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CBL 抗体

(Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL))
This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Mar 2012].
CBL 抗体 CBL 抗体 CBL 抗体 (ABIN968993)

CBL 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 3B12 unconjugated

CBL 抗体  (AA 736-835) CBL 抗体  (AA 736-835) CBL 抗体 (AA 736-835) (ABIN560198)

CBL 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 6D12 unconjugated

CBL 抗体  (AA 1-906) CBL 抗体  (AA 1-906) CBL 抗体 (AA 1-906) (ABIN949994)

CBL 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated

CBL 抗体 by Grade

Find CBL 抗体 with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

CBL 抗体 by 适用

Find CBL 抗体 for a variety of species such as anti-Human CBL, anti-Rat CBL, anti-Mouse CBL. The species listed below are among those available. Click on a link to go to the corresponding products.

CBL 抗体 by 应用范围

Find CBL 抗体 validated for a specific application such as WB, IF (cc), IF (p), ELISA. Some of the available applications are listed below. Click on a link to go to the corresponding products.

CBL 抗体 by 抗体来源

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CBL 抗体 by 抗原表位

Find CBL 抗体 with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.

CBL 抗体 by 克隆形成能力

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CBL 抗体 by 克隆

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CBL 抗体 by 标记

Find CBL 抗体 with a specific conjugate such as Biotin, Alexa Fluor 488, Alexa Fluor 555. The conjugates listed below are among those available. Click on a link to go to the corresponding products.

Popular CBL 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC, FACS, ICC
Validations
  • (3)
  • (7)
Cat. No. ABIN968993
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IP
Validations
  • (5)
Cat. No. ABIN560198
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IP
Validations
  • (4)
Cat. No. ABIN949994
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, PLA
Validations
  • (4)
Cat. No. ABIN514071
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC, IF, ICC
Validations
  • (4)
Cat. No. ABIN6260513
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC, IF
Validations
  • (3)
Cat. No. ABIN7150995
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC, IF
Validations
  • (3)
Cat. No. ABIN7139065
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IHC, IF
Validations
  • (3)
Cat. No. ABIN7254979
Quantity 200 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC, IF, ICC
Validations
  • (3)
Cat. No. ABIN6256785
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC
Validations
  • (3)
Cat. No. ABIN6138002
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro)
Validations
  • (2)
Cat. No. ABIN753403
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC, IF
Validations
  • (2)
Cat. No. ABIN3183701
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN533153
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN533155
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF, ICC
Validations
  • (2)
Cat. No. ABIN2855019
Quantity 100 μL
Datasheet Datasheet

Latest Publications for our CBL 抗体

Sproul, Xu, Wilhelm, Gire, Greene: "Cbl negatively regulates JNK activation and cell death." in: Cell research, Vol. 19, Issue 8, pp. 950-61, (2009) (PubMed).

Sanada, Suzuki, Shih, Otsu, Kato, Yamazaki, Tamura, Honda, Sakata-Yanagimoto, Kumano, Oda, Yamagata, Takita, Gotoh, Nakazaki, Kawamata, Onodera, Nobuyoshi, Hayashi, Harada, Kurokawa, Chiba, Mori et al.: "Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms. ..." in: Nature, Vol. 460, Issue 7257, pp. 904-8, (2009) (PubMed).

Loh, Sakai, Flotho, Kang, Fliegauf, Archambeault, Mullighan, Chen, Bergstraesser, Bueso-Ramos, Emanuel, Hasle, Issa, van den Heuvel-Eibrink, Locatelli, Stary, Trebo, Wlodarski, Zecca, Shannon et al.: "Mutations in CBL occur frequently in juvenile myelomonocytic leukemia. ..." in: Blood, Vol. 114, Issue 9, pp. 1859-63, (2009) (PubMed).

Swaminathan, Tsygankov: "The Cbl family proteins: ring leaders in regulation of cell signaling." in: Journal of cellular physiology, Vol. 209, Issue 1, pp. 21-43, (2006) (PubMed).

Thien, Langdon: "c-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signalling responses." in: The Biochemical journal, Vol. 391, Issue Pt 2, pp. 153-66, (2005) (PubMed).

Jiang, Huang, Marusyk, Sorkin: "Grb2 regulates internalization of EGF receptors through clathrin-coated pits." in: Molecular biology of the cell, Vol. 14, Issue 3, pp. 858-70, (2003) (PubMed).

Miura-Shimura, Duan, Rao, Reddi, Shimura, Rottapel, Druker, Tsygankov, Band, Band: "Cbl-mediated ubiquitinylation and negative regulation of Vav." in: The Journal of biological chemistry, Vol. 278, Issue 40, pp. 38495-504, (2003) (PubMed).

Thien, Langdon: "Cbl: many adaptations to regulate protein tyrosine kinases." in: Nature reviews. Molecular cell biology, Vol. 2, Issue 4, pp. 294-307, (2001) (PubMed).

Tsygankov, Teckchandani, Feshchenko, Swaminathan: "Beyond the RING: CBL proteins as multivalent adapters." in: Oncogene, Vol. 20, Issue 44, pp. 6382-402, (2001) (PubMed).

Burke, Schooler, Wiley: "Regulation of epidermal growth factor receptor signaling by endocytosis and intracellular trafficking." in: Molecular biology of the cell, Vol. 12, Issue 6, pp. 1897-910, (2001) (PubMed).

Aliases for CBL 抗体

Casitas B-lineage lymphoma (Cbl) 抗体
Cbl proto-oncogene (CBL) 抗体
Cbl proto-oncogene (Cbl) 抗体
4732447J05Rik 抗体
c-Cbl 抗体
C-CBL 抗体
c-cbl-like 抗体
cbl 抗体
Cbl-2 抗体
CBL2 抗体
FRA11B 抗体
NSLL 抗体
RGD1561386 抗体
RNF55 抗体
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