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xPontin and xReptin are essential genes regulating cell proliferation in early Xenopus embryogenesis through interaction with c-Myc (显示 MYC ELISA试剂盒)
Reptin silencing did not affect the tyrosine phosphorylation of the insulin receptor (显示 INSR ELISA试剂盒) nor of IRS1 (显示 IRS1 ELISA试剂盒), but it enhanced the tyrosine phosphorylation of the p85 subunit of PI3K (显示 PIK3CA ELISA试剂盒).
Overall, POLG (显示 POLG ELISA试剂盒) interactome mapping identifies novel proteins which support mitochondrial biogenesis and a potential novel mitochondrial isoform of Ruvbl2.
The authors report that HIV-1 exploits the host factor RuvB-like 2 (RVB2) to balance relative expression of Gag and Env for efficient production of infectious virions.
by means of molecular docking approaches we first modeled the structures of hetero-hexameric TIP49 ( TIP49a and TIP49b )complexes with short ds-DNA fragments (20 base pairs with different GC content) within the central channel of hexameric ring
Data suggest that overexpression of Reptin in hepatocellular carcinoma (HCC (显示 FAM126A ELISA试剂盒)) could be a factor of resistance to treatment.
RuvbL1 and RuvbL2 enhance aggresome formation and disaggregate amyloid fibrils.
results reveal a novel mechanism for the control of NF-kappaB (显示 NFKB1 ELISA试剂盒) pathway by cytoplasmic Reptin
The results suggests that a potential mechanism for the role of RuvBL1-RuvBL2 in maintaining genome integrity is through controlling the cellular abundance of Fanconi anaemia core complex.
Reptin and Pontin oligomerization and activity are modulated through histone H3 N-terminal tail interaction.
these findings suggest that YY1 (显示 YY1 ELISA试剂盒)-RuvBL1-RuvBL2 complexes could contribute to functions beyond transcription, and we show that YY1 (显示 YY1 ELISA试剂盒) and the ATPase (显示 DNAH8 ELISA试剂盒) activity of RuvBL2 are required for RAD51 (显示 RAD51 ELISA试剂盒) foci formation during homologous recombination.
the Reptin-Lrrc6/Seahorse (显示 LRRC6 ELISA试剂盒) complex is involved in dynein arm formation.
the reptin/pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin (显示 CTNNB1 ELISA试剂盒) pathway
Ruvbl2 has a role in the differentiation of neuroectoderm during early embryogenesis.
accumulating E2f1 (显示 E2F1 ELISA试剂盒) progressively recruits a Pontin/Reptin complex to open the chromatin conformation at E2f (显示 E2F1 ELISA试剂盒) target genes and amplifies the E2f (显示 E2F1 ELISA试剂盒) transcriptional response.
Reptin plays a key role in maintaining the pluripotency of embryonic stem cells and in establishing the pluripotency during reprogramming of somatic cells by regulation of Oct4 (显示 POU5F1 ELISA试剂盒)-mediated gene regulation
Gata3 (显示 GATA3 ELISA试剂盒)/Ruvbl2 complex regulates T helper 2 cell proliferation via repression of Cdkn2c (显示 CDKN2C ELISA试剂盒) expression.
We demonstrate that leukemogenic activity of MLL (显示 MLL ELISA试剂盒)-AF9 (显示 MLLT3 ELISA试剂盒) requires RUVBL2 (RuvB-like 2), an AAA (显示 AAAS ELISA试剂盒)+ ATPase (显示 DNAH8 ELISA试剂盒) family member that functions in a wide range of cellular processes, including chromatin remodeling and transcriptional regulation.
A forward genetic screen reveals roles for Nfkbid, Zeb1 (显示 ZEB1 ELISA试剂盒), and Ruvbl2 in humoral immunity.
Ectopic expression of RUVBL2 decreases the levels of ARF, whereas knockdown of RUVBL2 results in a marked increase in ARF levels. In addition, RUVBL2 down-regulates the levels of p53 in an ARF-dependent manner.
Reptin, a chromatin-remodeling factor (显示 ASH1L ELISA试剂盒), is methylated at lysine 67 in hypoxic conditions by the methyltransferase G9a (显示 EHMT2 ELISA试剂盒).
RuvBl2, which encodes an ATP-dependent DNA helicase, is specifically detected in the spermatocytes and spermatids of the adult testis as well as in primordial germ cells.
RUVBL2 plays an important role in insulin-stimulated GLUT4 translocation through its interaction with AS160
This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this gene product has both ATPase and DNA helicase activities. This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation.
RuvB-like protein 2
, RuvB-like 2
, RuvB-like 2 (E. coli)
, ruvB-like 2-like
, ruvb-like 2
, ruvB-like 2
, 48 kDa TATA box-binding protein-interacting protein
, 48 kDa TBP-interacting protein
, 51 kDa erythrocyte cytosolic protein
, INO80 complex subunit J
, RuvB (E coli homolog)-like 2
, TIP60-associated protein 54-beta
, erythrocyte cytosolic protein, 51-KD
, repressing pontin 52
, reptin52 protein