HFE (HFE) ELISA试剂盒产品概述

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Hemochromatosis ELISA试剂盒 (HFE)
在www.antibodies-online.cn可供1 Hemochromatosis (HFE) ELISA试剂盒的1不同的供货商。 再加上,我们可以发HFE 抗体 (78)HFE 蛋白 (15)和数多这个蛋白质的别的产品。 总共101 HFE产品已列进来了。
别名:
HFE1, HH, HLA-H, MR2, MVCD7, TFQTL2
list all ELISA KIts 基因 基因ID UniProt
HFE 3077 Q30201
大鼠 HFE HFE 29199 O35799
小鼠 HFE HFE 15216 P70387

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HFE (HFE) ELISA试剂盒 by Reactivity

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适于 HFE 相互作用对的更多 ELISA 试剂盒

Human Hemochromatosis (HFE) interaction partners

  1. No significant differences in frequencies of the alleles with mutations in coding regions of the HFE gene (C282Y, H63D, and S65C) were detected between the analyzed patients (with stomach cancer, metabolic syndrome, fatty liver disease, or type 2 diabetes mellitus) and the control Caucasoid sample

  2. these findings support a larger scale screening for HERPUD1 (显示 HERPUD1 ELISA试剂盒) R50H and HFE H63D variants in the sub-group of 1ATD patients developing significant chronic hepatic injuries (hepatomegaly, chronic cholestasis, elevated liver enzymes) and at risk developing liver cirrhosis.

  3. There was a time-dependent improvement in the interpretation of the clinical significance of HFE genotypes. HFE molecular genetic testing, performed by non-US Food and Drug Administration-approved laboratory-developed tests, demonstrated excellent accuracy, sensitivity, and specificity. Clinical interpretations were more heterogeneous, probably owing to the low clinical penetrance of some common HFE genotypes

  4. comparison between the 2 methods by Fleiss' kappa analysis showed that 5' nuclease (显示 DCLRE1C ELISA试剂盒) assay identified the H63D and S65C haplotype as well as the reference method in all 153 tested samples. Our results showed that novel method probe-based real-time PCR were capable to detect 2 adjacent polymorphisms without errors in genotyping

  5. We discuss herein the puzzling distribution of the two major hemochromatosis HFE mutations associated with hereditary hemochromatosis. Thus, one can observe a low frequency of C282Y and, in contrast, one of the highest European frequencies of H63D in the Basque population.

  6. The results show an association between presence of one or both H63D alleles and development of BIP (显示 GDF10 ELISA试剂盒) in testicular cancer patients treated with bleomycin combination chemotherapy.

  7. C282Y but not H63D mutation of HFE was related to elevated cancer risk.

  8. Rare HFE variants are therefore the most frequent cause of hemochromatosis in non-C282Y homozygote HFE patients

  9. in Greek population cohort the frequencies of polymorphism were as follows: rs1800562: GG (wildtype)=97.0%, GA=1.5%,AA=1.5%; rs1799945: CC (wildtype)=74.4%, CG=23.4%, GG=2.2%; rs1800730:AA (wildtype)=98.1%, AT=1.5% and TT=0.4%. No association between the HFE polymorphisms rs1800562, rs1799945 and rs1800730 and gender could be established.

  10. In conclusion, our metaanalysis showed a marginal higher prevalence of H63D variant of the HFE gene in alcoholic liver disease but did not support an increased risk of C282Y mutation.

Mouse (Murine) Hemochromatosis (HFE) interaction partners

  1. the aging HFE KO mouse on an SV129 genetic background has the potential to facilitate the investigation of cardiomyopathy induced by HFE gene mutations.

  2. unlike homozygous Hfe deletion, heterozygous gene deletion disrupted glucose homeostasis but did not affect lipid metabolism or liver injury.

  3. Single Hjv (显示 HFE2 ELISA试剂盒)(-)/(-) and double Hfe(-)/(-)Hjv (显示 HFE2 ELISA试剂盒)(-)/(-) mice exhibit comparable iron overload. Hfe and Hjv (显示 HFE2 ELISA试剂盒) regulate hepcidin (显示 HAMP ELISA试剂盒) via the same pathway.

  4. Results show that HFE requires HJV (显示 HFE2 ELISA试剂盒) to activate downstream signal transduction pathways for hepcidin (显示 HAMP ELISA试剂盒) regulation.

  5. Alterations in cholesterol metabolism associated with expression of H63D-HFE may contribute to the development of AD.

  6. results provide evidence that HFE induces hepcidin (显示 HAMP ELISA试剂盒) expression via the BMP pathway: HFE interacts with ALK3 (显示 BMPR1A ELISA试剂盒) to stabilize ALK3 (显示 BMPR1A ELISA试剂盒) protein and increase ALK3 (显示 BMPR1A ELISA试剂盒) expression at the cell surface.

  7. These results support in vivo studies which suggest that Hfe and Tfr2 (显示 TFR2 ELISA试剂盒) can independently regulate hepcidin (显示 HAMP ELISA试剂盒).

  8. A mutation in the HFE gene is associated with altered brain iron profiles and increased oxidative stress in mice.

  9. Hfe-knockout mice did not have higher brain iron levels than wildtype controls.

  10. Hfe(-/-) retinal pigment epithelial cells exhibited slower senescence rate and higher survivin (显示 BIRC5 ELISA试剂盒) expression than wild type cells. Hfe(-/-) cells migrated faster and showed greater glucose uptake and increased expression of GLUTs.

HFE 抗原简介

Antigen Summary

The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene. At least nine alternatively spliced variants have been described for this gene. Additional variants have been found but their full-length nature has not been determined.

Alternative names and synonyms associated with HFE

  • hemochromatosis (HFE) Elisa Kit
  • hemochromatosis (Hfe) Elisa Kit
  • HFE1 Elisa Kit
  • HH Elisa Kit
  • HLA-H Elisa Kit
  • MR2 Elisa Kit
  • MVCD7 Elisa Kit
  • TFQTL2 Elisa Kit

Protein level used designations for Hemochromatosis (HFE) ELISA试剂盒

MHC class I-like protein HFE , hereditary hemochromatosis protein , hereditary hemochromatosis protein HLA-H , high Fe , RT1-CAFE , hereditary hemochromatosis protein homolog , hemochromatosis protein

GENE ID SPECIES
3077 Homo sapiens
497622 Bos taurus
29199 Rattus norvegicus
15216 Mus musculus
462489 Pan troglodytes
100688951 Canis lupus familiaris
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