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High expression of TCF7 is associated with osteosarcoma.
Findings indicate that breast cancer cells with a hyperactive AF1q (显示 MLLT11 ELISA试剂盒)/TCF7/CD44 (显示 CD44 ELISA试剂盒) regulatory axis in the primary sites may represent "metastatic founder cells" which have invasive properties.
TCF7 plays critical roles in lung diseases [review]
Tcf7 levels are lower in islets taken from patients with type 2 diabetes. Knockdown of TCF7 in islets impairs the cytoprotective respo (显示 GIP ELISA试剂盒)nsiveness to GIP and enhances the magnitude of apoptotic injury.
Capsaicin-induced apoptosis in pancreatic cancer cells was associated with inhibition of beta-catenin (显示 CTNNB1 ELISA试剂盒) signaling due to the dissociation of beta-catenin (显示 CTNNB1 ELISA试剂盒)/TCF-1 (显示 HNF1A ELISA试剂盒) complex and the process was orchestrated by STAT-3 (显示 STAT3 ELISA试剂盒).
we show that TCF7 is a direct target of miR (显示 MLXIP ELISA试剂盒)-34a in prostate cancer that has metastasized to the bone
induction of expression activates the Wnt (显示 WNT2 ELISA试剂盒) signaling pathway, leading to priming of liver cancer stem cells self-renewal and tumor propagation
RUNX2 (显示 RUNX2 ELISA试剂盒) signaling pathways with their partners TCF7 and FGFR1 (显示 FGFR1 ELISA试剂盒)/2 may not be involved in CCD (显示 RUNX2 ELISA试剂盒) pathogenesis
Results suggest ivermectin as therapeutic WNT protein-TCF (显示 HNF4A ELISA试剂盒) transcription factor pathway response blocker to treat WNT (显示 WNT2 ELISA试剂盒)-TCF (显示 HNF4A ELISA试剂盒)-dependent diseases including multiple cancers.
miRNAs inhibited the expression of the luciferase reporter constructs containing 3'UTRs of these genes and downregulated protein expression of TERT (显示 TERT ELISA试剂盒) and the TCF7 transcription factor, which mediates the canonical Wnt (显示 WNT2 ELISA试剂盒) pathway.
data reveal that T cell factor 1 (Tcf1) long and short isoforms have distinct, yet complementary, functions and may represent an evolutionarily conserved means to ensure proper programming of CD8 (显示 CD8A ELISA试剂盒)(+) and CD4 (显示 CD4 ELISA试剂盒)(+) T cell responses to viral infection
Tcf7 levels are lower in islets taken from diabetic mice. Knockdown of TCF7 in islets impairs the cytoprotective responsiveness to GIP (显示 GIP ELISA试剂盒) and enhances the magnitude of apoptotic injury.
TCF-1-deficient CD4+ CD8+ double positive thymocytes fail to undergo TCR alpha Valpha14-Jalpha18 rearrangement and produce significantly fewer Natural killer T cells.
The data suggest that miR (显示 MLXIP ELISA试剂盒)-24 participates in osteogenic differentiation by targeting and regulating Tcf-1 (显示 HNF1A ELISA试剂盒) expression in osteoblastic cells.
this study proposes a regulatory role for TCF7 in limiting access to the Treg lineage
Our results support a critical role for miR (显示 MLXIP ELISA试剂盒)-22-3p and its target, Tcf7, in the pathogenesis of diabetes by upregulating gluconeogenesis.
TCF-1 (显示 HNF1A ELISA试剂盒) was essential for both the initiation of T(FH) differentiation and the effector function of differentiated T(FH) cells during acute viral infection. TCF-1 (显示 HNF1A ELISA试剂盒) promoted Bcl-6 (显示 BCL6 ELISA试剂盒) expression but repressed Blimp1 (显示 PRDM1 ELISA试剂盒) expression.
Chromatin immunoprecipitation sequencing revealed the transcription factor Tcf7 and the chemokine receptor Ccr7 (显示 CCR7 ELISA试剂盒) as Foxo1 (显示 FOXO1 ELISA试剂盒)-bound target genes, which have critical functions in central-memory T cell differentiation and trafficking.
Our data support that the loss of Tcf7 diminishes hematopoietic stem cell function.
TCF-1 (显示 HNF1A ELISA试剂盒) mediates repression of Notch (显示 NOTCH1 ELISA试剂盒) pathway in T lineage-committed early thymocytes.
The protein encoded by this gene is a transcriptional activator that plays an important role in lymphocyte differentiation. This gene is expressed predominantly in T-cells. The encoded protein can bind an enhancer element and activate the CD3E gene, and it also may repress the CTNNB1 and TCF7L2 genes through a feedback mechanism. Several transcript variants encoding different isoforms have been found for this gene.
T-cell-specific transcription factor 1
, transcription factor 7
, transcription factor 7, T-cell specific
, T cell factor-1
, T-cell factor 1