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changes in distinct lipid ratios may converge on ARF1 to increase SBP-1 (显示 MEGF8 ELISA试剂盒)/SREBP-1 (显示 SREBF1 ELISA试剂盒) activity.
Experiments using a mutant form of ARF1 affecting GTP (显示 AK3 ELISA试剂盒) hydrolysis suggest that ARF1[GTP (显示 AK3 ELISA试剂盒)] is functionally required for the tubules to form.
ARNO-ARF1 regulates formation of podosomes by inhibition of RhoA/myosin-II and promotion of actin core assembly.
Activation of ARF1 dissociates ADRP (显示 PLIN2 ELISA试剂盒) from lipid droplets. A constitute active form of ARF1 (ARF1Q71I) promotes HCV assembly. ADRP (显示 PLIN2 ELISA试剂盒) played a positive role in Hepatitis C virus replication and negative role in Hepatitis C virus assembly.
ARF1 may reverse CAM-DR by regulating phosphorylation of p27 (显示 PAK2 ELISA试剂盒) at T157 in MM. our data shed new light on the molecular mechanism of CAM-DR in MM, and targeting ARF1 may be a novel therapeutic approach for improving the effectiveness of chemotherapy in MM.
We report here that 2-methylcoprophilinamide (M-COPA (显示 COPA ELISA试剂盒)), a compound that induces disassembly of the Golgi apparatus by inactivating ADP-ribosylation factor 1 (Arf1), suppresses Stx (显示 ST8SIA2 ELISA试剂盒)-induced apoptosis. M-COPA (显示 COPA ELISA试剂盒) inhibited transport of Stx (显示 ST8SIA2 ELISA试剂盒) from the plasma membrane to the Golgi apparatus and suppressed degradation of anti-apoptotic proteins and the activation of caspases
observations indicate that Arf1 and Arf3 (显示 ARF3 ELISA试剂盒) as well as Arf6 (显示 ARF6 ELISA试剂盒) play important roles in cytokinesis.
ARF1 activates the MAPK (显示 MAPK1 ELISA试剂盒) pathway likely using the Golgi as a main platform, which in turn activates the cytoplasmic RSK1 (显示 RPS6KA1 ELISA试剂盒), leading to cell proliferation.
Data indicate that ADP-ribosylation factor 1 (Arf1) colocalizes with chromogranin A (显示 CHGA ELISA试剂盒) and regulates secretion of insulin like growth factor 1 (IGF-1 (显示 IGF1 ELISA试剂盒)) and is required for anchorage dependent growth.
this study reports the cryo-electron microscopy structures of the Nef- and Arf1-bound AP-1 (显示 FOSB ELISA试剂盒) trimer in the active and inactive states.
ARF1 may be a plausible inter-player that mediates the transition to osteoclast fusion at multiple steps during osteoclast differentiation.
Increased gene dosage of Ink4a, Arf1 and p53 (显示 TP53 ELISA试剂盒) delays age-associated central nervous system functional decline.
ARF1/TBCE (显示 TBCE ELISA试剂盒)-mediated cross-talk that coordinates COPI formation and tubulin (显示 TUBB ELISA试剂盒) polymerization at the Golgi.
These data establish for the first time that the Arf1 gene is indispensable for mouse embryonic development after implantation.
Arf modulates LRP6 (显示 LRP6 ELISA试剂盒) phosphorylation for the transduction of Wnt (显示 WNT2 ELISA试剂盒)/beta-catenin (显示 CTNNB1 ELISA试剂盒) signaling.
Down-regulation of ADP-ribosylation factor results in corneal neovascularization regression.
ARF1-dependent trafficking of procathepsin B and the maturation of autophagosomes results in cathepsin B-mediated trypsinogen activation induced by caerulein.
Egr1 mediates p53-independent c-Myc-induced apoptosis via a noncanonical ARF-dependent transcriptional mechanism
A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signaling
termination of Arf1 signals mediated through GGA require that Arf1.GTP (显示 AK3 ELISA试剂盒) dissociates from GGA prior to interaction with GAP and consequent hydrolysis of GTP (显示 AK3 ELISA试剂盒)
findings reveal a novel signalling pathway involved in development of the semicircular canal system, and suggest a previously unrecognized role for NCS-1 (显示 NCS1 ELISA试剂盒) in mitochondrial function via its association with several mitochondrial proteins.
Vascular endothelial growth factor receptor-2 (显示 KDR ELISA试剂盒) activates ADP-ribosylation factor 1 to promote endothelial nitric-oxide synthase (显示 NOS3 ELISA试剂盒) activation and nitric oxide release from endothelial cells
Data show that AP-1 (显示 JUN ELISA试剂盒) recruitment to the cell membrane was found to be dependent on myristoylated ADP-ribosylation factor (ARF1), GTP (显示 AK3 ELISA试剂盒) or nonhydrolyzable GTP (显示 AK3 ELISA试剂盒)-analogs, tyrosine signals, and small amounts of phosphoinositides.
NCS-1 (显示 NCS1 ELISA试剂盒)-ARF1 interaction provides evidence for functional cross-talk between Ca(2 (显示 CA2 ELISA试剂盒)+)-dependent and ARF-dependent pathways in TGN (显示 TG ELISA试剂盒) to plasma membrane traffic
The ARF1 machinery also might produce movement- and fission-promoting forces through actin polymerization.
Binding of cargo signal peptides to AP-1 (显示 JUN ELISA试剂盒) induces a conformational change in its core domain that greatly enhances its interaction with Arf-1-GTP (显示 AK3 ELISA试剂盒).
Study shows that ARF DNA-binding domains ahomodimerize to generate cooperative DNA binding, which is critical for in vivo ARF5 (显示 ARF5 ELISA试剂盒)/MP function. Strikingly, DNA-contacting residues are conserved between ARFs, and found that monomers have the same intrinsic specificity; ARF1 and ARF5 (显示 ARF5 ELISA试剂盒) homodimers, however, differ in spacing tolerated between binding sites.
Data indicate that ArfGAP domain8 (AGD8) and ARF-GAP domain 9 (AGD9), are involved in the recruitment of Arf1-GDP to the Golgi apparatus .
ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.
ADP-ribosylation factor 1
, adp-ribosylation factor 1
, ADP-ribosylation factor domain protein 1