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Our results provide new insight into the effect of ITK and suboptimal T-cell receptor signaling on CD8 (显示 CD8A ELISA试剂盒)(+) T cell function, and how these may contribute to phenotypes associated with ITK deficiency
Data suggest that the pleckstrin homology domain of Itk functions as a phospholipid bilayer recognition site that localizes Itk to membrane via phosphatidylinositol 3,4,5-trisphosphate (PIP3) binding; this specific binding inhibits the phospho-transfer reaction via an allosteric mechanism.
pharmacological inhibition of ITK resulted in T cell hyperplasia and the increased production of TH2-type cytokines.
ITK and BTK (显示 BTK ELISA试剂盒) regulate thermal homeostasis during septic response through mast cell function in mice.
Taken together, these data indicate that ITK plus RLK (显示 TXK ELISA试剂盒) inhibition may have therapeutic potential in Th1 (显示 HAND1 ELISA试剂盒)-mediated inflammatory diseases.
This work has important implications for understanding the role of Itk signaling in the development versus function of iNKT cells, Th1 (显示 HAND1 ELISA试剂盒), Th2, and Th17 cells.
The kinase Itk and the adaptor TSAd change the specificity of the kinase Lck (显示 LCK ELISA试剂盒) in T cells by promoting the phosphorylation of Tyr192.
Data indicate that the interleukin-2 (显示 IL2 ELISA试剂盒) inducible tyrosine kinase (显示 TYRO3 ELISA试剂盒) K390R point mutation (Itk-KD) transgenic mice were largely protected from inflammatory symptoms in an Ovalbumin (显示 OVA ELISA试剂盒) model of airway inflammation.
The Itk pleckstrin (显示 PLEK ELISA试剂盒) homology domain binds to Calmodulin and PI(3,4,5)Pto promote efficient calcium signaling and IL-17A (显示 IL17A ELISA试剂盒) production.
Signaling by Itk promotes autoimmunity and CNS inflammation.
The data indicate that increased ITK expression could act as a disease activity marker and as a risk factor for involvement in SLE, but it still needs further study to confirm.
We conclude that ITK, formerly considered an immune cell-specific protein, is aberrantly expressed in melanoma and promotes tumor development and progression
Found that 38% and 14% of the Angioimmunoblastic T-cell lymphoma cases exhibited gains of ITK and SYK (显示 SYK ELISA试剂盒) genes, respectively.
These data indicate that PRN694 is a highly selective and potent covalent inhibitor of ITK and RLK (显示 TXK ELISA试剂盒), and its extended target residence time enables durable attenuation of effector cells in vitro and in vivo.
approach identified 18 kinase and kinase-related genes whose overexpression can substitute for EGFR (显示 EGFR ELISA试剂盒) in EGFR (显示 EGFR ELISA试剂盒)-dependent PC9 (显示 PCSK9 ELISA试剂盒) cells, and these genes include seven of nine Src (显示 SRC ELISA试剂盒) family kinase genes, FGFR1 (显示 FGFR1 ELISA试剂盒), FGFR2 (显示 FGFR2 ELISA试剂盒), ITK, NTRK1 (显示 NTRK1 ELISA试剂盒), NTRK2 (显示 NTRK2 ELISA试剂盒), MOS (显示 MOS ELISA试剂盒), MST1R (显示 MST1R ELISA试剂盒), and RAF1 (显示 RAF1 ELISA试剂盒).
ITK deficiency is a genetic cause of idiopathic CD4 (显示 CD4 ELISA试剂盒)+ T-cell lymphopenia.
Data indicate reduced T-cell activation by altered IL-2 inducible T-cell kinase (ITK) expression in vitro.
T-cell-specific human ITK-Syk (显示 SYK ELISA试剂盒) oncogene (显示 RAB1A ELISA试剂盒) in mice leads to early polyclonal T cell lymphoproliferation (显示 FAS ELISA试剂盒) with B cell expansion. It induces terminal T cell differentiation via Blimp-1 (显示 PRDM1 ELISA试剂盒), eliminating oncogene (显示 RAB1A ELISA试剂盒)-expressing cells early in development.
This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation.
, interleukin-2-inducible T cell kinase
, kinase TLK
, tyrosine-protein kinase ITK/TSK
, IL-2-inducible T cell kinase
, IL-2-inducible T-cell kinase
, homolog of mouse T-cell itk/tsk
, interleukin-2-inducible T-cell kinase
, kinase EMT
, tyrosine-protein kinase LYK