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抗Human TLR4 抗体:
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抗Rat (Rattus) TLR4 抗体:
Human Monoclonal TLR4 Primary Antibody for ChIP, CyTOF - ABIN252522
Kessel, Toubi, Pavlotzky, Mogilner, Coran, Lurie, Karry, Sukhotnik et al.: Treatment with glutamine is associated with down-regulation of Toll-like receptor-4 and myeloid differentiation factor 88 expression and decrease in intestinal mucosal injury caused by ... in Clinical and experimental immunology 2008
Show all 63 Pubmed References
Human Monoclonal TLR4 Primary Antibody for FACS - ABIN251961
Allam, Peng, Appel, Wenghoefer, Niederhagen, Bieber, Bergé, Novak: Toll-like receptor 4 ligation enforces tolerogenic properties of oral mucosal Langerhans cells. in The Journal of allergy and clinical immunology 2008
Show all 22 Pubmed References
Dog (Canine) Monoclonal TLR4 Primary Antibody for FACS - ABIN252065
Konno, Wakabayashi, Akashi-Takamura, Ishii, Kobayashi, Takahashi, Kusumoto, Saitoh, Yoshizawa, Miyake: A molecule that is associated with Toll-like receptor 4 and regulates its cell surface expression. in Biochemical and biophysical research communications 2005
Show all 24 Pubmed References
Dog (Canine) Monoclonal TLR4 Primary Antibody for BP, CyTOF - ABIN4360119
Basak, Pathak, Bhattacharyya, Mandal, Pathak, Kundu et al.: NF-kappaB- and C/EBPbeta-driven interleukin-1beta gene expression and PAK1-mediated caspase-1 activation play essential roles in interleukin-1beta release from Helicobacter pylori ... in The Journal of biological chemistry 2005
Show all 22 Pubmed References
Dog (Canine) Monoclonal TLR4 Primary Antibody for BP, CyTOF - ABIN4360113
Rallabhandi, Bell, Boukhvalova, Medvedev, Lorenz, Arditi, Hemming, Blanco, Segal, Vogel: Analysis of TLR4 polymorphic variants: new insights into TLR4/MD-2/CD14 stoichiometry, structure, and signaling. in Journal of immunology (Baltimore, Md. : 1950) 2006
Show all 44 Pubmed References
Dog (Canine) Monoclonal TLR4 Primary Antibody for FACS - ABIN4360117
Mempel, Voelcker, Köllisch, Plank, Rad, Gerhard, Schnopp, Fraunberger, Walli, Ring, Abeck, Ollert et al.: Toll-like receptor expression in human keratinocytes: nuclear factor kappaB controlled gene activation by Staphylococcus aureus is toll-like receptor 2 but not toll-like receptor 4 or platelet ... in The Journal of investigative dermatology 2003
Show all 23 Pubmed References
Human Monoclonal TLR4 Primary Antibody for BP, CyTOF - ABIN4360167
Degraaf, Zasłona, Bourdonnay, Peters-Golden: Prostaglandin E2 reduces Toll-like receptor 4 expression in alveolar macrophages by inhibition of translation. in American journal of respiratory cell and molecular biology 2014
Show all 24 Pubmed References
Dog (Canine) Monoclonal TLR4 Primary Antibody for FACS, ICC - ABIN4360164
Cognasse, Hamzeh, Chavarin, Acquart, Genin, Garraud: Evidence of Toll-like receptor molecules on human platelets. in Immunology and cell biology 2005
Show all 21 Pubmed References
Dog (Canine) Monoclonal TLR4 Primary Antibody for BP, ELISA - ABIN4360158
Scheel, Papavlassopoulos, Blunck, Gebert, Hartung, Zähringer, Seydel, Schromm: Cell activation by ligands of the toll-like receptor and interleukin-1 receptor family depends on the function of the large-conductance potassium channel MaxiK in human macrophages. in Infection and immunity 2006
Show all 18 Pubmed References
Human Monoclonal TLR4 Primary Antibody for FACS - ABIN4360193
Zanoni, Navone, Lunardi, Tridente, Bason, Sivori, Beri, Dolcino, Valletta, Corrocher, Puccetti: In celiac disease, a subset of autoantibodies against transglutaminase binds toll-like receptor 4 and induces activation of monocytes. in PLoS medicine 2006
Show all 16 Pubmed References
TLR3 (显示 TLR3 抗体) or TLR4 activation of mesenchymal stem cells increases Treg cell induction via the Notch (显示 NOTCH1 抗体) pathway
Taxol activates the TLR4-NFkappaB (显示 NFKB1 抗体) pathway which in turn induces ABCB1 (显示 ABCB1 抗体) gene expression and drug resistance in ovarian carcinoma cells.
miR (显示 MLXIP 抗体)-146a improves intestine epithelial cells survival under ischemia and I/R injury through inhibition TLR4, TRAF6 (显示 TRAF6 抗体), and p-IkappaBalpha (显示 NFKBIA 抗体), subsequently leading to decreased NF-kappaB (显示 NFKB1 抗体) p65 (显示 GORASP1 抗体) nuclear translocation.
ITGalpha4beta1 and TLR4 have roles in inducing fibrotic gene expression in response to fibronectin's EDA (显示 EDA 抗体) domain
our study suggested that both death receptors and mitochondial were involved in TLR4-induced cell death, and TAP63alpha may be a target for the prevention of LPS (显示 IRF6 抗体)-induced cell death.
Expression of TLR4/MD2 (显示 LY96 抗体)/CD14 (显示 NDUFA2 抗体) is required for casein alpha S1 (显示 CSN1S1 抗体)-induced proinflammatory effects. TLR4 blockade inhibits casein alpha S1 (显示 CSN1S1 抗体) induced proinflammatory cytokine expression.
This study investigated the effects of DYN (显示 SPTBN4 抗体) 3-14 on lipopolysaccharide (LPS (显示 IRF6 抗体))-induced nuclear factor-kappaB/p65 (NF-kappaB/p65 (显示 NFkBP65 抗体)) nuclear translocation.These findings indicate that DYN (显示 SPTBN4 抗体) 3-14 is a potential TLR4 antagonist that alters cellular signaling in response to LPS (显示 IRF6 抗体) and cytokine release, implicating a role for biotransformed endogenous opioid peptides in immunomodulation.
The present meta-analysis suggests that the TLR4 Asp299Gly polymorphism was not associated with decreased coronary heart disease risk in Caucasians.
We found that D299G and T399I SNPs were associated with Crohn's Disease susceptibility in patients carrying NOD2 (显示 NOD2 抗体) variants. The patients carrying any mutant TLR4 variant were predisposed to develop a stricturing disease, especially in the presence of NOD2 (显示 NOD2 抗体) mutation.
We have identified intronic TLR4 SNPs as genetic susceptibility alleles for POAG in a Mexican population. Our findings support the association of the TLR4 gene with primary open angle glaucoma.
Quercetin reverted gut (显示 GUSB 抗体) microbiota imbalance and related endotoxemia-mediated TLR-4 pathway induction, with subsequent inhibition of inflammasome response and reticulum stress pathway activation, leading to the blockage of lipid metabolism gene expression deregulation.
Soyasaponin Bb can inhibit TLR4 recruitment into lipid rafts and its signaling by suppressing the NADPH oxidase (显示 NOX1 抗体)-dependent reactive oxygen species generation.
TLR4 signaling was essential for the induction of antigen-specific Th1 (显示 HAND1 抗体) immune responses elicited by OMLs.
Inhibition of TLR4 ameliorates AngII-impaired cavernosal relaxation, decreases TNF-alpha (显示 TNF 抗体) levels, and restores Nitric Oxide bioavailability, demonstrating that TLR4 partly mediates AngII-induced cavernosal dysfunction.
hyperresponsive promoter engaged the RelA:p52 dimer generated during costimulation of macrophages through TLR4 and LTbetaR to trigger synthesis of IkappaBalpha (显示 NFKBIA 抗体) at late time points, which prevented the late-acting RelA (显示 NFkBP65 抗体) cross-talk response.
BCG (显示 SLC11A1 抗体) increased membrane expression of TRIM59 through the TLR2 (显示 TLR2 抗体)/ TLR4/IRF5 (显示 IRF5 抗体) pathway in RAW264.7 macrophage cell line.
M. scrofulaceum induces a semimature DC phenotype that is characterized by PD-L2 (显示 PDCD1LG2 抗体) over-expression and elevated synthesis of IL-10 (显示 IL10 抗体), most likely through TLR4 and Raf-1 (显示 RAF1 抗体) signaling pathway-dependent DC-SIGN (显示 CD209 抗体) stimulation.
TLR4 deficiency prevented indomethacin-induced small intestinal damage
This study supports a role for TLR2 (显示 TLR2 抗体) and TLR4 in periodontal disease and atherosclerosis, corroborating an intricate association between two inflammatory diseases.
Hemorrhagic shock primes for lung vascular endothelial cell pyroptosis following lipopolysaccharide exposure through TLR4, which activates Nlrp3 (显示 NLRP3 抗体), and subsequently induces caspase-1 (显示 CASP1 抗体) activation.
STA3 (显示 ARHGEF3 抗体) facilitates TLR4-dependent IL-6 (显示 IL6 抗体) and IL-8 (显示 IL8 抗体) production via IL-6 (显示 IL6 抗体) receptor-positive feedback in endometrial cells.
Studied genetic diversity of the Toll-like receptor gene TLR4 in Czech Red and Czech Red Pied cattle. Found 8 SNPs, which were grouped into 18 haplotypes.
TLR4 polymorphisms are associated with lower reproductive Performance.
As a pilot study, the present results revealed that identified SNPs in IL8 (显示 IL8 抗体) and TLR4 genes can be used as a genetic marker and predisposing factor for resistance/susceptibility to digital dermatitis in dairy cows. However, TLR4 gene may be a potential candidate for such disease.
Transcription levels of TLR2 (显示 TLR2 抗体), TLR4, and CD14 (显示 CD14 抗体) in Holstein cows with retained placenta significantly decreased between the first and the seventh day postpartum.
Bovine viral diarrhea virus type 2 infection modulates TLR4 responsiveness in differentiated myeloid cells.
TLR2 (显示 TLR2 抗体) and TLR4 mediate innate response against Cryptosporidium parvum in bovine intestinal epithelial cells.
TLR4 polymorphisms are associated with susceptibility to Mycobacterium avium ssp. paratuberculosis infection in Holsteins
positive correlation between lower neutrophil apoptosis and higher expression of TLR2 (显示 TLR2 抗体) and TLR4 with the formation of NETs and change in surface architecture.
Studied SNPs in the bovine toll-like receptor 4 (TLR4) and monocyte chemo attractant protein-1(CCL2 (显示 CCL2 抗体)) genes.
TLR2 (显示 TLR2 抗体), 3, 4, and 8 mRNA expression is strongly upregulated and correlates with the progression of atherosclerosis in the aorta. Fluvastatin significantly inhibited this progress and reduced inflammation via TLR downregulation.
The expression of TLR4 protein and mRNA, the level of activated NF-kappaB (显示 NFKB1 抗体) (p65 (显示 SYT1 抗体)) were respectively detected.
Lipopolysaccharide upregulates the expression of rabbit TLR2 (显示 TLR2 抗体) and 4 in the uterine body and horn, and the expression of TLR4 in the ovary.
Polydatin might have a protective effect on lung ischemia/reperfusion injury by down-regulating TLR4 and NF-kappaB (显示 NFKB1 抗体) expression, then inhibiting the release of mediators of inflammation as ICAM-1 (显示 ICAM1 抗体).
TLR4 expression is upregulated in the brain after experimental subarachnoid haemorrhage
The elevated expression of TLR4 was detected after SAH (显示 ACSM3 抗体) and peaked on day 3 and 5. TLR4 is increasingly expressed in a parallel time course to the development of cerebral vasospasm in a rabbit experimental model of SAH (显示 ACSM3 抗体).
These results further confirm the involvement of the TLR4 signaling pathway in resistance to E. coli F18 (显示 MAMLD1 抗体) in Meishan weaned piglets.
Data suggest expression of TLR4 and NFKB (nuclear factor kappa B) are regulated by dietary factors affecting innate immunity; here, Lactobacillus acidophilus in feed down-regulates expression of TLR4 and NFKB in mononuclear cells after LPS (显示 IRF6 抗体) challenge.
At 30 days after autotransplantation of a pig kidney, mRNA expression increases for TLR4.
Data suggest TLR2 (显示 TLR2 抗体), TLR4, and calcium signaling in enterocytes play principal roles in mucosal immunity against enterotoxigenic Escherichia coli; probiotic Lactobacillus delbrueckii and its extracellular polysaccharides appear to stimulate TLR2 (显示 TLR2 抗体)/TLR4.
TLR2 (显示 TLR2 抗体) is required for the suppression of TLR4 signaling activation.
The current study screened for single nucleotide polymorphisms (SNPs) in the TLR4 gene and tested their association with Salmonella fecal shedding.
The role of TLR2 (显示 TLR2 抗体), TLR4 and RP105 (显示 CD180 抗体)/MD1 (显示 LY86 抗体) in the immunoregulatory effect of acidic exopolysaccharides from Lactobacillus plantarum N14 (显示 CLPTM1 抗体), is reported.
Data suggest expression of TLR4 in liver can be regulated by dietary factors; here, supplementation with aspartate down-regulates expression of TLR4 in liver in a model of liver disease.
Fish Oil attenuates the activation of the HPA (显示 HPSE 抗体) axis induced by LPS (显示 IRF6 抗体) challenge. So it may be associated with decreasing the production of brain or peripheral proinflammatory cytokines through inhibition of TLR4 and NOD signaling pathways in weaned pigs.
Single nucleotide polymorphisms in TLR4 is associated with immune response to gram-negative bacterial infections.
The research findings suggest that Th17 cells are involved in active equine inflammatory bowel disease, and that TLR4 expression was increased in affected horses.
A low steady expression of TLR4, MD-2 (显示 LY96 抗体) and CD14 (显示 CD14 抗体) mRNA was demonstrated for the intestinal samples with no variation between the intestinal segments analysed.
In the present study, the authors show that TLR4 expression is significantly decreased following the exogenous expression of BPV-1 E2 and E7 in primary equine fibroblasts.
evidence that pulmonary intravascular macrophages are equipped with TLR4 to handle and rapidly respond to circulating endotoxins
TLR4/MD-2 (显示 LY96 抗体) complex is responsible for recognition of Rhodococcus spheroides lipopolysaccharide as an agonist in equine cells.
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene.
, homolog of Drosophila toll
, lipopolysaccharide response
, Toll-like receptor4 protein
, Toll-like receptor 4-like protein