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In cisplatin resistant cells, shRNA mediated inhibition of V-ATPase (显示 ATP6V1H 蛋白)-V0a2 enhanced sensitivity towards both cisplatin and carboplatin.
a2V deficiency disrupts the endolysosomal route in Notch (显示 NOTCH1 蛋白) and TGF signaling, thereby impairing mammary gland development.
Senescence-associated impaired expression of ATP6V0A2 triggers changes in Golgi structure and glycosylation in old fibroblasts, which demonstrates a role of ATP6V0A2 in cellular senescence program.
the results from this study demonstrate that the a2-subunit isoform of Vacuolar ATPase regulates Notch (显示 NOTCH1 蛋白) signaling in breast tumor cells
Case Report: novel ATP6V0A2 mutations in an infant with cutis laxa.
Expression of a2 vacuolar ATPase in spermatozoa is associated with semen quality and chemokine (显示 CCL1 蛋白)-cytokine profiles in infertile men.
Mutations in the ATP6V0A2 gene is associated with autosomal recessive cutis laxa.
Data show that the V-ATPase a2-subunit might actually be embedded into and/or closely associated with membrane phospholipids even in the absence of any obvious predicted transmembrane segments.
Specific motifs of the V-ATPase a2-subunit isoform interact with catalytic and regulatory domains of ARNO (显示 CYTH2 蛋白).
Studies indicate that mutations in the ATP6V0A2 gene were found in families with autosomal recessive cutis laxa.
Report Atp6v0a2 up-regulation/inflammatory response during preimplantation period of pregnancy may lead to successful pregnancy outcome.
Deceased expression of Atp6v0a2 in the various immune cell populations of the spleen and blood suggests that the maternal environment is not supportive to fetus and leads to poor pregnancy outcome in the abortion-prone mating model
a2V regulates the delicate cytokine and chemokine (显示 CCL1 蛋白) networks that coordinate the recruitment of macrophages for successful placental development and growth at the feto-maternal interface.
These results suggest that ISF/ShIF confers stromal cells with enhanced supporting activities for HSCs by modulating Wnt (显示 WNT2 蛋白)-activity and the extracellular matrix.
Data demonstrate the crucial role of early endosomal acidification and V-ATPase (显示 ATP6V1H 蛋白)/ARNO (显示 CYTH2 蛋白)/Arf6 (显示 ARF6 蛋白) interactions in the regulation of the endocytic degradative pathway.
The protein encoded by this gene is a subunit of the vacuolar ATPase (v-ATPase), an heteromultimeric enzyme that is present in intracellular vesicles and in the plasma membrane of specialized cells, and which is essential for the acidification of diverse cellular components. V-ATPase is comprised of a membrane peripheral V(1) domain for ATP hydrolysis, and an integral membrane V(0) domain for proton translocation. The subunit encoded by this gene is a component of the V(0) domain. Mutations in this gene are a cause of both cutis laxa type II and wrinkly skin syndrome.
ATPase, H+ transporting, lysosomal V0 subunit a
, V-type proton ATPase 116 kDa subunit a
, V-type proton ATPase 116 kDa subunit a isoform 2
, vacuolar H(+)-transporting ATPase 116 kDa subunit, a2 isoform
, lysosomal H(+)-transporting ATPase V0 subunit a2
, regeneration and tolerance factor
, v-ATPase 116 kDa
, v-type proton ATPase 116 kDa subunit a
, vacuolar proton translocating ATPase 116 kDa subunit a
, V-ATPase 116 kDa
, vacuolar proton translocating ATPase 116-kDa subunit a2
, ATPase, H+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 2 (38kD)
, T-cell expressing clone j6
, immune suppressor factor J6B7
, ATPase, H+ transporting, lysosomal V0 subunit a2