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抗Human TAB3 抗体:
抗Mouse (Murine) TAB3 抗体:
抗Rat (Rattus) TAB3 抗体:
Our study provides insights into the mechanism of TAB3 regulating activity and suggests its important implications in triple negative breast cancer metastasis.
Data show that knockdown of transforming growth factor-activated kinase 1 (TAK1)-binding protein 3 (TAB3) inhibited proliferation of non-small cell lung cancer (NSCLC) cells.
TAB3 regulated ovarian cancer cell bioactivity and chemotherapy performance via the NF-kappaB (显示 NFKB1 抗体) pathway.
Upregulation of miR (显示 MLXIP 抗体)-532-5p and subsequent suppression of the SESTD1 (显示 SESTD1 抗体) and TAB3 genes represent an antiviral response aimed at limiting West Nile virus infection.
miR (显示 MLXIP 抗体)-30a in MSCs may participate in the immune dysregulation of the maternal-fetal interface during PE
miR (显示 MLXIP 抗体)-26b suppresses NF-kappaB (显示 NFKB1 抗体) signaling and sensitizes hepatocellular carcinoma cells to doxorubicin-induced apoptosis by inhibiting the expression of TAK1 (显示 MAP3K7 抗体) and TAB3.
conclude that TRIM38 (显示 TRIM38 抗体) negatively regulates TNFalpha (显示 TNF 抗体)- and IL-1beta (显示 IL1B 抗体)-induced signaling by mediating lysosome-dependent degradation of TAB2 (显示 TAB2 抗体)/3, two critical components in TNFalpha (显示 TNF 抗体)- and IL-1beta (显示 IL1B 抗体)-induced signaling pathways
Studies show that three proteins expressed in HEK (显示 EPHA3 抗体)-293T cells (NAP1 (显示 IL8 抗体), TANK and TBKBP1 (显示 TBKBP1 抗体)) interact with TBK1 (显示 TBK1 抗体).
MiR (显示 MLXIP 抗体)-23b suppresses IL-17 (显示 IL17A 抗体)-, tumor necrosis factor alpha (TNF-alpha (显示 TNF 抗体))- or IL-1beta (显示 IL1B 抗体)-induced NF-kappaB (显示 NFKB1 抗体) activation and inflammatory cytokine expression by targeting TAB2 (显示 TAB2 抗体), TAB3 and IKK-alpha (显示 CHUK 抗体).
human TAB2 (显示 TAB2 抗体) and TAB3, ubiquitin-chain sensory proteins involved in NF-kappaB (显示 NFKB1 抗体) signalling, are directly inactivated by enteropathogenic Escherichia coli NleE, a conserved bacterial type-III-secreted effector responsible for blocking host NF-kappaB (显示 NFKB1 抗体) signalling
Findings indicate that the absence of TAB3 plays a harmful role in ischemic heart disease
TAB2 (显示 TAB2 抗体) and TAB3 are essential for B cell activation (显示 BLNK 抗体) leading to antigen-specific antibody responses, as well as B-1 and marginal zone B cell development.
The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
TGF-beta activated kinase 1/MAP3K7 binding protein 3
, mitogen-activated protein kinase kinase kinase 7-interacting protein 3-like
, NF-kappa-B-activating protein 1
, NFkB activating protein 1
, TAK1-binding protein 3
, TGF-beta-activated kinase 1 and MAP3K7-binding protein 3
, TGF-beta-activated kinase 1-binding protein 3
, mitogen-activated protein kinase kinase kinase 7 interacting protein 3
, mitogen activated protein kinase kinase kinase 7 interacting protein 3
, mitogen-activated protein kinase kinase kinase 7-interacting protein 3