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抗Mouse (Murine) DKK4 抗体:
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抗Rat (Rattus) DKK4 抗体:
Human Polyclonal DKK4 Primary Antibody for EIA, WB - ABIN951912
Matsui, Yamaguchi, Maekawa, Miyazaki, Takano, Uetake, Inoue, Otaka, Otsuka, Sato, Yamashita, Takahashi, Enomoto: DICKKOPF-4 and -2 genes are upregulated in human colorectal cancer. in Cancer science 2009
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Human Polyclonal DKK4 Primary Antibody for IHC (p), WB - ABIN388357
Hirata, Hinoda, Majid, Chen, Zaman, Ueno, Nakajima, Tabatabai, Ishii, Dahiya: DICKKOPF-4 activates the noncanonical c-Jun-NH2 kinase signaling pathway while inhibiting the Wnt-canonical pathway in human renal cell carcinoma. in Cancer 2011
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Human Polyclonal DKK4 Primary Antibody for EIA, IHC (p) - ABIN357074
Krupnik, Sharp, Jiang, Robison, Chickering, Amaravadi, Brown, Guyot, Mays, Leiby, Chang, Duong, Goodearl, Gearing, Sokol, McCarthy: Functional and structural diversity of the human Dickkopf gene family. in Gene 1999
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Human Polyclonal DKK4 Primary Antibody for EIA, IHC (p) - ABIN357073
Yoshida, Satoh, Mitsuya, Tate: Assignment of the human dickkopf (Xenopus) homolog 4 (DKK4) to chromosome 8p11.2-->p11.1 by fluorescence in situ hybridization. in Cytogenetics and cell genetics 2001
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sweat gland development shows a relay of regulatory steps initiated by Wnt (显示 WNT2 抗体)/beta-catenin (显示 CTNNB1 抗体) - itself modulated by Dkk4 - with subsequent participation of Eda (显示 EDA 抗体) and Shh (显示 SHH 抗体) pathways.
These results showed that Dkk4 functions as an inhibitor of osteoblastogenesis through Wnt (显示 WNT2 抗体)/beta-catenin (显示 CTNNB1 抗体) signaling, providing new insights into the relationship between Wnt (显示 WNT2 抗体)/beta-catenin (显示 CTNNB1 抗体) signaling and Dkk4 in bone formation.
It would appear that deregulation of the WNT (显示 WNT2 抗体) pathway by overexpression of DKK4 may further impair WNT (显示 WNT2 抗体) signaling and lead to Anorectal malformations.
Dkk4 affects an auxiliary pathway for Eda (显示 EDA 抗体)-independent development of secondary hair
Dkk4 acts in a negative feedback loop to attenuate canonical Wnt (显示 WNT2 抗体) signaling and may facilitate a switch to the non-canonical Wnt (显示 WNT2 抗体) planar cell polarity pathway that is involved in cell movements during morphogenesis.
Microarray profiling of genes differentially regulated by short exposure to recombinant Eda-A1 (显示 EDA 抗体) in embryonic eda (显示 EDA 抗体)(-/-) skin explants, was performed to identify direct targets of ectodysplasin pathway.
We found that TCF7L1 (显示 TCF3 抗体) recruits the C-terminal binding protein (CtBP (显示 CTBP2 抗体)) and histone deacetylase 1 (HDAC1 (显示 HDAC1 抗体)) to the DKK4 promoter to repress DKK4 gene expression. In the absence of TCF7L1 (显示 TCF3 抗体), TCF7L2 (显示 TCF7L2 抗体) and beta-catenin (显示 CTNNB1 抗体) occupancy at the DKK4 promoter is stimulated and DKK4 expression is increased. These findings uncover a critical role for TCF7L1 (显示 TCF3 抗体) in repressing DKK4 gene expression to promote the oncogenic potential of CRCs.
DKK4 expression is significantly upregulated in human masticatory mucosa during wound healing
DKK4 may have function on the development and progression of pancreatic cancer.
The recurrence of benign tumors of mammary gland occurred predominantly in women-carriers of mutant alleles with polymorphism rs8190924 of gene GSR (显示 GSR 抗体) and AA rs3763511of gene DKK4.
DKK4 upregulated by T3/TR antagonizes the Wnt (显示 WNT2 抗体) signal pathway to suppress tumor cell progression
rs3923086 in AXIN2 (显示 AXIN2 抗体) and rs3763511 in DKK4 that did not show any association in the overall population were significantly associated with early on-set and estrogen receptor (显示 ESR1 抗体) negative breast cancers, respectively.
Our findings suggest a potential tumour suppressive role of DKK4 as well as that of an important regulator of HCC (显示 FAM126A 抗体).
Found the unique expression of the Wnt (显示 WNT2 抗体) antagonist DKK4 in SW480APC, but not parental SW480 cell-derived exosomes. Upregulation of DKK4 in SW480APC cells was confirmed by RT-PCR, immunoblotting, and immunogold electron microscopy.
The TR/DKK4/Wnt (显示 WNT2 抗体)/beta-catenin (显示 CTNNB1 抗体) cascade influences the proliferation and migration of hepatoma cells during the metastasis process and support a tumor suppressor role of the thyroid hormone receptor (显示 THRA 抗体).
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. Activity of this protein is modulated by binding to the Wnt co-receptor and the co-factor kremen 2.
dickkopf homolog 4
, dickkopf-related protein 4