anti-Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D) 抗体产品概述

在www.antibodies-online.cn可供146 Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D) 抗体的19不同的供货商。 再加上,我们可以发Inositol Polyphosphate-5-Phosphatase, 145kDa 试剂盒 (16)Inositol Polyphosphate-5-Phosphatase, 145kDa 蛋白 (3)和数多这个蛋白质的别的产品。 总共174 Inositol Polyphosphate-5-Phosphatase, 145kDa产品已列进来了。
别名:
13.t00027, 256.t00004, AI323613, hp51CN, INPP5D, s-SHIP, SHIP, SHIP-1, SHIP1, SIP-145
列出全部抗体 基因 基因ID UniProt
INPP5D 16331 Q9ES52
INPP5D 54259 P97573
INPP5D 3635 Q92835

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更多抗Inositol Polyphosphate-5-Phosphatase, 145kDa的相互作用对抗体

Zebrafish Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D) interaction partners

Mouse (Murine) Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D) interaction partners

  1. Rictor (显示 RICTOR 抗体) positively regulates B cell receptor signaling via up-regulating Btk (显示 BTK 抗体) and down-regulating SH2-containing inositol phosphatase

  2. MiR (显示 MLXIP 抗体)-155 promotes experimental colitis by repressing SHIP-1 expression.

  3. Results are consistent with predicted/observed reduction in the Lyn-SHIP-1-PTEN-SHP-1 axis function in B cells from systemic lupus

  4. SHIP has a role in extracellular matrix accumulation via suppressing PI3K/Akt (显示 AKT1 抗体)/CTGF (显示 CTGF 抗体) signaling in diabetic kidney dise

  5. this study shows that FcgammaRIIb drives the sequential dephosphorylation system comprising SHIP1/2 and Inpp4a (显示 INPP4A 抗体), and accelerates phagosome acidification

  6. Data (including data from studies in knockout mice) suggest that up-regulation of signaling in colonic mucosa via interleukin-10 (显示 IL10 抗体)/microRNA-155/SHIP-1 (Src homology 2 domain-containing inositol-5-phosphatase) is involved in development of colitis due to dysbiosis.

  7. Our results describe a critical role for SHIP-1 in regulating the ability of dendritic cells to efficiently prime Th2-type responses.

  8. Findings indicate a role for inositol-polyphosphate 5-phosphatase SHIP-1 coupling to DC-type lectin receptor ectin-1 hemITAM in the selective control of downstream responses.

  9. miR (显示 MLXIP 抗体)-155 regulates the delicate balance between PAK1 (显示 PAK1 抗体)-mediated proliferation and apoptosis in T cells impacting lymphoid organ size and function.

  10. miR (显示 MLXIP 抗体)-155 regulation of SHIP represents a unique axis that regulates dendritic cells function in vivo.

Human Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D) interaction partners

  1. JARID1B (显示 KDM5B 抗体) directly bound to PI3K (显示 PIK3CA 抗体)/AKT (显示 AKT1 抗体) signaling inhibitor SHIP1 gene promoter and decreased SHIP1 gene expression.

  2. Study shows that SHIP1 activity is decreased in adult Crohn's disease (CD) patients either through reduced intrinsic enxymatic activity or reduced protein expression, and propose that in addition to ATG16L1 (显示 ATG16L1 抗体), SHIP1 may contribute to the risk conferred by the 2q37 CD risk locus.

  3. results indicate that FcgammaRIIB is not uniquely able to promote membrane recruitment of SHIP, but rather modulates its function via formation of distinct signaling complexes. Membrane recruitment of SHIP via Syk (显示 SYK 抗体)-dependent mechanisms may be an important factor modulating immunoreceptor signaling.

  4. SHIP has a role in extracellular matrix accumulation via suppressing PI3K (显示 PIK3CA 抗体)/Akt (显示 AKT1 抗体)/CTGF (显示 CTGF 抗体) signaling in diabetic kidney dise

  5. SHIP levels and activity are lower in intestinal tissues and peripheral blood samples from patients with Crohn's disease, resulting in induction of Il1-beta (显示 IL1B 抗体).

  6. Underexpression of SHIP1 is associated with drug resistance in acute myeloid leukemia (显示 BCL11A 抗体).

  7. ectopically expressed SHIP1 accumulates in nucleolar cavities and colocalizes with the tumor suppressor protein p53 (显示 TP53 抗体).

  8. Results show that expression of SHIP1 protein is targeted by miR (显示 MLXIP 抗体)-155 in acute myeloid leukemia (显示 BCL11A 抗体) (AML (显示 RUNX1 抗体)) suggesting it as an onco-miR (显示 MLXIP 抗体). The miR (显示 MLXIP 抗体)-155/SHIP1/PI3K (显示 PIK3CA 抗体)/AKT (显示 AKT1 抗体) signaling pathway could play an important role in the pathogenesis of AML (显示 RUNX1 抗体).

  9. Overexpression of miR (显示 MLXIP 抗体)-155 in the gouty synovial fluid mononuclear cells leads to suppress SHIP-1 levels and enhance proinflammatory cytokines.

  10. SLAMF7 (显示 SLAMF7 抗体)-triggered inhibition is mediated by a mechanism involving Src (显示 SRC 抗体) kinases, CD45 (显示 PTPRC 抗体), and SHIP-1 that is defective in MM cells

Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D) 抗原简介

Antigen Summary

This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Alternative names and synonyms associated with Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D)

  • inositol polyphosphate-5-phosphatase, 145kDa (INPP5D) 抗体
  • inositol polyphosphate-5-phosphatase, 145kDa (inpp5d) 抗体
  • inositol polyphosphate 5-phosphatase (EHI_159880) 抗体
  • inositol polyphosphate 5-phosphatase (EHI_153490) 抗体
  • phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 (inpp5d) 抗体
  • Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 (ship1) 抗体
  • inositol polyphosphate-5-phosphatase D (Inpp5d) 抗体
  • 13.t00027 抗体
  • 256.t00004 抗体
  • AI323613 抗体
  • hp51CN 抗体
  • INPP5D 抗体
  • s-SHIP 抗体
  • SHIP 抗体
  • SHIP-1 抗体
  • SHIP1 抗体
  • SIP-145 抗体

Protein level used designations for INPP5D

inositol polyphosphate-5-phosphatase, 145kDa , SH2 containing inositol phosphatase , phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 , phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1-like , SH2 domain-containing inositol 5'-phosphatase 1 , SH2 domain-containing inositol phosphatase 1 , SH2 domain-containing inositol-5'-phosphatase 1 , SHIP-1 , phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 , Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1 , SH2 containing inositol phosphotase , SH2-containing inositol phosphatase SHIP , SIP-145 , Src homology 2 domain-containing inositol-5-phosphatase , inositol polyphosphate-5-phosphatase of 145 kDa , inositol polyphosphate-5-phosphatase, 145 kDa , p150Ship , Inositol polyphosphate-5-phosphatase 145 kDa , Inositol polyphosphate-5-phosphatase, 145 kDa , signaling inositol polyphosphate 5 phosphatase SIP-145

GENE ID SPECIES
424745 Gallus gallus
470683 Pan troglodytes
507329 Bos taurus
100021361 Monodelphis domestica
100400043 Callithrix jacchus
100446045 Pongo abelii
100464150 Ailuropoda melanoleuca
559103 Danio rerio
3404260 Entamoeba histolytica HM-1:IMSS
3410671 Entamoeba histolytica HM-1:IMSS
100064896 Equus caballus
100526019 Sus scrofa
100561031 Anolis carolinensis
399051 Xenopus laevis
100380693 Salmo salar
16331 Mus musculus
54259 Rattus norvegicus
3635 Homo sapiens
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