anti-TANK-Binding Kinase 1 (TBK1) 抗体产品概述

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anti-TANK-Binding Kinase 1 抗体 (TBK1)
在www.antibodies-online.cn可供156 TANK-Binding Kinase 1 (TBK1) 抗体的30不同的供货商。 再加上,我们可以发TANK-Binding Kinase 1 试剂盒 (15)TANK-Binding Kinase 1 蛋白 (11)和数多这个蛋白质的别的产品。 总共192 TANK-Binding Kinase 1产品已列进来了。
别名:
1200008B05Rik, AI462036, AW048562, NAK, T2K, TBK1, wu:fk70c05, zgc:136548

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  1. Cow (Bovine) Monoclonal TBK1 Primary Antibody for ICC, IF - ABIN252648 : Merimi, Klener, Szynal, Cleuter, Kerkhofs, Burny, Martiat, Van den Broeke: Suppression of viral gene expression in bovine leukemia virus-associated B-cell malignancy: interplay of epigenetic modifications leading to chromatin with a repressive histone code. in Journal of virology 2007 (PubMed)
    Show all 20 references for 252648

  2. Human Polyclonal TBK1 Primary Antibody for EIA, IHC (p) - ABIN360254 : Deng, Shi, Han, Zhong, Li, Li, Hu, Yan, Wang, He, Tang, Deubel, Luo, Ning, Sun: Negative regulation of virus-triggered IFN-beta signaling pathway by alternative splicing of TBK1. in The Journal of biological chemistry 2008 (PubMed)
    Show all 3 references for 360254

  3. Human Monoclonal TBK1 Primary Antibody for WB - ABIN967614 : Kishore, Huynh, Mathialagan, Hall, Rouw, Creely, Lange, Caroll, Reitz, Donnelly, Boddupalli, Combs, Kretzmer, Tripp: IKK-i and TBK-1 are enzymatically distinct from the homologous enzyme IKK-2: comparative analysis of recombinant human IKK-i, TBK-1, and IKK-2. in The Journal of biological chemistry 2002 (PubMed)
    Show all 2 references for 967614

  4. Cow (Bovine) Polyclonal TBK1 Primary Antibody for WB - ABIN2785953 : Morton, Hesson, Peggie, Cohen: Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma. in FEBS letters 2008 (PubMed)

  5. Human Polyclonal TBK1 Primary Antibody for WB - ABIN151881 : Xie, Zhang, Zhao, Lu, You, Condorelli, Wang, Guan: IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation. in Proceedings of the National Academy of Sciences of the United States of America 2011 (PubMed)

更多抗TANK-Binding Kinase 1的相互作用对抗体

Zebrafish TANK-Binding Kinase 1 (TBK1) interaction partners

  1. Fish IRF6 (显示 IRF6 抗体) is distinguished from the homolog of mammals by being a positive regulator of IFN transcription and phosphorylated by MyD88 (显示 MYD88 抗体) and TBK1, suggesting that differences in the IRF6 (显示 IRF6 抗体) regulation pattern exist between lower and higher vertebrates.

Human TANK-Binding Kinase 1 (TBK1) interaction partners

  1. High TBK1 expression is associated with normal tension glaucoma.

  2. We identified novel genomic TBK1 variants including two loss-of-function (LoF) (p.Leu59Phefs*16 and c.358+5G>A), two missense (p.Asp118Asn and p.Ile397Thr) and one intronic variant (c.1644-5_1644-2delAATA).

  3. Mutations in the TANK-binding kinase 1 (TBK1) gene were identified as a cause for amyotrophic lateral sclerosis (ALS (显示 IGFALS 抗体)) with or without comorbid frontotemporal dementia.

  4. The occurrence of TBK1 mutations in FTD (显示 FTL 抗体) and ALS (显示 IGFALS 抗体) underlines the fact that FTD (显示 FTL 抗体) and ALS (显示 IGFALS 抗体) are part of the same disease spectrum. For future therapeutic trials, characterization of TBK1 mutation carriers in presymptomatic cohorts, such as the genetic frontotemporal dementia initiative (GENFI), is of great importance.

  5. demonstrate a key role of TBK1/IKKepsilon (显示 IKBKE 抗体) in the survival and proliferation of HTLV-1-transformed T cells

  6. Data suggest that Encephalomyocarditis virus 3C protease cleaves TANK and disrupts the TANK-TBK1-IKKepsilon (显示 IKBKE 抗体)-IRF3 (显示 IRF3 抗体) complex, resulting in reduction in IRF3 (显示 IRF3 抗体) phosphorylation and type I interferon (显示 IFNA 抗体) production. (TANK = TRAF family member associated NFKB activator (显示 TANK 抗体); TBK1 = TANK binding kinase 1; IKKepsilon (显示 IKBKE 抗体) = inhibitor of nuclear factor kappa B kinase subunit epsilon (显示 IKBKE 抗体); IRF3 (显示 IRF3 抗体) = interferon regulatory factor 3 (显示 IRF3 抗体))

  7. Data suggest that changes in inhibitor of nuclear factor kappa B kinase subunit epsilon (IKKepsilon (显示 IKBKE 抗体)) and TANK-binding kinase 1 (TBK1) expression may be involved in the development of intestinal-type gastric cancer.

  8. Here the authors show that recruitment of WIPI2 (显示 WIPI2 抗体), itself essential for anti-bacterial autophagy, is dependent on the localization of catalytically active TBK1 to the vicinity of cytosolic bacteria.

  9. review of the role of TBK1 in the seemingly unrelated, yet allelic diseases amyotrophic lateral sclerosis (ALS (显示 IGFALS 抗体)), frontotemporal dementia (FTD (显示 FTL 抗体)), normal tension glaucoma (NTG (显示 OPA1 抗体)) and childhood herpes simplex encephalitis and discuss the role of TBK1 in neuroinflammatory diseases

  10. Enrichment of qualifying variants toward glaucoma was present in all genes except WDR36 (显示 WDR36 抗体), in which controls harbored more variants, and TBK1, in which no qualifying variants were detected in cases or controls.

Mouse (Murine) TANK-Binding Kinase 1 (TBK1) interaction partners

  1. these studies reveal an additional regulatory function of TRIM8 (显示 TRIM8 抗体) in innate immune responses: TRIM8 (显示 TRIM8 抗体) catalyzes polyubiquitination of TRIF (显示 RNF138 抗体), resulting in disruption of TRIF (显示 RNF138 抗体)-TBK1 interaction

  2. TBK1 regulates p16 (显示 CDKN2A 抗体) expression and retinal ganglion cell senescence.

  3. USP38 inhibits type I interferon (显示 IFNA 抗体) signaling by editing TBK1 ubiquitination through NLRP4 signalosome.

  4. The authors report that Raf kinase inhibitory protein (RKIP (显示 PEBP1 抗体)) is essential for TBK1 activation and type I interferon (显示 IFNA 抗体) production triggered by viral infection.

  5. Upon stimulation with poly(I:C), malaria parasite-infected red blood cells (iRBCs), or vesicular stomatitis virus (VSV), FOSL1 (显示 FOSL1 抗体) "translocated" from the nucleus to the cytoplasm, where it inhibited the interactions between TNF receptor-associated factor 3 (TRAF3 (显示 TRAF3 抗体)), TIR domain-containing adapter inducing IFN-beta (显示 IFNB1 抗体) (TRIF (显示 RNF138 抗体)), and Tank-binding kinase 1 (TBK1) via impairing K63-linked polyubiquitination of TRAF3 (显示 TRAF3 抗体) and TRIF (显示 RNF138 抗体).

  6. TBK1 complexes required for the phosphorylation of IRF3 (显示 IRF3 抗体) and the production of interferon-beta (显示 IFNB1 抗体) have been identified.

  7. this study reveals a previously unknown ICOS (显示 ICOS 抗体)-TBK1 signaling pathway that specifies the commitment of germinal center follicular helper T cells

  8. Innate immune responses to adenovirus vectors are largely TBK1-dependent in the spleen but TBK1-independent in the liver

  9. Data show that the formation of a tripartite ribosomal protein S6 kinase 1 (S6K1 (显示 RPS6KB1 抗体))-STING membrane protein-TANK-binding kinase 1 (TBK1) complex was necessary for the activation of interferon regulatory factor-3 (IRF3 (显示 IRF3 抗体)).

  10. This study suggest that TBK1 exerts pronociceptive effects in inflammatory nociception which are due to both modulation of NF-kappaB dependent genes and regulation of MAPKs and c-fos.

TANK-Binding Kinase 1 (TBK1) 抗原简介

Antigen Summary

The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors.

Alternative names and synonyms associated with TANK-Binding Kinase 1 (TBK1)

  • TANK-binding kinase 1 (tbk1) 抗体
  • TANK-binding kinase 1 (TBK1) 抗体
  • TANK-binding kinase 1 (LOC100358771) 抗体
  • TANK-binding kinase 1 (Tbk1) 抗体
  • 1200008B05Rik 抗体
  • AI462036 抗体
  • AW048562 抗体
  • NAK 抗体
  • T2K 抗体
  • TBK1 抗体
  • wu:fk70c05 抗体
  • zgc:136548 抗体

Protein level used designations for TBK1

serine/threonine-protein kinase TBK1 , TANK-binding kinase 1 , NF-kappa-B-activating kinase , TANK binding kinase 1 , serine/threonine protein kinase TBK1 , serine/threonine-protein kinase TBK1-like , NF-kB-activating kinase , T2K

GENE ID SPECIES
446351 Xenopus laevis
452047 Pan troglodytes
692289 Danio rerio
717427 Macaca mulatta
100051650 Equus caballus
100125828 Sus scrofa
100216212 Xenopus (Silurana) tropicalis
100358771 Oryctolagus cuniculus
100399701 Callithrix jacchus
100433568 Pongo abelii
100484104 Ailuropoda melanoleuca
100553575 Anolis carolinensis
100582856 Nomascus leucogenys
29110 Homo sapiens
481145 Canis lupus familiaris
533141 Bos taurus
56480 Mus musculus
299827 Rattus norvegicus
417825 Gallus gallus
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