1-Acylglycerol-3-Phosphate O-Acyltransferase 2 (Lysophosphatidic Acid Acyltransferase, Beta) (AGPAT2) ELISA试剂盒

AGPAT2 encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. 再加上,我们可以发AGPAT2 抗体 (61)AGPAT2 蛋白 (4)和数多这个蛋白质的别的产品。

list all ELISA KIts 基因 基因ID UniProt
AGPAT2 10555 O15120
AGPAT2 311821  
AGPAT2 67512 Q8K3K7
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1.0 ng/mL 10-250 ng/mL   96 Tests 15至18个工作日
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豚鼠 1.0 ng/mL 10-250 ng/mL   96 Tests 15至18个工作日
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Cow 1.0 ng/mL 10-250 ng/mL   96 Tests 15至18个工作日
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大鼠 1.0 ng/mL 10-250 ng/mL   96 Tests 15至18个工作日
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1.0 ng/mL 10-250 ng/mL   96 Tests 15至18个工作日
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小鼠 1.0 ng/mL 10-250 ng/mL   96 Tests 15至18个工作日
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1.0 ng/mL 10-250 ng/mL   96 Tests 15至18个工作日
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1.0 ng/mL 10-250 ng/mL   96 Tests 15至18个工作日
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Pig
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适于 AGPAT2 相互作用对的更多 ELISA 试剂盒

Human 1-Acylglycerol-3-Phosphate O-Acyltransferase 2 (Lysophosphatidic Acid Acyltransferase, Beta) (AGPAT2) interaction partners

  1. The findings demonstrate that AGPAT2, which is mutated in patients with congenital generalized lipodystrophy and over-expressed in different types of cancer, is a direct transcriptional target of HIF-1, suggesting that upregulation of lipid storage by HIF-1 plays an important role in adaptation and survival of cancer cells under low oxygen conditions.

  2. Results show that LPAATbeta had high expression in osteosarcoma patients who received cisplatin treatment and cisplatin-resistant cancer cell lines. In vitro and in vivo studies provide evidence that LPAATB plays an important role in osteosarcoma.

  3. Data show that missense mutation c.299G>A changes serine in the acyltransferase NHX4D motif of AGPAT2, and intronic c.493-1G>C mutation destroy a splicing site that leads to exon 4 skipping and deletion of whole AGPAT2 substrate binding domain.

  4. the ability of LPAAT-beta to regulate mTOR function

  5. miR-24 may play an important role in inhibiting osteosarcoma growth through suppression of LPAATbeta.

  6. novel nonsense a missense mutations were found in two patients with congenital generalized lipodystrophy type 1.

  7. Data suggest that AGPAT2 regulates adipogenesis through modulation of lipid metabolism/signal transduction, altering normal activation of phosphatidylinositol 3-kinase (PI3K)/protooncogene c-Akt and PPARgamma signaling in early stage of adipogenesis.

  8. the role of AGPAT1 or AGPAT2 in liver lipogenesis is minimal and that accumulation of liver fat is primarily a consequence of insulin resistance

  9. lpaat beta gene overexpression exists in both AML and CML patients. lpaat beta produced by AML cells probably plays an important role in abnormal proliferation and drug-resistance of AML cells.

  10. Lysophosphatidic acid acyltransferase beta (LPAATbeta) promotes the tumor growth of human osteosarcoma

  11. AGPAT2 is mutated in congenital generalized lipodystrophy linked to chromosome 9q34.

  12. Congenital lipodystrophy patients with Seipin mutations have a more severe lack of body fat, which affects both metabolically active and mechanical adipose tissue, compared with patients with mutations in the AGPAT2 gene.

  13. mutations in AGPAT2 and Gng3lg are approximately equally represented in congenital generalized lipodystrophy

  14. reduction in AGPAT2 enzymatic activity underlies the loss of adipose tissue in congenital generalized lipodystrophy

  15. Our study shows that LPAAT-beta is upregulated in ovarian cancer and is more prevalent in poorly differentiated tumours

  16. mutations in AGPAT2 or Seipin may have roles in Berardinelli-Seip congenital lipodystrophy

  17. Berardinelli-Seip syndrome is a congenital form of generalized lipodystrophy, transmitted as an autosomal recessive trait. It is well documented in medicine and skin. It is a rare disorder caused by mutations of AGPAT2 gene or BSCL2 gene.

  18. A new subtype of congenital generalized lipodystrophy is not associated with the AGPAT2 gene.

  19. We have demonstrated four novel mutations of the BSCL2 and AGPAT2 genes responsible for Berardinelli-Seip syndrome and Brunzell syndrome (AGPAT2-related syndrome).

  20. Study showed that the cellular level of lysophosphatidic acid was increased in AGPAT2 deficient cells.

Cow (Bovine) 1-Acylglycerol-3-Phosphate O-Acyltransferase 2 (Lysophosphatidic Acid Acyltransferase, Beta) (AGPAT2) interaction partners

  1. Data indicate that the longissimus dorsi muscle (LM) of steers showed higher G0/G1 switch gene 2 (G0S2) and comparative gene identification-58 (CGI-58) mRNA expression levels than the LM of bulls.

Mouse (Murine) 1-Acylglycerol-3-Phosphate O-Acyltransferase 2 (Lysophosphatidic Acid Acyltransferase, Beta) (AGPAT2) interaction partners

  1. Adipogenically induced Agpat2(-/-) preadipocytes had fewer lipid-loaded cells and lower levels of adipocyte markers than wild type preadipocytes.

  2. Leptin ameliorates insulin resistance and hepatic steatosis in Agpat2-/- lipodystrophic mice independent of hepatocyte leptin receptors

  3. The lack of normal insulin signaling in Agpat2(-/-) livers allows unrestricted phosphatidic acid-induced gluconeogenesis.

  4. Data suggest that Agpat2 regulates adipogenesis through modulation of lipid metabolism/signal transduction, altering normal activation of phosphatidylinositol 3-kinase (PI3K)/protooncogene c-Akt and PPARgamma signaling in early stage of adipogenesis.

  5. the role of AGPAT1 or AGPAT2 in liver lipogenesis is minimal and that accumulation of liver fat is primarily a consequence of insulin resistance

  6. Loss of adipocytes by necrosis and apoptosis in Agpat2 null mice

  7. There is a prevalence of mutations in this enzymes among human lipodystrophies

  8. mAGPAT 1, 2, and 3 mRNA levels increased rapidly in mouse skin after acute permeability barrier disruption

  9. impaired AGPAT2 activity affects availability of phosphatidic acid (PA) for triacylglycerol synthesis but not overall PA synthesis nor utilization of PA for phospholipid synthesis

  10. The alternative monoacylglycerol pathway for triglyceride biosynthesis is activated in the absence of 1-acylglycerol-3-phosphate O-acyltransferase 2.

AGPAT2 抗原简介

Antigen Summary

This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. The protein is located within the endoplasmic reticulum membrane and converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. Mutations in this gene have been associated with congenital generalized lipodystrophy (CGL), or Berardinelli-Seip syndrome, a disease characterized by a near absence of adipose tissue and severe insulin resistance. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Gene names and symbols associated with AGPAT2

  • 1-acylglycerol-3-phosphate O-acyltransferase 2 (AGPAT2) 抗体
  • 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta) (agpat2) 抗体
  • 1-acylglycerol-3-phosphate O-acyltransferase 2 (agpat2) 抗体
  • 1-acylglycerol-3-phosphate O-acyltransferase 2 (Agpat2) 抗体
  • 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta) (Agpat2) 抗体
  • 1-AGPAT2 抗体
  • 2510002J07Rik 抗体
  • AGPAT2 抗体
  • AV000834 抗体
  • BSCL 抗体
  • BSCL1 抗体
  • LPAAB 抗体
  • LPAAT-beta 抗体
  • zgc:153984 抗体

Protein level used designations for AGPAT2

1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta) , 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha , 1-AGP acyltransferase 2 , 1-AGPAT 2 , 1-acyl-sn-glycerol-3-phosphate acyltransferase beta , lysophosphatidic acid acyltransferase beta , lysophosphatidic acid acyltransferase-beta , lysophosphatidic acid acyltransferase, beta

GENE ID SPECIES
709753 Macaca mulatta
748669 Pan troglodytes
772114 Gallus gallus
777624 Danio rerio
100170486 Xenopus (Silurana) tropicalis
10555 Homo sapiens
311821 Rattus norvegicus
491249 Canis lupus familiaris
100170768 Sus scrofa
512112 Bos taurus
67512 Mus musculus
101114511 Ovis aries
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