Use your antibodies-online credentials, if available.
Data show that Toll (显示 TLR4 ELISA试剂盒)/IL-1R domain-containing adaptor molecule (TICAM)-2 possesses two conserved acidic amino acids, D91 and E92, which regulate TICAM-2 self-activation and signaling.
Findings were SNPs in TICAM2 (P = 3.6 x 10(-6)) and IL1B (显示 IL1B ELISA试剂盒) (P = 4.3 x 10(-5)) associated with TB.
TRAM (显示 TRAM1 ELISA试剂盒) plays a role in TLR7 (显示 TLR7 ELISA试剂盒) signaling through a novel signaling axis towards the activation of anti-viral immunity.
TRAM (显示 TRAM1 ELISA试剂盒) acts as a sorting adaptor not only for TLR4 (显示 TLR4 ELISA试剂盒), but also for TLR2 (显示 TLR2 ELISA试剂盒), to facilitate signaling to IRF7 (显示 IRF7 ELISA试剂盒) at the endosome, which explains how TLR2 (显示 TLR2 ELISA试剂盒) is capable of causing type I IFN induction.
A putative TRAF6 (显示 TRAF6 ELISA试剂盒)-binding motif in TRAM (显示 TRAM1 ELISA试剂盒) may mediate a new TRAM (显示 TRAM1 ELISA试剂盒) function in TLR4 (显示 TLR4 ELISA试剂盒) signaling in regulating inflammatory responses, distinct from its bridging TLR4 (显示 TLR4 ELISA试剂盒) and TRIF (显示 TRIM69 ELISA试剂盒). A TRAM (显示 TRAM1 ELISA试剂盒) E183A mutation abolished this.
results suggest TLR adaptor molecules knockdown, such as MyD88 (显示 MYD88 ELISA试剂盒) or TRAM (显示 TRAM1 ELISA试剂盒), can decrease IL-6 (显示 IL6 ELISA试剂盒) and IL-8 (显示 IL8 ELISA试剂盒) mRNA and increase CXCL12 (显示 CXCL12 ELISA试剂盒) mRNA expression in HGF (显示 HGF ELISA试剂盒) and HPDLF.
The homotypic interaction between TICAM-2 TIR is indispensable to present a scaffold for recruiting the monomeric moiety of the TICAM-1 (显示 TICAM1 ELISA试剂盒) TIR dimer.
induction of both IL-6 (显示 IL6 ELISA试剂盒) and IL-8 (显示 IL8 ELISA试剂盒) is associated with elevated TIRAP (显示 TIRAP ELISA试剂盒) and reduced TRAM (显示 TRAM1 ELISA试剂盒) mRNA expression
Data indicate that MyD88 works together with the IL-1/IL-18 receptors, can interact with two distinct sorting adaptors, TRAM and Mal, in a conserved manner.
viral inhibitor peptide of TLR4 (显示 TLR4 ELISA试剂盒) possibly represents a surface domain of A46 that specifically inhibits TLR4 (显示 TLR4 ELISA试剂盒) by masking critical binding sites on MyD88 adaptor (显示 MYD88 ELISA试剂盒)-like and TRIF-related adaptor molecule
Distinct mechanisms downstream of TLR4 (显示 TLR4 ELISA试剂盒) signaling mediate myelosuppression and hematopoietic stem cell exhaustion during sepsis through unique effects of MyD88 (显示 MYD88 ELISA试剂盒) and TRIF (显示 RNF138 ELISA试剂盒).
these data show that both Myd88 (显示 MYD88 ELISA试剂盒) and TRIF (显示 RNF138 ELISA试剂盒) are necessary for Th17 differentiation in the lungs in response to immunization with lipopolysaccharide
these studies reveal an additional regulatory function of TRIM8 (显示 TRIM8 ELISA试剂盒) in innate immune responses: TRIM8 (显示 TRIM8 ELISA试剂盒) catalyzes polyubiquitination of TRIF (显示 RNF138 ELISA试剂盒), resulting in disruption of TRIF (显示 RNF138 ELISA试剂盒)-TBK1 (显示 TBK1 ELISA试剂盒) interaction
Stimulation of the TLR4 (显示 TLR4 ELISA试剂盒)-TRIF (显示 RNF138 ELISA试剂盒) pathway can protect against the development of allergic airway disease and that a TRIF (显示 RNF138 ELISA试剂盒)-dependent adjuvant effect on CD4 (显示 CD4 ELISA试剂盒)(+) ICOS (显示 ICOS ELISA试剂盒)(+) T-cell responses may be a contributing mechanism.
Monophosphoryl lipid A stimulation of a TLR4 (显示 TLR4 ELISA试剂盒)-TRIF (显示 RNF138 ELISA试剂盒)-PI3K-Akt (显示 AKT1 ELISA试剂盒) pathway prevents lipopolysaccharide-induced ERK (显示 EPHB2 ELISA试剂盒) activation in the medullar thick ascending limb.
study reporst a key role for TNF (显示 TNF ELISA试剂盒)/TNFR1 (显示 TNFRSF1A ELISA试剂盒) in Yersinia-induced cell death of murine macrophages, which occurs despite the blockade of NF-kappaB (显示 NFKB1 ELISA试剂盒) and MAPK (显示 MAPK1 ELISA试剂盒) signaling imposed by Yersinia on infected cells
STING and TRIF (显示 RNF138 ELISA试剂盒) Contribute to Mouse Sepsis, Depending on Severity of the Disease Model
the role of Toll (显示 TLR4 ELISA试剂盒)-like receptor (TLR) 2 (显示 TLR2 ELISA试剂盒), TLR4 (显示 TLR4 ELISA试剂盒), myeloid differentiation response gene 88, and Toll (显示 TLR4 ELISA试剂盒)-IL-1 (显示 IL1A ELISA试剂盒) receptor domain-containing adaptor-inducing interferon-gamma (显示 IFNG ELISA试剂盒) (TRIF (显示 RNF138 ELISA试剂盒)), factors critically involved in the TLR signaling pathway, was studied in experimental autoimmune neuritis.
Juniperus rigida Sieb. extract inhibits macrophage inflammatory responses by attenuating TRIF (显示 RNF138 ELISA试剂盒)-dependent signaling and inflammasome activation.
TRIF (显示 RNF138 ELISA试剂盒)-independent pathways can be involved in the downregulation of drug metabolizing enzymes and transporters through TLR4 (显示 TLR4 ELISA试剂盒) and 3. JNK (显示 MAPK8 ELISA试剂盒)-dependent mechanisms likely mediate this downregulation.
TIRP is a Toll/interleukin-1 receptor (IL1R\; MIM 147810) (TIR) domain-containing adaptor protein involved in Toll receptor signaling (see TLR4\; MIM 603030).
NF-kappa-B-activating protein 502
, TIR domain-containing adapter molecule 2
, TRIF-related adaptor molecule
, cytoplasmic adaptor
, putative NF-kappa-B-activating protein 502
, toll-like receptor adaptor protein 3
, toll/interleukin-1 receptor (TIR) domain-containing adapter protein
, TRIF-related adapter molecule
, TMED7-TICAM2 readthrough
, TIR domain-containing adapter protein
, TRIF-related adapter molecule TRAM
, Toll-interleukin I receptor domain (TIR)-containing adaptor molecule (TICAM) 2
, toll/interleukin-1 receptor domain-containing protein