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Human S100A9 Protein expressed in Wheat germ - ABIN1319076
Venkataraman, Cole, Svoboda, Pohl, Cole: Cationic polypeptides are required for anti-HIV-1 activity of human vaginal fluid. in Journal of immunology (Baltimore, Md. : 1950) 2005
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Human S100A9 Protein expressed in HEK-293 Cells - ABIN2731328
Yeap, Wong, Shimasaki, Teo, Quek, Yong, Diong, Bertoletti, Linn, Wong: CD16 is indispensable for antibody-dependent cellular cytotoxicity by human monocytes. in Scientific reports 2016
Data suggest that fecal calprotectin (显示 S100A8 蛋白) may be a potential biomarker to identify patients with ankylosing spondylitis (AS) at risk of developing inflammatory bowel disease (IBD).
S100A9 induces anti-apoptotic effect on normal and allergic neutrophils by increasing cytokine secretion of monocytes
S100A9, a protein previously described to be involved in modulation of inflammatory response, was found to interact with schistosoma MEG (显示 PTPN4 蛋白)-14.
Elevated S100A8 (显示 S100A8 蛋白) and S100A9 gene expression in SP-infected HMEECs and in the middle ear mucosa of OM, minor co-localized with neutrophil markers suggests that middle ear epithelial cell secretion of S100A8 (显示 S100A8 蛋白) and S100A9 may play a role in the pathogenesis of recurrent and chronic OM
The findings show that reduced PTP1B (显示 PTPN1 蛋白) responses contribute to disease symptoms in part by enhancing S100A9 expression during viral-associated chronic obstructive pulmonary disease exacerbations.
results of this study support an additional role of calprotectin (显示 S100A8 蛋白) in assessing inflammatory activity in patients with RA
High calprotectin (显示 S100A8 蛋白) activity could be demonstrated within the lumen of vermiform appendix specimens following appendectomy for acute appendicitis.
observations indicate a novel way in which S100A9 may contribute to the pathogenesis of gout, by priming neutrophils to respond to MSUs.
S100A9 was an ATRA-responsive gene, and PML (显示 PML 蛋白)/RARalpha (显示 RARA 蛋白) was necessary for the ATRA-induced expression of S100A9 in acute promyelocytic leukemia (显示 PML 蛋白) (APL (显示 FASL 蛋白)) cells. PML (显示 PML 蛋白)/RARalpha (显示 RARA 蛋白) and PU.1 were necessary for the ATRA-induced expression of S100A9 in APL (显示 FASL 蛋白) cells. Furthermore, S100A9 promoted apoptosis in APL (显示 FASL 蛋白) cells and affected cell growth.
Salivary S100A9 is a biomarker for oral squamous cell carcinoma in a Hungarian population.
this study shows that S100A9 inhibits B lymphopoiesis by acting on myeloid cells and promoting the release of inflammatory molecules, including IL-1beta (显示 IL1B 蛋白)
Study verified porcine calprotectin (S100A8 (显示 S100A8 蛋白)/A9) expression at the protein level in multiple Haemophilus parasuis infected tissues and explored their molecular characterization.
Data suggest that up-regulation of S100A8 (显示 S100A8 蛋白) and S100A9 is a key component of early endometrial response to uterine involution in the post-partum period and to prevent chronic endometritis/uterine inflammation; up-regulation can be influenced by diet.
Neutrophil-derived S100A8 (显示 S100A8 蛋白)/A9 promotes thrombocytosis in diabetic mice
S100A9 knockdown almost completely abrogated the effects of IRF7 (显示 IRF7 蛋白) deletion on granulocytic myeloid-derived suppressor cells development and tumor metastasis.
Perinatal alarmins S100A8 (显示 S100A8 蛋白) and S100A9 specifically altered MyD88 (显示 MYD88 蛋白)-dependent proinflammatory gene programs. S100 programming prevented hyperinflammatory responses without impairing pathogen defense. TRIF (显示 RNF138 蛋白)-adaptor-dependent regulatory genes remained unaffected by perinatal S100 programming and responded strongly to lipopolysaccharide, but were barely expressed.
vitro studies on the mechanisms/pathways involved in leukemic cell differentiation revealed that binding of S100A9 to Toll-like receptor 4 (TLR4 (显示 TLR4 蛋白)) promotes activation of p38 mitogen-activated protein kinase (显示 MAPK14 蛋白), extracellular signal-regulated kinases 1 and 2, and Jun N-terminal kinase (显示 MAPK8 蛋白) signaling pathways, leading to myelomonocytic and monocytic AML (显示 RUNX1 蛋白) cell differentiation.
these results indicate that CD14 (显示 CD14 蛋白) is a co-receptor of TLR4 (显示 TLR4 蛋白) in the S100A9-induced cytokine response.
Mechanistic studies showed that in MDSCs, ATF3 (显示 ATF3 蛋白) was transrepressed by the GC receptor GR through direct binding to the negative GR-response element. S100A9 is the major transcriptional target of ATF3 (显示 ATF3 蛋白) in Granulocytic Myeloid-derived Suppressor Cells.
CHI3L1 (显示 CHI3L1 蛋白)-mediated cell proliferation/survival involves partial downregulation of the pro-apoptotic S100A9 protein that is highly expressed during the acute phase of colitis, by binding to the S100A9 receptor, RAGE (显示 AGER 蛋白) (Receptor for Advanced Glycation End products).
Although MRP-8 (显示 S100A8 蛋白)/-14 expression is highly increased in experimental, these proteins do not contribute to the pathogenesis in the effector phase of epidermolysis bullosa acquisita and bullous pemphigoid (显示 DST 蛋白).
Rps14 (显示 RPS14 蛋白) haploinsufficiency in del(5q) myelodysplastic syndrome is linked to activation of the innate immune system and induction of S100A8 (显示 S100A8 蛋白)-S100A9 expression, leading to a p53 (显示 TP53 蛋白)-dependent erythroid differentiation defect.
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and altered expression of this protein is associated with the disease cystic fibrosis.
, S100 calcium-binding protein A9 (calgranulin B)
, calgranulin B
, calprotectin L1H subunit
, leukocyte L1 complex heavy chain
, migration inhibitory factor-related protein 14
, protein S100-A9
, S100 calcium binding protein A9 (calgranulin B)
, intracellular calcium-binding protein (MRP14)
, myeloid-related protein 14
, protein MRP-126
, S100 calcium binding protein A9
, S100 calcium-binding protein A9
, neutrophil cytosolic 23 kDa protein
, RNA-binding region containing protein 2-like