalloproteinase with thrombospondin motifs 11
, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)
, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5
, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)