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AGPAT2 encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. 再加上，我们可以发AGPAT2 抗体 (47) 和 AGPAT2 蛋白 (4)和数多这个蛋白质的别的产品。
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Data show that missense mutation c.299G>A changes serine in the acyltransferase NHX4D motif of AGPAT2, and intronic c.493-1G>C mutation destroy a splicing site that leads to exon 4 skipping and deletion of whole AGPAT2 substrate binding domain.
the ability of LPAAT-beta to regulate mTOR (显示 FRAP1 ELISA试剂盒) function
miR-24 may play an important role in inhibiting osteosarcoma growth through suppression of LPAATbeta.
Data suggest that AGPAT2 regulates adipogenesis through modulation of lipid metabolism/signal transduction, altering normal activation of phosphatidylinositol 3-kinase (PI3K (显示 PIK3CA ELISA试剂盒))/protooncogene c-Akt (显示 AKT1 ELISA试剂盒) and PPARgamma (显示 PPARG ELISA试剂盒) signaling in early stage of adipogenesis.
the role of AGPAT1 (显示 AGPAT1 ELISA试剂盒) or AGPAT2 in liver lipogenesis is minimal and that accumulation of liver fat is primarily a consequence of insulin (显示 INS ELISA试剂盒) resistance
lpaat beta gene overexpression exists in both AML (显示 RUNX1 ELISA试剂盒) and CML (显示 BCR ELISA试剂盒) patients. lpaat beta produced by AML (显示 RUNX1 ELISA试剂盒) cells probably plays an important role in abnormal proliferation and drug-resistance of AML (显示 RUNX1 ELISA试剂盒) cells.
Lysophosphatidic acid acyltransferase beta (LPAATbeta) promotes the tumor growth of human osteosarcoma
AGPAT2 is mutated in congenital generalized lipodystrophy linked to chromosome 9q34.
Congenital lipodystrophy patients with Seipin (显示 BSCL2 ELISA试剂盒) mutations have a more severe lack of body fat, which affects both metabolically active and mechanical adipose tissue, compared with patients with mutations in the AGPAT2 gene.
mutations in AGPAT2 and Gng3lg (显示 BSCL2 ELISA试剂盒) are approximately equally represented in congenital generalized lipodystrophy
Data indicate that the longissimus dorsi muscle (LM) of steers showed higher G0/G1 switch gene 2 (G0S2) and comparative gene identification-58 (CGI-58) mRNA expression levels than the LM of bulls.
Adipogenically induced Agpat2(-/-) preadipocytes had fewer lipid-loaded cells and lower levels of adipocyte markers than wild type preadipocytes.
Leptin (显示 LEP ELISA试剂盒) ameliorates insulin (显示 INS ELISA试剂盒) resistance and hepatic steatosis in Agpat2-/- lipodystrophic mice independent of hepatocyte leptin (显示 LEP ELISA试剂盒) receptors
The lack of normal insulin (显示 INS ELISA试剂盒) signaling in Agpat2(-/-) livers allows unrestricted phosphatidic acid-induced gluconeogenesis.
Data suggest that Agpat2 regulates adipogenesis through modulation of lipid metabolism/signal transduction, altering normal activation of phosphatidylinositol 3-kinase (PI3K)/protooncogene c-Akt (显示 AKT1 ELISA试剂盒) and PPARgamma (显示 PPARG ELISA试剂盒) signaling in early stage of adipogenesis.
Loss of adipocytes by necrosis and apoptosis in Agpat2 null mice
impaired AGPAT2 activity affects availability of phosphatidic acid (PA) for triacylglycerol synthesis but not overall PA synthesis nor utilization of PA for phospholipid synthesis
The alternative monoacylglycerol pathway for triglyceride biosynthesis is activated in the absence of 1-acylglycerol-3-phosphate O-acyltransferase 2.
This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. The protein is located within the endoplasmic reticulum membrane and converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. Mutations in this gene have been associated with congenital generalized lipodystrophy (CGL), or Berardinelli-Seip syndrome, a disease characterized by a near absence of adipose tissue and severe insulin resistance. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)
, 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha
, 1-AGP acyltransferase 2
, 1-AGPAT 2
, 1-acyl-sn-glycerol-3-phosphate acyltransferase beta
, lysophosphatidic acid acyltransferase beta
, lysophosphatidic acid acyltransferase-beta
, lysophosphatidic acid acyltransferase, beta