ATP6V0A2 蛋白 (ATP6V0A2)产品概述

Full name:
ATPase, H+ Transporting, Lysosomal V0 Subunit A2 蛋白 (ATP6V0A2)
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别名:
8430408C20Rik, A2, AI385560, ARCL, ARCL2A, ATP6a2, Atp6n1d, Atp6n2, atp6v0a2, AW489264, C76904, Cc1-3, ISF, J6b7, RTF, SHIF, si:ch211-199i18.4, Stv1, Tj6, TJ6M, TJ6s, V-ATPase 116 kDa, V-ATPase a2, VPH1, WSS
列出全部蛋白 基因 基因ID UniProt
ATP6V0A2 23545 Q9Y487
小鼠 ATP6V0A2 ATP6V0A2 21871 P15920
大鼠 ATP6V0A2 ATP6V0A2 116455  

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Human ATPase, H+ Transporting, Lysosomal V0 Subunit A2 (ATP6V0A2) interaction partners

  1. a2V deficiency disrupts the endolysosomal route in Notch (显示 NOTCH1 蛋白) and TGF signaling, thereby impairing mammary gland development.

  2. Senescence-associated impaired expression of ATP6V0A2 triggers changes in Golgi structure and glycosylation in old fibroblasts, which demonstrates a role of ATP6V0A2 in cellular senescence program.

  3. the results from this study demonstrate that the a2-subunit isoform of Vacuolar ATPase regulates Notch (显示 NOTCH1 蛋白) signaling in breast tumor cells

  4. Case Report: novel ATP6V0A2 mutations in an infant with cutis laxa.

  5. Expression of a2 vacuolar ATPase in spermatozoa is associated with semen quality and chemokine (显示 CCL1 蛋白)-cytokine profiles in infertile men.

  6. Mutations in the ATP6V0A2 gene is associated with autosomal recessive cutis laxa.

  7. Data show that the V-ATPase a2-subunit might actually be embedded into and/or closely associated with membrane phospholipids even in the absence of any obvious predicted transmembrane segments.

  8. Specific motifs of the V-ATPase a2-subunit isoform interact with catalytic and regulatory domains of ARNO (显示 CYTH2 蛋白).

  9. Studies indicate that mutations in the ATP6V0A2 gene were found in families with autosomal recessive cutis laxa.

  10. RTF (Regeneration and tolerance factor), the alpha-2 isoform of the alpha subunit (显示 POLG 蛋白) of vacuolar ATPase, has a role in controlling IL-1 beta (显示 IL1B 蛋白) secretion by regulating P2X7 (显示 P2RX7 蛋白) activity.

Mouse (Murine) ATPase, H+ Transporting, Lysosomal V0 Subunit A2 (ATP6V0A2) interaction partners

  1. a2V deficiency disrupts the endolysosomal route in Notch (显示 NOTCH1 蛋白) and TGF signaling, thereby impairing mammary gland development.

  2. Report Atp6v0a2 up-regulation/inflammatory response during preimplantation period of pregnancy may lead to successful pregnancy outcome.

  3. Deceased expression of Atp6v0a2 in the various immune cell populations of the spleen and blood suggests that the maternal environment is not supportive to fetus and leads to poor pregnancy outcome in the abortion-prone mating model

  4. a2V regulates the delicate cytokine and chemokine (显示 CCL1 蛋白) networks that coordinate the recruitment of macrophages for successful placental development and growth at the feto-maternal interface.

  5. Specific motifs of the V-ATPase a2-subunit isoform interact with catalytic and regulatory domains of ARNO (显示 CYTH2 蛋白).

  6. These results suggest that ISF/ShIF confers stromal cells with enhanced supporting activities for HSCs by modulating Wnt (显示 WNT2 蛋白)-activity and the extracellular matrix.

  7. Data demonstrate the crucial role of early endosomal acidification and V-ATPase (显示 ATP6V1H 蛋白)/ARNO (显示 CYTH2 蛋白)/Arf6 (显示 ARF6 蛋白) interactions in the regulation of the endocytic degradative pathway.

蛋白简介ATP6V0A2

蛋白简介

The protein encoded by this gene is a subunit of the vacuolar ATPase (v-ATPase), an heteromultimeric enzyme that is present in intracellular vesicles and in the plasma membrane of specialized cells, and which is essential for the acidification of diverse cellular components. V-ATPase is comprised of a membrane peripheral V(1) domain for ATP hydrolysis, and an integral membrane V(0) domain for proton translocation. The subunit encoded by this gene is a component of the V(0) domain. Mutations in this gene are a cause of both cutis laxa type II and wrinkly skin syndrome.

Alternative names and synonyms associated with ATP6V0A2

  • ATPase, H+ transporting, lysosomal V0 subunit a2 (ATP6V0A2)
  • ATPase, H+ transporting, lysosomal V0 subunit A2 (Atp6v0a2)
  • ATPase, H+ transporting, lysosomal V0 subunit a2a (atp6v0a2a)
  • 8430408C20Rik 蛋白
  • A2 蛋白
  • AI385560 蛋白
  • ARCL 蛋白
  • ARCL2A 蛋白
  • ATP6a2 蛋白
  • Atp6n1d 蛋白
  • Atp6n2 蛋白
  • atp6v0a2 蛋白
  • AW489264 蛋白
  • C76904 蛋白
  • Cc1-3 蛋白
  • ISF 蛋白
  • J6b7 蛋白
  • RTF 蛋白
  • SHIF 蛋白
  • si:ch211-199i18.4 蛋白
  • Stv1 蛋白
  • Tj6 蛋白
  • TJ6M 蛋白
  • TJ6s 蛋白
  • V-ATPase 116 kDa 蛋白
  • V-ATPase a2 蛋白
  • VPH1 蛋白
  • WSS 蛋白

Protein level used designations for ATP6V0A2

ATPase, H+ transporting, lysosomal V0 subunit a , V-type proton ATPase 116 kDa subunit a , V-type proton ATPase 116 kDa subunit a isoform 2 , vacuolar H(+)-transporting ATPase 116 kDa subunit, a2 isoform , A2V-ATPase , lysosomal H(+)-transporting ATPase V0 subunit a2 , regeneration and tolerance factor , v-ATPase 116 kDa , v-type proton ATPase 116 kDa subunit a , vacuolar proton translocating ATPase 116 kDa subunit a , V-ATPase 116 kDa , vacuolar proton translocating ATPase 116-kDa subunit a2 , ATPase, H+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 2 (38kD) , T-cell expressing clone j6 , immune suppressor factor J6B7 , ATPase, H+ transporting, lysosomal V0 subunit a2

GENE ID SPECIES
395473 Gallus gallus
23545 Homo sapiens
486245 Canis lupus familiaris
338038 Bos taurus
21871 Mus musculus
116455 Rattus norvegicus
561469 Danio rerio
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