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抗Human FZD4 抗体:
抗Rat (Rattus) FZD4 抗体:
抗Mouse (Murine) FZD4 抗体:
Human Monoclonal FZD4 Primary Antibody for IHC (fro), FACS - ABIN2689205
Ells, Guernsey, Wallace, Zheng, Vincer, Allen, Ingram, DaSilva, Siebert, Sheidow, Beis, Robitaille: Severe retinopathy of prematurity associated with FZD4 mutations. in Ophthalmic genetics 2010
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Cow (Bovine) Polyclonal FZD4 Primary Antibody for IHC, WB - ABIN2776715
Dufourcq, Leroux, Ezan, Descamps, Lamazière, Costet, Basoni, Moreau, Deutsch, Couffinhal, Duplàa: Regulation of endothelial cell cytoskeletal reorganization by a secreted frizzled-related protein-1 and frizzled 4- and frizzled 7-dependent pathway: role in neovessel formation. in The American journal of pathology 2008
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Human Monoclonal FZD4 Primary Antibody for CyTOF, FACS - ABIN4900304
Baksh, Boland, Tuan: Cross-talk between Wnt signaling pathways in human mesenchymal stem cells leads to functional antagonism during osteogenic differentiation. in Journal of cellular biochemistry 2007
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Human Monoclonal FZD4 Primary Antibody for CyTOF, FACS - ABIN4900303
Chen, Park, Tang: Activity-dependent synaptic Wnt release regulates hippocampal long term potentiation. in The Journal of biological chemistry 2006
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Human Polyclonal FZD4 Primary Antibody for ELISA, WB - ABIN408660
You, Nguyen, Albers, Lin, Holcombe: Wnt pathway-related gene expression in inflammatory bowel disease. in Digestive diseases and sciences 2008
Human Monoclonal FZD4 Primary Antibody for FACS, ICC - ABIN4898976
Despeaux, Chicanne, Rouer, De Toni-Costes, Bertrand, Mansat-De Mas, Vergnolle, Eaves, Payrastre, Girault, Racaud-Sultan: Focal adhesion kinase splice variants maintain primitive acute myeloid leukemia cells through altered Wnt signaling. in Stem cells (Dayton, Ohio) 2012
Knockdown of Tc-fz1 alone interfered with the formation of the proximo-distal and the dorso-ventral axes during leg development, whereas no effect was observed with single Tc-fz2 (显示 FZD2 抗体) or Tc-fz4 RNAi knockdowns.
novel role of let-7b/Fzd4 axis through wnt (显示 WNT2 抗体) signaling
Study shows that WNT5A (显示 WNT5A 抗体) stimulates dimerization of membrane-anchored FZD4 CRDs and oligomerization of full-length FZD4, which requires the integrity of CRD (显示 CRX 抗体) palmitoleoyl-binding residues. These results suggest that FZD receptors may form signalosomes in response to Wnt (显示 WNT2 抗体) binding through the CRDs and that the Wnt (显示 WNT2 抗体) palmitoleoyl group is important in promoting these interactions.
FZD4 down-regulation leads to loss of WNT (显示 WNT2 抗体)/beta-catenin (显示 CTNNB1 抗体) signal activity and subsequently to reduced alveolar epithelial cell wound repair capacity and impaired expression of elastogenic components.
his study showed that Let7b modulates the proliferation, invasiveness, and migration of liver cancer cell and reduces the proportion of cancer stem cells in liver cancer cell by inhibiting Wnt (显示 WNT2 抗体)/beta-catenin (显示 CTNNB1 抗体) signaling pathway via downregulated Frizzled4.
Among the detected mutations, LRP5 (显示 LRP5 抗体) accounted for the largest proportion with a mean mutation rate of 16.1% (5/31, 16.1%), followed by NDP (显示 NDP 抗体) (3/31, 9.7%), FZD4 (2/31, 6.5%), TSPAN12 (显示 TSPAN12 抗体) (1/31, 3.2%), and KIF11 (显示 KIF11 抗体) (1/31, 3.2%). All the novel changes were predicted to be pathogenic by a series of bioinformatics analyses.
human FZD4 assembles-in a DVL-independent manner-with Galpha12/13 but not representatives of other heterotrimeric G protein subfamilies.
Several novel mutations (missense, non-stop (显示 USP22 抗体) and insertion) were detected in the coding regions of FZD4, TSPAN12 (显示 TSPAN12 抗体) and ZNF408 (显示 ZNF408 抗体) genes among the unrelated familial exudative vitreoretinopathy probands. The mutations in FZD4 and TSPAN12 (显示 TSPAN12 抗体) were involved in autosomal dominant and autosomal recessive families and further validates the involvement of these gene in exudative vitreoretinopathy development.
Two were novel mutations: p.E134* and p.T503fs of FZD4 lead to the loss of FZD4 activity.
Letter: FZD4+ and FZD4- melanocytes were significantly lower in hair follicles of patients with rhododenol-induced leukoderma.
These structural, biophysical and cellular data, map Fz4 and putative Lrp5 (显示 LRP5 抗体)/6 binding sites to distinct patches on Norrin (显示 NDP 抗体), and reveal a GAG binding site spanning Norrin (显示 NDP 抗体) and Fz4 cysteine-rich domain.
A splice variant of the Frizzled-4 receptor modulates Wnt (显示 WNT2 抗体) signalling in a dose-dependent, biphasic manner.
These data expose a stromal component that regulates the earliest stages of tumorigenesis in the cerebellum, and a novel role for the Norrin (显示 NDP 抗体)/Fzd4 axis as an endogenous anti-tumor signal in the preneoplastic niche.
Fzd4 and Fzd6 (显示 FZD6 抗体) genes have a deep patterning effect on arterial vessel morphogenesis that may determine its functional efficiency
Study identified a novel Wnt5a (显示 WNT5A 抗体)/Fzd4 signaling pathway that contributes to the regulation of dendrite morphogenesis
These results question the conclusion that a dominant-negative mechanism would explain the dominance of the mutant L501fsX533 Fz4 allele in the transmission of a form of Familial exudative vitreoretinopathy.
The data reveal both cell-autonomous and cell-nonautonomous effects, and they imply a central role for Norrin (显示 NDP 抗体)/Fz4 signaling in central nervous system vascular development and in the maintenance of the blood brain barrier/blood retina barrier state.
Frizzled 4 regulates arterial network organization through noncanonical Wnt (显示 WNT2 抗体)/planar cell polarity signaling.
Frizzled4 wnt (显示 WNT2 抗体) receptors are significantly increased in pathological neovascularization in a mouse model of oxygen-induced proliferative retinopathy.
targeted inactivation of the TSK (显示 FBN1 抗体) gene in mice causes expansion of the ciliary body and up-regulation of Wnt2b (显示 WNT2B 抗体) and Fzd4 expression in the developing peripheral eye
These results demonstrate that FZD4 is required for physiological and pathologic angiogenesis in the retina and for regulation of retinal endothelial cell differentiation.
A major role for frizzled 4 and frizzled 8 (显示 FZD8 抗体) in controlling ureteric growth in the developing kidney.
This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence.
, frizzled homolog 1
, frizzled homolog 4
, WNT receptor frizzled-4
, frizzled 4, seven transmembrane spanning receptor
, frizzled receptor 4
, frizzled 4 protein