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results demonstrate that Sphingosine 1-phosphate lyase (SPL (显示 SGPL1 ELISA试剂盒)) is a host factor that augments type I IFN responses during influenza A virus infection; study delineates the relationship between IKKepsilon and SPL (显示 SGPL1 ELISA试剂盒), which provides a mechanistic understanding of the pro-IFN activity of SPL (显示 SGPL1 ELISA试剂盒)
Virus-activated kinase IKKepsilon phosphorylated YAP (显示 YAP1 ELISA试剂盒) at Ser403 and thereby triggered degradation of YAP (显示 YAP1 ELISA试剂盒) in lysosomes and, consequently, relief of YAP (显示 YAP1 ELISA试剂盒)-mediated inhibition of the cellular antiviral response.
We then determined that YAP1 (显示 YAP1 ELISA试剂盒) negatively regulates miR (显示 MLXIP ELISA试剂盒)-let-7b/i by overexpressing and silencing YAP1 (显示 YAP1 ELISA试剂盒) expression. In addition, miR (显示 MLXIP ELISA试剂盒)-let-7b/i feedback decreases the expression of IKBKE and YAP1 (显示 YAP1 ELISA试剂盒) and suppresses the transportation of YAP1 (显示 YAP1 ELISA试剂盒) located in the nucleus. Therefore, the regulatory feedback circuit of IKBKE upward arrow-->YAP1 (显示 YAP1 ELISA试剂盒) upward arrow-->miR (显示 MLXIP ELISA试剂盒)-let-7b/i downward arrow-->IKBKE upward arrow dictates glioblastoma progress...
our findings highlight the functional importance of IKBKE in pancreatic cancer
we define a pathobiologic function for IKKepsilon in reprogramming glucose metabolism and driving progression in pancreatic ductal adenocarcinoma
demonstrate a key role of TBK1 (显示 TBK1 ELISA试剂盒)/IKKepsilon in the survival and proliferation of HTLV-1-transformed T cells
Data suggest that changes in inhibitor of nuclear factor kappa B kinase subunit epsilon (IKKepsilon) and TANK-binding kinase 1 (TBK1 (显示 TBK1 ELISA试剂盒)) expression may be involved in the development of intestinal-type gastric cancer.
Live NiV infection, but not a recombinant NiV lacking the M protein (显示 MYOM2 ELISA试剂盒), reduced the levels of endogenous TRIM6 (显示 TRIM6 ELISA试剂盒) protein expression. To our knowledge, matrix proteins of paramyxoviruses have never been reported to be involved in innate immune antagonism. We report here a novel mechanism of viral innate immune evasion by targeting TRIM6 (显示 TRIM6 ELISA试剂盒), IKKepsilon and unanchored polyubiquitin (显示 UBB ELISA试剂盒) chains.
The adaptor molecule RAIDD (显示 CRADD ELISA试剂盒) coordinates IKKepsilon and IRF7 (显示 IRF7 ELISA试剂盒) interaction to ensure efficient expression of type I interferon (显示 IFNA ELISA试剂盒).
These findings collectively support the conclusion that IKK (显示 CHUK ELISA试剂盒) modulates innate immune signaling cascades via phosphorylating the RIG-I (显示 DDX58 ELISA试剂盒) cytosolic sensor, providing a feedback regulatory mechanism.
REGgamma-mediated control of IkappaBvarepsilon contributes to NFkappaB activation and promotes bowel inflammation and associated tumour formation in response to chronic injury
Suggest that by reducing production of cAMP in adipocytes, PDE3B, IKKepsilon and TBK1 (显示 TBK1 ELISA试剂盒) may contribute to the repression of energy expenditure during obesity.
A role for APPL1 (显示 APPL1 ELISA试剂盒) in TLR3 (显示 TLR3 ELISA试剂盒)/4-dependent TBK1 (显示 TBK1 ELISA试剂盒) and IKKepsilon activation in macrophages.
The results highlight the importance of the C-terminal region in the functional activity of IKKepsilon in innate immune response
tic (显示 ARNTL ELISA试剂盒) ablation of IKBKE resulted in enhanced and prolonged priming of the NLRP3 (显示 NLRP3 ELISA试剂盒) inflammasome in cultured macrophages, in hypertrophic adipose tissue, and in livers of hypercholesterolemic mice.
novel insight into IKKepsilon, which is involved in adipose tissue inflammation during the development of obesity
miR (显示 MLXIP ELISA试剂盒)-339-5p inhibits expression of the pro-inflammatory factors in alcohol-induced brain inflammation through the NF-kappaB (显示 NFKB1 ELISA试剂盒) pathway by abolishing IKK-beta (显示 IKBKB ELISA试剂盒) and IKK-epsilon activity.
IKKepsilon deficiency inhibits inflammation and induces cardiac protection in high-fat diet-induced obesity in mice.
IKKepsilon is expressed in neurons and is upregulated in the hypothalamus of obese mice, contributing to insulin (显示 INS ELISA试剂盒) and leptin (显示 LEP ELISA试剂盒) resistance.
IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
, inhibitor of nuclear factor kappa-B kinase subunit epsilon
, inhibitor of nuclear factor kappa-B kinase subunit epsilon-like
, I-kappa-B kinase epsilon
, IKK-related kinase epsilon
, inducible I kappa-B kinase
, inducible IkappaB kinase
, inhibitor of kappaB kinase epsilon
, inducible IKappaB kinase