HFE2 (HFE2) ELISA试剂盒产品概述

Full name:
Hemochromatosis Type 2 (Juvenile) ELISA试剂盒 (HFE2)
在www.antibodies-online.cn可供64 Hemochromatosis Type 2 (Juvenile) (HFE2) ELISA试剂盒的13不同的供货商。 再加上,我们可以发HFE2 抗体 (100)HFE2 蛋白 (14)和数多这个蛋白质的别的产品。 总共186 HFE2产品已列进来了。
别名:
2310035L15Rik, 5230400G09Rik, AI414844, AI789733, DKFZp468F2322, DL-M, hemojuvelin, HFE2, HFE2A, HJV, JH, Rgmc

引用最多的HFE2 ELISA试剂盒

  1. Human HFE2 ELISA Kit for Sandwich ELISA - ABIN415112 : Rumjon, Sarafidis, Brincat, Musto, Malyszko, Bansal, Macdougall: Serum hemojuvelin and hepcidin levels in chronic kidney disease. in American journal of nephrology 2012 (PubMed)
    Show all 10 references for 415112

  2. Mouse (Murine) HFE2 ELISA Kit for Sandwich ELISA - ABIN415800 : Krijt, Frýdlová, Kukačková, Fujikura, Přikryl, Vokurka, Nečas: Effect of iron overload and iron deficiency on liver hemojuvelin protein. in PLoS ONE 2012 (PubMed)
    Show all 2 references for 415800

适于 HFE2 相互作用对的更多 ELISA 试剂盒

Human Hemochromatosis Type 2 (Juvenile) (HFE2) interaction partners

  1. A novel homozygous mutation in HJV gene identified in an Arab patient with juvenile hemochromatosis (显示 HFE ELISA试剂盒) and hepatocellular carcinoma.

  2. study shows that patients with CRA had high expression of BMP6 (显示 BMP6 ELISA试剂盒) and hepcidin (显示 HAMP ELISA试剂盒) and low expression of s-HJV. BMP6 (显示 BMP6 ELISA试剂盒) was found to be negatively correlated with s-HJV; both regulate hepcidin (显示 HAMP ELISA试剂盒) expression and play important roles in the development of anemia.

  3. HJV levels are low in NAFLD (显示 TSC2 ELISA试剂盒) and even lower in iron overloaded NAFLD (显示 TSC2 ELISA试剂盒).

  4. Data show that transmembrane serine protease (显示 F2 ELISA试剂盒) TMPRSS6 (显示 TMPRSS6 ELISA试剂盒) cleaves both the heterodimeric and the full-length mutant hemojuvelin (m-HJV).

  5. Hereditary haemochromatosis caused by homozygous HJV mutation evolved through paternal disomy.

  6. The study demonstrates that the two upstream open reading frames (with 28 and 19 codons) present in the 5' UTR (显示 UTS2R ELISA试剂盒) of the human HJV mRNA have the ability to significantly decrease translational efficiency under normal conditions.

  7. Case Reports: juvenile hemochromatosis (显示 HFE ELISA试剂盒) associated with simple heterozygosity for novel HJV mutations and unknown genetic factors.

  8. suggesting that the homozygous mutation p.C321X in HJV is causative in the patient with hemochromatosis (显示 HFE ELISA试剂盒)

  9. In dialysis patients, hemojuvelin levels are significantly increased but obesity does not have an additional impact.

  10. Membrane bound hemojuvelin (HJV) is associated with decreasing total kidney iron, secreting hepcidin (显示 HAMP ELISA试剂盒), and promoting the degradation of ferroportin (显示 SLC40A1 ELISA试剂盒) during acute kidney injury, whereas soluble HJV does the opposite.

Mouse (Murine) Hemochromatosis Type 2 (Juvenile) (HFE2) interaction partners

  1. Hjv (--) and Hfe (显示 HFE ELISA试剂盒) (C282YC282Y) transgenic mice displayed enhanced colonization of deep tissues by Yersinia pseudotuberculosis following oral inoculation, recapitulating enhanced susceptibility of humans with hemochromatosis (显示 HFE ELISA试剂盒) to disseminated infection with enteropathogenic Yersinia.

  2. The data demonstrate that endothelial cells are the predominant source of BMP6 (显示 BMP6 ELISA试剂盒) in the liver and support a model in which endothelial cells BMP6 (显示 BMP6 ELISA试剂盒) has paracrine actions on hepatocyte hemojuvelin to regulate hepcidin (显示 HAMP ELISA试剂盒) transcription and maintain systemic iron homeostasis.

  3. The minor variant of the HJV polymorphic site rs16827043 is a significant factor associated with hypertension among 50 year-old individuals compared with the AA genotype carriers. For the other polymorphic variant rs7536827, association with hypertension was found only among normal or slightly overweight A-allele carriers. In conclusion, HJV genetic variants were associated with essential hypertension in Finnish subjects.

  4. Results indicate that an efficient induction of hepcidin (显示 HAMP ELISA试剂盒) expression by hemojuvelin (HJV) requires its interaction with neogenin (显示 NEO1 ELISA试剂盒).

  5. Single Hjv(-)/(-) and double Hfe (显示 HFE ELISA试剂盒)(-)/(-)Hjv(-)/(-) mice exhibit comparable iron overload. Hfe (显示 HFE ELISA试剂盒) and Hjv regulate hepcidin (显示 HAMP ELISA试剂盒) via the same pathway.

  6. Results show that HFE (显示 HFE ELISA试剂盒) may depend on HJV for hepcidin (显示 HAMP ELISA试剂盒) regulation. Residual hepcidin (显示 HAMP ELISA试剂盒) in the absence of HFE (显示 HFE ELISA试剂盒) suggests either the presence of an unknown regulator synergistic with HJV or that HJV is sufficient to maintain basal levels of hepcidin (显示 HAMP ELISA试剂盒).

  7. Parenchymal hepatic iron overload does not suffice to trigger progression of liver steatosis to steatohepatitis or fibrosis in Hjv knockout C57BL/6 mice.

  8. Hjv is not required for sensing of body iron levels and merely functions as an enhancer for iron signaling to hepcidin (显示 HAMP ELISA试剂盒).

  9. Deletion of Hjv in mice leads to abnormal retinal angiogenesis/vasculogenesis, with proliferation of new, leaky blood vessels in the vitreous.

  10. Loss of matriptase-2 (显示 TMPRSS6 ELISA试剂盒) increases bone morphogenetic protein-dependent signaling, while paradoxically decreasing liver hemojuvelin protein content.

HFE2 抗原简介

Antigen Summary

The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.

Alternative names and synonyms associated with HFE2

  • hemochromatosis type 2 (juvenile) (HFE2) Elisa Kit
  • hemochromatosis type 2 (juvenile) (Hfe2) Elisa Kit
  • hemochromatosis type 2 (juvenile) (human homolog) (Hfe2) Elisa Kit
  • hemojuvelin (LOC100355707) Elisa Kit
  • 2310035L15Rik Elisa Kit
  • 5230400G09Rik Elisa Kit
  • AI414844 Elisa Kit
  • AI789733 Elisa Kit
  • DKFZp468F2322 Elisa Kit
  • DL-M Elisa Kit
  • hemojuvelin Elisa Kit
  • HFE2 Elisa Kit
  • HFE2A Elisa Kit
  • HJV Elisa Kit
  • JH Elisa Kit
  • Rgmc Elisa Kit

Protein level used designations for HFE2

hemochromatosis type 2 (juvenile) , RGM domain family member C , haemojuvelin , hemochromatosis type 2 protein , hemojuvelin , repulsive guidance molecule c , hemochromatosis type 2 (juvenile) (human homolog) , hemochromatosis type 2 protein homolog , repulsive guidance molecule C

GENE ID SPECIES
475830 Canis lupus familiaris
698805 Macaca mulatta
743630 Pan troglodytes
746490 Pan troglodytes
100174250 Pongo abelii
100594831 Nomascus leucogenys
148738 Homo sapiens
310681 Rattus norvegicus
100733082 Cavia porcellus
100155778 Sus scrofa
100335368 Bos taurus
101114997 Ovis aries
69585 Mus musculus
100355707 Oryctolagus cuniculus
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