anti-PKB (PKB) 抗体产品概述

Full name:
anti-Protein Kinase B 抗体 (PKB)
在www.antibodies-online.cn可供8 Protein Kinase B (PKB) 抗体的5不同的供货商。 再加上,我们可以发PKB 试剂盒 (24)和数多这个蛋白质的别的产品。 总共32 PKB产品已列进来了。
别名:
AKT, CADTK, CAKB, FADK2, FAK2, PKB, PKB/Akt, PKBalpha, PTK, PYK2, Rac, RAFTK

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引用最多的anti-PKB 抗体

  1. Mouse (Murine) Polyclonal PKB Primary Antibody for IHC, WB - ABIN350718 : Anai, Shojima, Katagiri, Ogihara, Sakoda, Onishi, Ono, Fujishiro, Fukushima, Horike, Viana, Kikuchi, Noguchi, Takahashi, Takata, Oka, Uchijima, Kurihara, Asano: A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis. in The Journal of biological chemistry 2005 (PubMed)
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更多抗PKB的相互作用对抗体

Human Protein Kinase B (PKB) interaction partners

  1. Our findings suggest that Pyk2 (显示 PTK2B 抗体) plays an important role in the coordination of stabilization of beta-catenin (显示 CTNNB1 抗体) in the crosstalk between Wnt (显示 WNT2 抗体)/beta-catenin (显示 CTNNB1 抗体) and Wnt (显示 WNT2 抗体)/Ca(2 (显示 CA2 抗体)+) signaling pathways upon Wnt3a (显示 WNT3A 抗体) stimulation in differentiating hNPCs.

  2. STIM1 (显示 STIM1 抗体)-induced Ca(2 (显示 CA2 抗体)+) signaling activates Pyk2 (显示 PTK2B 抗体) to inhibit the interaction of VE-PTP (显示 PTPRB 抗体) and VE-cadherin (显示 CDH5 抗体) and hence increase endothelial permeability.

  3. Ascites and CCL18 (显示 CCL18 抗体) stimulate the phosphorylation and expression of Pyk2 (显示 PTK2B 抗体), which positively regulates ascites-induced ovarian cancer cell migration.

  4. We demonstrated trophoblast cytoprotection by intervention with supraphysiological concentrations of relaxin, a process in part mediated through the PI3-kinase (显示 PIK3CA 抗体)-Akt/PKB (显示 AKT1 抗体) cell survival pathway. These results provide further rationale for clinical investigation of relaxin as a potential therapeutic in preeclampsia.

  5. PTK2B polymorphism (rs28834970) could modify the risk of late-onset Alzheimer's disease (LOAD), and PTK2B polymorphism (rs28834970) and APOE may interact to increase LOAD risk in a Han Chinese population.

  6. Studies suggest that PYK2 (显示 PTK2B 抗体) is a common downstream effector of ErbB (显示 EGFR 抗体) and IL8 (显示 IL8 抗体) receptors, and that PYK2 (显示 PTK2B 抗体) integrates their signaling pathways through a positive feedback loop to potentiate breast cancer invasion.

  7. Pyk2 (显示 PTK2B 抗体) is a key downstream signaling molecules of CCR7 (显示 CCR7 抗体) in SCCHN, which promotes SCCHN tumorigenesis and progression.

  8. Phosphoproteomic analysis identifies FAK2 (显示 PTK2B 抗体) as a potential therapeutic target for tamoxifen resistance in breast cancer.

  9. Pyk2 (显示 PTK2B 抗体)-focal adhesion targeting domain interacts with and binds to leupaxin (显示 LPXN 抗体).

  10. Src (显示 SRC 抗体) has a role in priming Pyk2 (显示 PTK2B 抗体) (but not FAK (显示 PTK2 抗体)) phosphorylation and subsequent activation downstream of integrins

Mouse (Murine) Protein Kinase B (PKB) interaction partners

  1. TSC1 (显示 TSC1 抗体)/TSC2 (显示 TSC2 抗体) complex upregulation of OPN (显示 SPP1 抗体) expression is mediated by transcription factor SOX9 (显示 SOX9 抗体) in an mTOR (显示 FRAP1 抗体)-independent manner. Moreover, ablation of OPN (显示 SPP1 抗体) by deficient TSC1 (显示 TSC1 抗体)/TSC2 (显示 TSC2 抗体) complex contributed to inactivation of AKT (显示 AKT1 抗体) in TSC (显示 SLC12A3 抗体) cells

  2. Our results suggest that increasing Akt (显示 AKT1 抗体)/ NF-kappaB (显示 NFKB1 抗体) is a crucial mediator of skin aging, which can increase the susceptibility of cell transformation.

  3. findings highlight a pivotal link between an epigenetic regulator, WHSC1, and key intracellular signaling molecules, AKT, RICTOR, and Rac1, to drive prostate cancer metastasis.

  4. Studies indicate that the Pten (显示 PTEN 抗体)+/- genotype displayed neoplasia in multiple organs, including the endometrium and that the Pten (显示 PTEN 抗体) is a key regulatory player in the PI3K/PTEN (显示 PTEN 抗体)/AKT (显示 AKT1 抗体) pathway.

  5. a simple, linear, four-compartment ordinary differential equation (ODE) model of Akt (显示 AKT1 抗体) activation that tracks both the biochemical state and the physical location of Akt (显示 AKT1 抗体), is reported.

  6. Psgl-1 (显示 SELPLG 抗体) deficiency accelerates bleomycin-induced lung fibrosis and inflammation in mice through activating the PI3K/AKT (显示 AKT1 抗体) axis.

  7. Data show that docetaxel, rapamycin and tanespimycin multi-drug loaded micelles targeted against HSP90 (显示 HSP90 抗体) and the PI3K/AKT (显示 AKT1 抗体)/mTOR (显示 FRAP1 抗体) pathway in prostate cancer.

  8. Furthermore, Leishmania RNA virus 1-induced TLR-3 (显示 TLR3 抗体) activation promoted parasite persistence by enhancing macrophage survival through Akt (显示 AKT1 抗体) activation in a manner partially dependent on miR (显示 MLXIP 抗体)-155.

  9. Collectively, these findings showed that SA suppressed mammary gland development of pubertal mice, which was coincident with the SA-inhibited HC11 (显示 CCL2 抗体) proliferation, and was associated with inhibition of PI3K/Akt (显示 AKT1 抗体) signaling pathway through activation of GPR120 (显示 O3FAR1 抗体).

  10. Findings suggest that atorvastatin attenuates diabetes-associated renal injury by reducing reactive oxygen species (ROS (显示 ROS1 抗体)) generation, RhoA (显示 RHOA 抗体) activity and normalizing Akt (显示 AKT1 抗体)/GSK3beta (显示 GSK3b 抗体) signaling pathways.

Pig (Porcine) Protein Kinase B (PKB) interaction partners

  1. These results indicate glycine enhances muscle protein mass under an inflammatory condition. The beneficial roles of glycine on the muscle are closely associated with maintaining Akt (显示 AKT1 抗体)-mTOR (显示 FRAP1 抗体)-FOXO1 (显示 FOXO1 抗体) signaling and suppressing the activation of TLR4 (显示 TLR4 抗体) and/or NOD2 (显示 NOD2 抗体) signaling pathways.

  2. Data show that homocysteine (Hcy) can ameliorate the endothelium-independent hypoxic coronary vasoconstriction, in which the inhibition of PI3K/Akt (显示 AKT1 抗体) signaling pathway may be involved.

  3. In pigs, lactose synthesis was significantly elevated with the increase of milk production and AKT1 (显示 AKT1 抗体) could positively regulate lactose synthesis.

  4. In conclusion, our observations reveal that PRRSV triggers the activation of FAK-PI3K-AKT-Rac1 signaling pathway to facilitate its entry into cells.

  5. Host PI3K and Akt1 (显示 AKT1 抗体) play a role in viral gene expression, leading to an increase in porcine reproductive and respiratory syndrome virus replication.

  6. Activity of AKT (显示 AKT1 抗体) is not essential for induction of germinal vesicle breakdown in porcine oocytes but plays a substantial role during progression of meiosis to MI/MII-stage.

  7. IL-4 induced activation of Akt/SREBP-1/lipid biosynthesis in EC, resulting in protection against membrane attack complex and melittin, in association with mitochondrial protection.

  8. findings show that megalin (显示 LRP2 抗体) is the sensor that determines whether cells will be protected or injured by albumin (显示 ALB 抗体); it binds protein kinase B (PKB (显示 AKT1 抗体)) in a D-3-phosphorylated phospholipid-insensitive manner, anchoring PKB (显示 AKT1 抗体) in the luminal plasma membrane [

  9. protein kinase B (PKB/Akt (显示 AKT1 抗体))was localized in the granulosa cells of primordial follicles and in the basal layers of the granulosa cells of preantral and antral follicles, but were not localized in atretic follicles and corpora lutea

  10. Akt (显示 AKT1 抗体) signaling in porcine patellofemoral joint cartilage is dependent upon frequency of loading, cartilage zone, and the time interval between loading and cartilage harvest.

Goat Protein Kinase B (PKB) interaction partners

  1. Exogenous AKT (显示 AKT1 抗体) was transcribed, and AKT (显示 AKT1 抗体) was overexpressed, inducing the phosphorylation of p70S6K (显示 RPS6KB1 抗体) (Thr389) and 4E-BP1 (显示 EIF4EBP1 抗体) (Thr37/46) in goat fetal fibroblasts.

Cow (Bovine) Protein Kinase B (PKB) interaction partners

  1. These results demonstrate that activation of AKT (显示 AKT1 抗体) is required for gonadotropin regulation of CTNNB1 (显示 CTNNB1 抗体) accumulation and subsequent ovarian E2 production.

  2. Caveolin-1 (显示 CAV1 抗体) scaffolding domain residue phenylalanine 92 modulates Akt (显示 AKT1 抗体) signaling

  3. TG2 (显示 TGM2 抗体) contributes to 5-hydroxytryptamine-induced distal pulmonary artery smooth muscle cell proliferation via promotion of AKT (显示 AKT1 抗体) signaling, likely via its serotonylation.

  4. results suggest that PI3K-Akt (显示 AKT1 抗体) activity is important for the internalization of S. aureus and phosphorylation of GSK-3alpha, GSK-3beta (显示 GSK3b 抗体), and NF-kappaB (显示 NFKB1 抗体).

  5. The current study was designed to determine mechanisms underlying 20-hydroxyeicosatetraenoic acid -stimulated nitric oxide (NO) release, and particularly the role of NADPH oxidase (显示 NOX1 抗体), reactive oxygen species, and PI3-kinase (显示 PIK3CA 抗体) in stimulated NO release.

  6. PI3K/Akt (显示 AKT1 抗体) and p53 (显示 TP53 抗体) are redox-regulated in bovine aortic endothelial cells exposed to hydrogen peroxide

  7. Thus our data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt (显示 AKT1 抗体), mTOR (显示 FRAP1 抗体), p70S6K (显示 RPS6KB1 抗体), and ERK1/2 (显示 MAPK1/3 抗体).

  8. Gab1 (显示 GAB1 抗体) tyrosine phosphorylation is stimulated by flow shear stress to mediate protein kinase B (显示 AKT1 抗体) and endothelial nitric-oxide synthase (显示 NOS3 抗体) activation in endothelial cells

  9. Losartan metabolite stimulates eNOS (显示 NOS3 抗体) phosphorylation and suppresses tumor necrosis factor alpha (显示 TNF 抗体)-induced endothelial cell apoptosis by activating AKT1 (显示 AKT1 抗体).

  10. prostaglandin F2alpha phosphorylates TSC2 (显示 TSC2 抗体) and activates mTOR (显示 FRAP1 抗体) and ribosomal protein S6 (显示 RPS6 抗体) kinase (显示 RPS6KB1 抗体) signaling in an AKT (显示 AKT1 抗体)-independent manner

PKB 抗原简介

Antigen Summary

This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.

Alternative names and synonyms associated with PKB

  • protein tyrosine kinase 2 beta (PTK2B) 抗体
  • thymoma viral proto-oncogene 1 (Akt1) 抗体
  • v-akt murine thymoma viral oncogene homolog 1 (Akt1) 抗体
  • v-akt murine thymoma viral oncogene homolog 1 (AKT1) 抗体
  • v-akt murine thymoma viral oncogene homolog 2 (AKT2) 抗体
  • AKT 抗体
  • CADTK 抗体
  • CAKB 抗体
  • FADK2 抗体
  • FAK2 抗体
  • PKB 抗体
  • PKB/Akt 抗体
  • PKBalpha 抗体
  • PTK 抗体
  • PYK2 抗体
  • Rac 抗体
  • RAFTK 抗体

Protein level used designations for anti-Protein Kinase B (PKB) 抗体

CAK-beta , FADK 2 , PTK2B protein tyrosine kinase 2 beta , calcium-dependent tyrosine kinase , calcium-regulated non-receptor proline-rich tyrosine kinase , cell adhesion kinase beta , focal adhesion kinase 2 , proline-rich tyrosine kinase 2 , protein kinase B , protein-tyrosine kinase 2-beta , related adhesion focal tyrosine kinase , AKT1 kinase , PKB alpha , RAC-PK-alpha , RAC-alpha serine/threonine-protein kinase , protein kinase B alpha , protein kinase B-alpha , proto-oncogene c-AKT , related to A and C kinases , RAC protein kinase alpha RAC-PK alpha , murine thymoma viral (v-akt) oncogene homolog 1 , thymoma viral proto-oncogene 1 , v-akt murine thymoma viral oncogene-like 1 , v-akt murine thymoma viral oncogene-like protein 1 , RAC-beta serine/threonine-protein kinase

GENE ID SPECIES
2185 Homo sapiens
11651 Mus musculus
24185 Rattus norvegicus
100126861 Sus scrofa
100860904 Capra hircus
280991 Bos taurus
100294652 Ovis aries
449021 Canis lupus familiaris
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