anti-FZD4 (FZD4) 抗体产品概述

Full name:
anti-Frizzled Family Receptor 4 抗体 (FZD4)
在www.antibodies-online.cn可供136 Frizzled Family Receptor 4 (FZD4) 抗体的23不同的供货商。 再加上,我们可以发FZD4 蛋白 (15)FZD4 试剂盒 (9)和数多这个蛋白质的别的产品。 总共173 FZD4产品已列进来了。
别名:
anon-WO0170980.10, anon-WO0170980.11, CD344, CG4626, Dfz4, Dmel\\CG4626, Dm Fz4, EVR1, FEVR, frizzled4, FZ-4, fz1, fz4, FZD4S, FzE4, GPCR, hFz4, zg01

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引用最多的anti-FZD4 抗体

  1. Human Polyclonal FZD4 Primary Antibody for EIA, WB - ABIN951305 : Ells, Guernsey, Wallace, Zheng, Vincer, Allen, Ingram, DaSilva, Siebert, Sheidow, Beis, Robitaille: Severe retinopathy of prematurity associated with FZD4 mutations. in Ophthalmic genetics 2010 (PubMed)
    Show all 5 references for 951305

  2. Cow (Bovine) Polyclonal FZD4 Primary Antibody for IHC, WB - ABIN2776715 : Dufourcq, Leroux, Ezan, Descamps, Lamazière, Costet, Basoni, Moreau, Deutsch, Couffinhal, Duplàa: Regulation of endothelial cell cytoskeletal reorganization by a secreted frizzled-related protein-1 and frizzled 4- and frizzled 7-dependent pathway: role in neovessel formation. in The American journal of pathology 2008 (PubMed)
    Show all 4 references for 2776715

  3. Human Monoclonal FZD4 Primary Antibody for FACS, ICC - ABIN4900303 : Baksh, Boland, Tuan: Cross-talk between Wnt signaling pathways in human mesenchymal stem cells leads to functional antagonism during osteogenic differentiation. in Journal of cellular biochemistry 2007 (PubMed)
    Show all 2 references for 4900303

  4. Human Polyclonal FZD4 Primary Antibody for ELISA, WB - ABIN408660 : You, Nguyen, Albers, Lin, Holcombe: Wnt pathway-related gene expression in inflammatory bowel disease. in Digestive diseases and sciences 2008 (PubMed)

  5. Human Monoclonal FZD4 Primary Antibody for FACS, ICC - ABIN4898976 : Despeaux, Chicanne, Rouer, De Toni-Costes, Bertrand, Mansat-De Mas, Vergnolle, Eaves, Payrastre, Girault, Racaud-Sultan: Focal adhesion kinase splice variants maintain primitive acute myeloid leukemia cells through altered Wnt signaling. in Stem cells (Dayton, Ohio) 2012 (PubMed)

更多抗FZD4的相互作用对抗体

Fruit Fly (Drosophila melanogaster) Frizzled Family Receptor 4 (FZD4) interaction partners

  1. Knockdown of Tc-fz1 alone interfered with the formation of the proximo-distal and the dorso-ventral axes during leg development, whereas no effect was observed with single Tc-fz2 (显示 FZD2 抗体) or Tc-fz4 RNAi knockdowns.

Human Frizzled Family Receptor 4 (FZD4) interaction partners

  1. Study shows that WNT5A (显示 WNT5A 抗体) stimulates dimerization of membrane-anchored FZD4 CRDs and oligomerization of full-length FZD4, which requires the integrity of CRD (显示 CRX 抗体) palmitoleoyl-binding residues. These results suggest that FZD receptors may form signalosomes in response to Wnt (显示 WNT2 抗体) binding through the CRDs and that the Wnt (显示 WNT2 抗体) palmitoleoyl group is important in promoting these interactions.

  2. FZD4 down-regulation leads to loss of WNT (显示 WNT2 抗体)/beta-catenin (显示 CTNNB1 抗体) signal activity and subsequently to reduced alveolar epithelial cell wound repair capacity and impaired expression of elastogenic components.

  3. his study showed that Let7b modulates the proliferation, invasiveness, and migration of liver cancer cell and reduces the proportion of cancer stem cells in liver cancer cell by inhibiting Wnt (显示 WNT2 抗体)/beta-catenin (显示 CTNNB1 抗体) signaling pathway via downregulated Frizzled4.

  4. Among the detected mutations, LRP5 (显示 LRP5 抗体) accounted for the largest proportion with a mean mutation rate of 16.1% (5/31, 16.1%), followed by NDP (显示 NDP 抗体) (3/31, 9.7%), FZD4 (2/31, 6.5%), TSPAN12 (显示 TSPAN12 抗体) (1/31, 3.2%), and KIF11 (显示 KIF11 抗体) (1/31, 3.2%). All the novel changes were predicted to be pathogenic by a series of bioinformatics analyses.

  5. human FZD4 assembles-in a DVL-independent manner-with Galpha12/13 but not representatives of other heterotrimeric G protein subfamilies.

  6. Several novel mutations (missense, non-stop (显示 USP22 抗体) and insertion) were detected in the coding regions of FZD4, TSPAN12 (显示 TSPAN12 抗体) and ZNF408 (显示 ZNF408 抗体) genes among the unrelated familial exudative vitreoretinopathy probands. The mutations in FZD4 and TSPAN12 (显示 TSPAN12 抗体) were involved in autosomal dominant and autosomal recessive families and further validates the involvement of these gene in exudative vitreoretinopathy development.

  7. Two were novel mutations: p.E134* and p.T503fs of FZD4 lead to the loss of FZD4 activity.

  8. Letter: FZD4+ and FZD4- melanocytes were significantly lower in hair follicles of patients with rhododenol-induced leukoderma.

  9. These structural, biophysical and cellular data, map Fz4 and putative Lrp5 (显示 LRP5 抗体)/6 binding sites to distinct patches on Norrin (显示 NDP 抗体), and reveal a GAG binding site spanning Norrin (显示 NDP 抗体) and Fz4 cysteine-rich domain.

  10. The relatively high prevalence of the p.[P33S(;)P168S] variant in ROP (显示 STXBP1 抗体) (retinopathy of prematurity) and intrauterine growth restriction suggests that it also may be a marker for increased risk of developing ROP (显示 STXBP1 抗体) and preterm birth.

Xenopus laevis Frizzled Family Receptor 4 (FZD4) interaction partners

  1. A splice variant of the Frizzled-4 receptor modulates Wnt (显示 WNT2 抗体) signalling in a dose-dependent, biphasic manner.

Mouse (Murine) Frizzled Family Receptor 4 (FZD4) interaction partners

  1. Fzd4 and Fzd6 (显示 FZD6 抗体) genes have a deep patterning effect on arterial vessel morphogenesis that may determine its functional efficiency

  2. Study identified a novel Wnt5a (显示 WNT5A 抗体)/Fzd4 signaling pathway that contributes to the regulation of dendrite morphogenesis

  3. These results question the conclusion that a dominant-negative mechanism would explain the dominance of the mutant L501fsX533 Fz4 allele in the transmission of a form of Familial exudative vitreoretinopathy.

  4. The data reveal both cell-autonomous and cell-nonautonomous effects, and they imply a central role for Norrin (显示 NDP 抗体)/Fz4 signaling in central nervous system vascular development and in the maintenance of the blood brain barrier/blood retina barrier state.

  5. Frizzled 4 regulates arterial network organization through noncanonical Wnt (显示 WNT2 抗体)/planar cell polarity signaling.

  6. Frizzled4 wnt (显示 WNT2 抗体) receptors are significantly increased in pathological neovascularization in a mouse model of oxygen-induced proliferative retinopathy.

  7. targeted inactivation of the TSK (显示 FBN1 抗体) gene in mice causes expansion of the ciliary body and up-regulation of Wnt2b (显示 WNT2B 抗体) and Fzd4 expression in the developing peripheral eye

  8. These results demonstrate that FZD4 is required for physiological and pathologic angiogenesis in the retina and for regulation of retinal endothelial cell differentiation.

  9. A major role for frizzled 4 and frizzled 8 (显示 FZD8 抗体) in controlling ureteric growth in the developing kidney.

  10. a Norrin (显示 NDP 抗体)-Fz4 signaling system plays a central role in vascular development in the eye and ear, and ligands unrelated to Wnts can act through Fz receptors

FZD4 抗原简介

Antigen Summary

This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence.

Alternative names and synonyms associated with FZD4

  • frizzled 4 (fz4) 抗体
  • frizzled homolog 4 (fzd4) 抗体
  • frizzled-4 (Tsp_10376) 抗体
  • frizzled family receptor 4 (FZD4) 抗体
  • frizzled family receptor 4 (Fzd4) 抗体
  • frizzled family receptor 4 (fzd4) 抗体
  • frizzled homolog 4 (Drosophila) (Fzd4) 抗体
  • anon-WO0170980.10 抗体
  • anon-WO0170980.11 抗体
  • CD344 抗体
  • CG4626 抗体
  • Dfz4 抗体
  • Dmel\\CG4626 抗体
  • Dm Fz4 抗体
  • EVR1 抗体
  • FEVR 抗体
  • frizzled4 抗体
  • FZ-4 抗体
  • fz1 抗体
  • fz4 抗体
  • FZD4S 抗体
  • FzE4 抗体
  • GPCR 抗体
  • hFz4 抗体
  • zg01 抗体

Protein level used designations for FZD4

CG4626-PA , CG4626-PB , fz4-PA , fz4-PB , frizzled homolog 1 , frizzled-4 , frizzled homolog 4 , WNT receptor frizzled-4 , frizzled 4, seven transmembrane spanning receptor , frizzled receptor 4 , fz-4 , rFz4 , frizzled 4 protein , xfz4 , cFz-4 , mFz4

GENE ID SPECIES
31659 Drosophila melanogaster
30363 Danio rerio
10902349 Trichinella spiralis
100231781 Taeniopygia guttata
8322 Homo sapiens
64558 Rattus norvegicus
399192 Xenopus laevis
373887 Gallus gallus
485149 Canis lupus familiaris
14366 Mus musculus
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