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CARMA1 may be aberrantly upregulated in T-ALL, leading to disease progression and migration of leukemic cells to the CNS
findings indicate that a single hypomorphic mutation in CARD11 can cause potentially correctable cellular defects that lead to atopic dermatitis
NF-kappaB (显示 NFKB1 ELISA试剂盒) and beta-catenin (显示 CTNNB1 ELISA试剂盒) signaling by gain-of-function mutations in CARMA1 augments WNT (显示 WNT2 ELISA试剂盒) stimulation and is required for regulating the expression of distinct NF-kappaB (显示 NFKB1 ELISA试剂盒) target genes to trigger cell-intrinsic and extrinsic processes that promote DLBCL lymphomagenesis
CARD11 mutations are rare in patients with CD5 (显示 CD5 ELISA试剂盒)+ DLBCL.
results define molecular determinants that control the production of Lin(Ub)n-Bcl10 (显示 BCL10 ELISA试剂盒), an important signaling intermediate in TCR and oncogenic CARD11 signaling.
We evaluated the relationship between rs4722404 polymorphism in the CARD11 gene, and the risk and clinical features of psoriasis vulgaris in a southern Chinese Han cohort.We identified no association between the SNP and risk of psoriasis vulgaris.
single amino acid oncogenic CARD11 mutations can perturb or bypass the action of redundant inhibitory REs to achieve the level of hyperactive CARD11 signaling required to support lymphoma growth.
Cooperative Control of Caspase Recruitment Domain-containing Protein 11 (CARD11) Signaling by an Unusual Array of Redundant Repressive Elements.
CARMA1- and MyD88 (显示 MYD88 ELISA试剂盒)-dependent activation of Jun (显示 JUN ELISA试剂盒)/ATF-type AP-1 (显示 FOSB ELISA试剂盒) complexes is a hallmark of ABC (显示 ABCB6 ELISA试剂盒) diffuse large B-cell lymphomas.
Data show that caspase recruitment domain-containing protein 11/B-cell CLL/lymphoma 10 (显示 BCL10 ELISA试剂盒)/mucosa-associated lymphoid tissue lymphoma translocation gene 1 (显示 MALT1 ELISA试剂盒) signaling drives lymphoproliferation (显示 FAS ELISA试剂盒) through NF-kappa B (显示 NFKB1 ELISA试剂盒) and c-Jun N-terminal kinase activation.
synergistic activity of Card11 mutant and Bcl6 (显示 BCL6 ELISA试剂盒) in the development of diffuse large B-cell lymphoma in a mouse model
CARMA1 clustering through SH3-GUK domain interactions is required for its activation of NF-kappaB (显示 NFKB1 ELISA试剂盒) signalling
data suggest that Carma1 and MALT1 play previously unappreciated roles in the activation of mTOR signaling in T cells after engagement of the TCR.
CARMA1 CARD shows the first homo-dimeric structure of CARD formed by a disulfide bond and reveals a possible biologically important homo-dimerization mechanism
Data indicate that caspase recruitment domain-containing protein 11 (CARD11) is involved in the pathogenesis of collagen-induced arthritis (CIA (显示 NCOA5 ELISA试剂盒)) by formation of the CARD11/Bcl10 (显示 BCL10 ELISA试剂盒) complex and enhancement of the Th17 cell response.
Genetic approach demonstrates a critical role for the CARD function of CARMA1 in Treg cell development in vivo.
both CARMA1 CARD and BCL10 CARD easily self-oligomerized under physiological conditions.
Findings show that regulation of CARD11 signaling is a critical switch governing the decision between death and proliferation in antigen-stimulated mature B cells.
TCR/CARMA1/NF-kappaB (显示 NFKB1 ELISA试剂盒) controls completion of Th17 differentiation.
These studies provide molecular insight into the assembly of CARMA1 and BCL10.
The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10.
CARD-containing MAGUK protein 1
, bcl10-interacting maguk protein 3
, carma 1
, caspase recruitment domain-containing protein 11
, caspase recruitment domain family, member 11
, caspase recruitment domain-containing protein 11-like