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Enhancer of zeste homolog 2 (EZH2 (显示 EZH2 ELISA试剂盒)) expression is positively correlated with the expression of Wnt (显示 WNT2 ELISA试剂盒)/beta-catenin (显示 CTNNB1 ELISA试剂盒) signaling and negatively correlated with the expression of GSK-3beta and TP53 (显示 TP53 ELISA试剂盒) in cervical cancer tissues.
ZIP9 (显示 SLC39A9 ELISA试剂盒) expression affects phosphorylation states of GSK-3beta.
High GSK3 expression is associated with prostate cancer.
Cytoplasmic aryl hydrocarbon receptor (显示 AHR ELISA试剂盒) regulates glycogen synthase kinase 3 beta in non-small cell lung cancer cells.
Findings show that FGF19 (显示 FGF19 ELISA试剂盒) provides a cytoprotective role against ER stress by activating a FGFR4 (显示 FGFR4 ELISA试剂盒)-GSK3beta-Nrf2 (显示 GABPA ELISA试剂盒) signaling cascade, suggesting targeting this signaling node as a candidate therapeutic regimen for hepatocellular carcinoma (HCC (显示 FAM126A ELISA试剂盒)) management.
data show that the GSK3B-FOXO3 (显示 FOXO3 ELISA试剂盒) pathway is activated after partial hepatectomy, and this may be one of the mechanisms that lead to upregulation of hepatic IGF1R (显示 IGF1R ELISA试剂盒) after partial hepatectomy.
ablation of Glut1 (显示 SLC2A1 ELISA试剂盒) attenuated apoptosis and increased drug resistance via upregulation of p-Akt (显示 AKT1 ELISA试剂盒)/p-GSK-3beta (Ser9)/beta-catenin (显示 CTNNB1 ELISA试剂盒)/survivin (显示 BIRC5 ELISA试剂盒).
frequent upregulation of MIF (显示 AMH ELISA试剂盒) is implicated in the development and progression of esophageal squamous cell carcinoma (ESCC).
TRIM9s undergoes Lys (显示 LYZ ELISA试剂盒)-63-linked auto-polyubiquitination and serves as a platform to bridge GSK3beta to TBK1 (显示 TBK1 ELISA试剂盒), leading to the activation of IRF3 (显示 IRF3 ELISA试剂盒) signaling.
Data suggest that NOX5 (显示 NOX5 ELISA试剂盒) expression in melanoma cells could contribute to cell proliferation due, in part, to the generation of high local concentrations of extracellular ROS (显示 ROS1 ELISA试剂盒) that modulate multiple pathways that regulate HIF-1alpha (显示 HIF1A ELISA试剂盒) and networks that signal through Akt (显示 AKT1 ELISA试剂盒)/GSK3beta/p27(Kip1 (显示 CDKN1B ELISA试剂盒)) .
This study demonstrates the neuroprotective effect of TSG (显示 TWSG1 ELISA试剂盒) on APP (显示 APP ELISA试剂盒) expression, suggesting that TSG (显示 TWSG1 ELISA试剂盒) may be beneficial for AD prevention and treatment.
GSK3 catalyzes two previously unreported phosphorylation events at Ser(476) and Ser(480) of Cbl-b. The PI3K-PKB-GSK-3 pathway is a novel regulatory axis that is important for controlling the decision between T cell activation and tolerance via Cbl-b.
GSK-3 plays a significant role in astrocyte development and behavioral control in mice.
Study of GSK3b inhibitors SB415286 and SB216763 to improve osteoblastic differentiation on microstructured titanium.
identify GSK-3beta as a newly identified target for amelioration of empyema-related pleural fibrosis and provide a strong rationale for further investigation of GSK-3beta signaling in the control of MesoMT and pleural injury
it is suggested that Notch-1 (显示 NOTCH1 ELISA试剂盒), NF-kappaB (显示 NFKB1 ELISA试剂盒)/p65 (显示 NFkBP65 ELISA试剂盒) and GSK-3beta operate in synergy to inhibit microglia activation
Data suggest that, in embryonic stem cells, Gsk3b/Gsk3a (显示 GSK3a ELISA试剂盒) phosphorylate splicing factors (Rbm8a (显示 RBM8A ELISA试剂盒), Srsf9 (显示 SFRS9 ELISA试剂盒), and Psf (显示 IL-3 ELISA试剂盒)) and nucleolar proteins (Npm1 (显示 GJA1 ELISA试剂盒) and Phf6 (显示 PHF6 ELISA试剂盒)); Gsk3b/Gsk3a (显示 GSK3a ELISA试剂盒) are key to alternative splicing of close to 190 genes. (Gsk3 = glycogen synthase kinase-3 (显示 GSK3a ELISA试剂盒); Rbm8a (显示 RBM8A ELISA试剂盒) = RNA binding motif protein 8a (显示 RBM8A ELISA试剂盒); Srsf9 (显示 SFRS9 ELISA试剂盒) = splicing factor (显示 SLU7 ELISA试剂盒), arginine-serine-rich 9; Psf (显示 IL-3 ELISA试剂盒) = replication protein Psf (显示 IL-3 ELISA试剂盒); Npm1 (显示 GJA1 ELISA试剂盒) = nucleophosmin 1 (显示 NPM1 ELISA试剂盒); Phf6 (显示 PHF6 ELISA试剂盒) = PHD finger protein 6 (显示 PHF6 ELISA试剂盒))
Tideglusib significantly reduced cerebral infarct volume at both 24h and 7days after HI injury. Tideglusib also increased phosphorylated GSK-3beta(Ser9) and Akt (显示 AKT1 ELISA试剂盒)(Ser473)
Therefore our study identifies a compartmentalized PtdIns(3,4,5)P3/AKT (显示 AKT1 ELISA试剂盒)/GSK3beta signaling axis at cilia in SHH (显示 SHH ELISA试剂盒)-dependent medulloblastoma that is regulated by INPP5E (显示 INPP5E ELISA试剂盒) to maintain tumor cell cilia, promote SHH (显示 SHH ELISA试剂盒) signaling and thereby medulloblastoma progression.
These results suggest that maintenance of sperm motility and acrosome reaction timing are mediated by PKA through the regulation of GSK-3 beta activity.
GSK3B and phosphorylated GSK3B regulate milk synthesis and proliferation dairy cow mammary epithelial cells.
GSK3B serine phosphorylation was positively correlated with embryo development
results suggest that Nav1.7-Ca2+ influx-protein kinase C-alpha pathway activated ERK1/ERK2 and p38, which increased phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation
IGF-I (显示 IGF1 ELISA试剂盒) down-regulated functional IGF-I receptor (显示 IGF1R ELISA试剂盒) via GSK-3beta inhibition and mTOR (显示 FRAP1 ELISA试剂盒) activation; constitutive activity of GSK-3beta maintained IGF-I receptor (显示 IGF1R ELISA试剂盒) level in nonstimulated cells.
These results suggest that phospholipids and sulfatide and heparin may function as effective stimulators for autophosphorylation of GSK-3beta and for the GSK-3beta-mediated phosphorylation of SH-binding proteins, including MBP (显示 MBP ELISA试剂盒) and tau protein.
cAMP/PKA regulation of GSK3beta/beta-catenin (显示 CTNNB1 ELISA试剂盒) signaling contributes to the increase in progesterone production in corpus luteum.
Five different isoforms of GSK3beta identified from porcine tissues, splice variants exhibit differential activity towards glycogen synthase.
scratching-induced injury and repair of bronchial epithelial cells may involve inhibition of GSK3beta activity which can lead to activation of the downstream signaling through beta-catenin (显示 CTNNB1 ELISA试剂盒)
There was no correlation of infarct size with expression or phosphorylation of p70S6K (显示 RPS6KB1 ELISA试剂盒) or GSK3beta in ischemic postconditioning.
Both active and inactive forms of Gsk3b mediate the cooperative signaling during angiogenesis in zebrafish embryos.
a novel negative, Gsk3beta-independent control mechanism of beta-catenin and implicates Ccr7 as a long-hypothesized GPCR regulating vertebrate axis formation.
The regulatory target of Wnts and Igfs, GSK3beta, is inefficiently inactivated in male fin regenerates compared with females. Pharmacological inhibition of GSK3 in males increases blastemal proliferation and restores regenerative pattern.
2-OST (显示 HS2ST1 ELISA试剂盒) functions within the Wnt (显示 WNT2 ELISA试剂盒) pathway, downstream of Wnt (显示 WNT2 ELISA试剂盒) ligand signaling and upstream of Gsk3beta and beta-catenin (显示 CTNNB1 ELISA试剂盒) intracellular localization and function
Data show that GSK-3beta inhibition was sufficient to stimulate MG dedifferentiation and the formation of multipotent retinal progenitors that were capable of differentiating into all major retinal cell types.
GSK3alpha, but not GSK3beta, is necessary in cardiomyocyte survival
Gsk3b regulates the maintenance of neural progenitors at the midbrain-hindbrain boundary in concert with E(Spl (显示 SGPL1 ELISA试剂盒)) factor activity.
A newly developed highly active GSK3beta inhibitor AR-534, reduced human TAU phosphorylation in TAU transgenic zebrafish.
lycogen synthase kinase-3 (GSK3) was identified as a substrate of protein kinase c delta (显示 PKCd ELISA试剂盒) in breast cancer cells.
Novel roles for Plk (显示 PLK1 ELISA试剂盒) and GSK3 regulation of ADAM13 (显示 ADAM33 ELISA试剂盒) function in cranial neural crest cell migration.
Interaction with Snail1 (显示 SNAI1 ELISA试剂盒)/2, and Twist function more generally, is regulated by GSK-3-beta-mediated phosphorylation of conserved sites in the WR domain.
These data suggest that the interactions of beta-catenin (显示 CTNNB1 ELISA试剂盒) with alpha-catenin (显示 CTNNA1 ELISA试剂盒) and GSK-3beta exert opposing effects on the terminal projections of ventral optic axons.
Our findings demonstrated that lovastatin restored LRRK2 (显示 LRRK2 ELISA试剂盒)-G2019S neurite degeneration by augmenting Akt (显示 AKT1 ELISA试剂盒)/NRF2 (显示 NFE2L2 ELISA试剂盒) pathway and inhibiting downstream GSK3b activity, which decreased phospho-tau levels. We suggested that lovastatin is a potential disease-modifying agent for LRRK2 (显示 LRRK2 ELISA试剂盒)-G2019S parkinsonism.
Mitochondrial function leads to extensive glycogen (显示 GYS1 ELISA试剂盒) accumulation late in oogenesis and is required for the developmental competence of the oocyte. Decreased insulin (显示 INS ELISA试剂盒) signaling initiates ETC remodeling and mitochondrial respiratory quiescence through glycogen synthase kinase 3 (显示 GSK3a ELISA试剂盒) (GSK3).
Drosophila-based findings highlight an apical role for Hyd (显示 UBR5 ELISA试剂盒) and Sgg in initiating Hedgehog (显示 SHH ELISA试剂盒) signalling, which could also be evolutionarily conserved in mammals
Results show that downregulation of GSK3 promotes synapse formation in Drosophila neurons. However in rats hippocampal neurons, GSK3 inhibition yields to decrease of synapses in young neurons culture and the opposite in aged culture.
upregulation of Nebula/DSCR1 is neuroprotective in the presence of APP upregulation and provides evidence for calcineurin inhibition as a novel target for therapeutic intervention in preventing axonal transport impairments associated with AD
The Par-1 (显示 F2R ELISA试剂盒)/GSK-3/Slimb pathway plays important roles in limiting the amount of pole plasm posteriorly and in degrading any mislocalized Oskar that results from leaky translational repression.
GSK-3 is required for biderectional axonal transport.
findings suggest a mechanism in which Shaggy/GSK-3beta activates calcineurin through Sarah phosphorylation on egg activation in Drosophila
roles for the kinases GSK3 and aPKC in cellular alignment, asymmetric protein distribution, and adhesion during the development of this polarized tissue
Insulin (显示 INS ELISA试剂盒) induces Myc (显示 MYC ELISA试剂盒) protein accumulation in Drosophila S2 cells, which correlates with a decrease in the activity of glycogen synthase kinase 3-beta (GSK3beta ) a kinase that is responsible for Myc (显示 MYC ELISA试剂盒) protein degradation.
The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, GSK3beta isoform
, glycogen synthase kinase-3 beta
, serine/threonine-protein kinase GSK3B
, factor A
, glycogen synthase kinase 3 beta variant 1
, glycogen synthase kinase 3 beta variant 2
, glycogen synthase kinase 3 beta variant 3
, glycogen synthase kinase 3 beta variant 4
, intracellular kinase
, CG2621 gene product from transcript CG2621-RA
, GSK-3 kinase
, Protein zeste-white 3
, Shaggy/Glycogen synthase kinase 3
, Shaggy/Zeste-white-3/Glycogen synthase kinase 3beta
, Zw3 kinase
, glycogen synthase Kinase-3
, glycogen synthase kinase 3
, glycogen synthase kinase 3Beta
, glycogen synthase kinase-3beta
, shaggy-zeste white 3
, shaggy/zeste-white 3
, zest-white 3
, zeste white 3
, zeste white-3
, zeste white3
, zeste-white 3