anti-H2A Histone Family, Member X (H2AFX) 抗体产品概述

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anti-H2A Histone Family, Member X 抗体 (H2AFX)
在www.antibodies-online.cn可供344 H2A Histone Family, Member X (H2AFX) 抗体的32不同的供货商。 再加上,我们可以发H2A Histone Family, Member X 试剂盒 (19)H2A Histone Family, Member X 蛋白 (9)和数多这个蛋白质的别的产品。 总共385 H2A Histone Family, Member X产品已列进来了。
别名:
AW228881, gammaH2ax, h2a, h2a.x, h2a/x, h2afx, h2ax, Hist5-2ax, RGD1566119, zgc:56329
列出全部抗体 基因 基因ID UniProt
H2AFX 3014 P16104
H2AFX 15270 P27661
H2AFX 500987  

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引用最多的anti-H2A Histone Family, Member X 抗体

  1. Human Polyclonal H2AFX Primary Antibody for ICC, IF - ABIN151847 : Masutomi, Possemato, Wong, Currier, Tothova, Manola, Ganesan, Lansdorp, Collins, Hahn: The telomerase reverse transcriptase regulates chromatin state and DNA damage responses. in Proceedings of the National Academy of Sciences of the United States of America 2005 (PubMed)
    Show all 10 references for 151847

  2. Human Monoclonal H2AFX Primary Antibody for WB - ABIN1882251 : Park, Chan, Park, Oettinger, Kwon: DNA-PK is activated by nucleosomes and phosphorylates H2AX within the nucleosomes in an acetylation-dependent manner. in Nucleic acids research 2003 (PubMed)
    Show all 5 references for 1882251

  3. Human Monoclonal H2AFX Primary Antibody for BI, WB - ABIN967669 : Burma, Chen, Murphy, Kurimasa, Chen: ATM phosphorylates histone H2AX in response to DNA double-strand breaks. in The Journal of biological chemistry 2001 (PubMed)
    Show all 5 references for 967669

  4. Human Monoclonal H2AFX Primary Antibody for WB - ABIN1882250 : Stiff, ODriscoll, Rief, Iwabuchi, Löbrich, Jeggo: ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation. in Cancer research 2004 (PubMed)
    Show all 5 references for 1882250

  5. Human Polyclonal H2AFX Primary Antibody for ICC, IF - ABIN2668328 : Velichko, Petrova, Kantidze, Razin: Dual effect of heat shock on DNA replication and genome integrity. in Molecular biology of the cell 2012 (PubMed)
    Show all 3 references for 2668328

  6. Human Polyclonal H2AFX Primary Antibody for IHC (p), WB - ABIN657639 : Jiang, Xu, Price: Acetylation of H2AX on lysine 36 plays a key role in the DNA double-strand break repair pathway. in FEBS letters 2010 (PubMed)
    Show all 3 references for 657639

  7. Cow (Bovine) Polyclonal H2AFX Primary Antibody for WB - ABIN2787619 : Scherthan, Hieber, Braselmann, Meineke, Zitzelsberger: Accumulation of DSBs in gamma-H2AX domains fuel chromosomal aberrations. in Biochemical and biophysical research communications 2008 (PubMed)
    Show all 2 references for 2787619

  8. Human Polyclonal H2AFX Primary Antibody for IF (p), IHC (p) - ABIN742538 : Shi, Yang, Mao, Wu, Ren, Yang, Yin, Wei, Li, Wang: Nutlin-3-induced redistribution of chromatin-bound IFI16 in human hepatocellular carcinoma cells in vitro is associated with p53 activation. in Acta pharmacologica Sinica 2015 (PubMed)
    Show all 2 references for 742538

  9. Human Polyclonal H2AFX Primary Antibody for IHC, ELISA - ABIN1532893 : Tyagi, Singh, Agarwal, Siriwardana, Sclafani, Agarwal: Resveratrol causes Cdc2-tyr15 phosphorylation via ATM/ATR-Chk1/2-Cdc25C pathway as a central mechanism for S phase arrest in human ovarian carcinoma Ovcar-3 cells. in Carcinogenesis 2005 (PubMed)

更多抗H2A Histone Family, Member X的相互作用对抗体

Human H2A Histone Family, Member X (H2AFX) interaction partners

  1. Cyclin F (显示 CCNF 抗体)-mediated degradation of SLBP (显示 SLBP 抗体) limits H2A.X accumulation and apoptosis upon genotoxic stress in G2 cell cycle checkpoint.

  2. study demonstrates that the individual and combined expression patterns of the DDR (显示 DDR1 抗体) molecules PARP1 (显示 PARP1 抗体), gammaH2AX, BRCA1, and BRCA2 (显示 BRCA2 抗体) could be predictive of the prognosis of STS (显示 STS 抗体) patients and suggests that controlling the activity of these DDR (显示 DDR1 抗体) molecules could be employed in new therapeutic stratagems for the treatment of STS (显示 STS 抗体)

  3. Further analysis suggested that H2AX, a PARP-1 (显示 PARP1 抗体) protein interaction partner, was coordinated with PARP-1 (显示 PARP1 抗体) in hepatocellular carcinoma tumorigenesis. Overall, some new characteristics of PARP-1 (显示 PARP1 抗体) expression were noted in the Zhuang population. PARP-1 (显示 PARP1 抗体) is a novel promising diagnostic marker for hepatocellular carcinoma in the Southern Chinese Zhuang population

  4. we found that gamma-H2AX foci at chromosome boundaries after carbon-ion irradiation contain DNA double strand breaks undergoing DNA-end resection, which promotes repair utilizing microhomology mediated end-joining during translocation.

  5. this study demonstrates an early DDR (显示 DDR1 抗体) defect of attenuated gammaH2AX signals in G0/G1 phase HGPS (显示 Zmpste24 抗体) cells and provides a plausible connection between H3K9me3 loss and DDR (显示 DDR1 抗体) deficiency.

  6. Data indicate an important role for histone H2A.X (H2AX) Tyr39 phosphorylation in gamma-H2A.X formation and cancer progression.

  7. we suggest that the XAB2 (显示 XAB2 抗体) complex mediates DNA damage response events important for the end resection step of homologous recombination , and speculate that its adjacent-localization relative to double-strand break marked by gH2AX is important for this function

  8. the epithelial-mesenchymal transition-related transcription factor Twist1 (显示 TWIST1 抗体) cooperates with Slug (显示 SNAI2 抗体) to regulate EMT (显示 ITK 抗体) upon H2A.X Loss.

  9. Upon DNA damage, an increase in the levels of chromatin bound motor protein nuclear myosin 1 (NM1 (显示 MYO1C 抗体)) ensues, which appears to be functionally linked to Upsilon-H2AX signaling.

  10. TRAF6 (显示 TRAF6 抗体) and H2AX overexpression and gammaH2AX-mediated HIF1alpha (显示 HIF1A 抗体) enrichment in the nucleus of cancer cells lead to overactivation of HIF1alpha (显示 HIF1A 抗体)-driven tumorigenesis, glycolysis and metastasis.

Mouse (Murine) H2A Histone Family, Member X (H2AFX) interaction partners

  1. The authors observe that persistent accumulation of reactive oxygen species, due to a deficient JunD-/Nrf2-antioxidant response, reduces H2AX protein levels. This effect is mediated by an enhanced interaction of H2AX with the E3 ubiquitin ligase RNF168, which is associated with H2AX poly-ubiquitination and promotes its degradation by the proteasome.

  2. TRAF6 (显示 TRAF6 抗体) and H2AX overexpression and gammaH2AX-mediated HIF1alpha (显示 HIF1A 抗体) enrichment in the nucleus of cancer cells lead to overactivation of HIF1alpha (显示 HIF1A 抗体)-driven tumorigenesis, glycolysis and metastasis.

  3. The findings highlight specific non-overlapping functions of PARP1 (显示 PARP1 抗体) and PARP2 (显示 PARP2 抗体) at H2AX-deficient chromatin during replicative phases of the cell cycle and uncover a unique requirement for PARP1 (显示 PARP1 抗体) in nonhomologous end-joining-deficient cells.

  4. Unlike directly induced DSBs, secondary DSBs were not efficiently repaired, although Rad51 (显示 RAD51 抗体) and 53BP1 (显示 TP53BP1 抗体) were recruited to these sites. H2AX was dramatically stabilized in response to DSBs directly caused by gamma-rays, enabling gammaH2AX foci formation and DSB repair, whereas H2AX was barely stabilized in response to secondary DSBs, in which gammaH2AX foci were small and DSBs were not efficiently repaired

  5. this study shows that T cells and thyrocytes in a mouse model of thyrocyte hyperplasia has foci of phosphorylated histone protein H2A.X, indicative of cellular senescence

  6. The role of H2AX phosphorylation and H3K56 acetylation on normal stem cell response to radiation

  7. H2AX knockout mice showed cell-autonomous anaemia and erythroid dysplasia, mimicking dyserythropoiesis in MDS (显示 MECOM 抗体).

  8. These data suggest a role for FoxO3a in the maintenance of genome integrity in response to DNA damage that is mediated by H2AX via yet unknown mechanisms.

  9. overexpression of TIPRL promotes phosphorylation of H2AX, and increases gamma-H2AX positive foci in response to DNA damage, whereas knockdown of TIPRL inhibits gamma-H2AX phosphorylation

  10. link gamma-H2AX to transcription, assigning a new function for this DNA damage marker

Xenopus laevis H2A Histone Family, Member X (H2AFX) interaction partners

  1. These findings suggest a dimerize-then-rearrange model for H2A-H2B dimers.

  2. Findings reveal that XH2AX has a specific role in anterior neural formation of Xenopus, which is mediated through phosphorylation of XH2AX at Thr (显示 TRH 抗体)(16) by Chk1 (显示 CHEK1 抗体).

Cow (Bovine) H2A Histone Family, Member X (H2AFX) interaction partners

  1. H2Ax phosphorylated protein was detected in in parthenogenetically activated, in vitro fertilized and cloned bovine embryos.

H2A Histone Family, Member X (H2AFX) 抗原简介

Antigen Summary

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif.

Alternative names and synonyms associated with H2A Histone Family, Member X (H2AFX)

  • H2A histone family, member X (H2AFX) 抗体
  • H2A histone family, member X (H2afx) 抗体
  • H2A histone family, member X (h2afx) 抗体
  • histone cluster 1, H2ah (HIST1H2AH) 抗体
  • histone cluster 2, H2ab (hist2h2ab) 抗体
  • histone H2A.x-like (LOC100522201) 抗体
  • histone H2A.x-like (LOC100720536) 抗体
  • AW228881 抗体
  • gammaH2ax 抗体
  • h2a 抗体
  • h2a.x 抗体
  • h2a/x 抗体
  • h2afx 抗体
  • h2ax 抗体
  • Hist5-2ax 抗体
  • RGD1566119 抗体
  • zgc:56329 抗体

Protein level used designations for H2AFX

H2AX histone , histone H2A.x , H2a/x , histone 5 protein 2ax , H2A.X , histone H2A type 1

GENE ID SPECIES
3014 Homo sapiens
15270 Mus musculus
394048 Danio rerio
734746 Xenopus laevis
531733 Bos taurus
500987 Rattus norvegicus
418708 Gallus gallus
444528 Xenopus laevis
100522201 Sus scrofa
100720536 Cavia porcellus
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