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Aurora A (显示 AURKA ELISA试剂盒) and B kinases directly phosphorylate Lgl to promote its mitotic relocalization.
Regulation of Polo (显示 PLK1 ELISA试剂盒) by Aurora B and Map205 is required for cytokinesis.
We propose that mutual inhibitions between Aurora B a (显示 CDK1 ELISA试剂盒)nd Cyclin B regulate the duration of abscission and thereby the number of sister cells in each cyst.
Aurora B kinase activity is not required during contractile ring ingression, providing insight into the mechanism of cytokinesis.
Aurora B interacts with and requires the Cdc37 (显示 CDC37 ELISA试剂盒)/Hsp90 (显示 HSP90 ELISA试剂盒) complex for its stability.
INCENP (显示 INCENP ELISA试剂盒) binds to the cohesion protector protein (显示 PRDX2 ELISA试剂盒) MEI-S332, which is also an excellent in vitro substrate for Aurora B kinase.
Data show that aurora-B regulates end-on conversion in human cells and indicate a late role for SPAG5 (显示 SPAG5 ELISA试剂盒) protein (Astrin (显示 SPAG5 ELISA试剂盒))-SKAP (显示 KNSTRN ELISA试剂盒) complex in the end-on conversion process.
The results of experiment indicated that specific knockdown of Aurora kinase B led to prostate carcinoma cells apoptosis and inhibited tumor growth.
decrease in Aurora B results in diminished binding of the chromokinesin Kif4A to chromosome arms.
Aurora B kinase interacts with and phosphorylates Sgo1 (显示 SGOL1 ELISA试剂盒). Aurora B-mediated phosphorylation of Sgo1 (显示 SGOL1 ELISA试剂盒) regulates the distribution of Sgo1 (显示 SGOL1 ELISA试剂盒) between centromeres and chromosome arms.
AURKC (显示 AURKC ELISA试剂盒) rs758099 TT and (CC + CT) genotypes were positively associated with increased intestinal type gastric cancer (GC)risk, but not with an increased diffuse type GC risk. Based on these results, we can conclude that AURKA (显示 AURKA ELISA试剂盒) rs1047972 and AURKC (显示 AURKC ELISA试剂盒) rs758099 polymorphisms could affect the risk of GC development.
Aurora-C (显示 AURKC ELISA试剂盒) interactions with members of the Chromosome Passenger Complex (CPC), Survivin (显示 BIRC5 ELISA试剂盒) and Inner Centromere Protein (INCENP (显示 INCENP ELISA试剂盒)) in reference to known Aurora-B interactions to understand the functional significance of Aurora-C (显示 AURKC ELISA试剂盒) overexpression in human cancer cells, is reported.
Aurora kinase (显示 AURKA ELISA试剂盒) inhibitor danusertib negatively regulated AURKB/p70S6K (显示 RPS6KB1 ELISA试剂盒)/RPL15 (显示 RPL15 ELISA试剂盒) axis with the involvement of PI3K (显示 PIK3CA ELISA试剂盒)/Akt (显示 AKT1 ELISA试剂盒)/mTOR (显示 FRAP1 ELISA试剂盒), AMPK (显示 PRKAA1 ELISA试剂盒), and p38 MAPK (显示 MAPK14 ELISA试剂盒) signaling pathways, leading to the induction of apoptosis and autophagy in human leukemia cells.
The kinase activity of Aurora B on serine 31 of histone H3.3 (显示 H3F3A ELISA试剂盒) was biochemically confirmed with nucleosomal substrates in vitro.
in addition to its role in checkpoint signaling, MAD2 (显示 MAD2L1 ELISA试剂盒) ensures chromosome stability through the regulation of AURORA B.
Ska promotes Aurora B activity to limit its own microtubule and kinetochore association.
Aurkb phosphorylates Oct4 (显示 POU5F1 ELISA试剂盒)(S229) during G2/M phase, leading to the dissociation of Oct4 (显示 POU5F1 ELISA试剂盒) from chromatin, whereas PP1 (显示 PPP1CC ELISA试剂盒) binds Oct4 (显示 POU5F1 ELISA试剂盒) and dephosphorylates Oct4 (显示 POU5F1 ELISA试剂盒)(S229) during M/G1 transition, which resets Oct4 (显示 POU5F1 ELISA试剂盒)-driven transcription for pluripotency and the cell cycle.
Overexpression of Aurora B (显示 AURKC ELISA试剂盒) also results in a reduced DNA damage response and decreased levels of the p53 (显示 TP53 ELISA试剂盒) target p21(Cip1 (显示 CDKN1A ELISA试剂盒)) in vitro and in vivo.
Chromsome stability is on of the tumor-suppressive functions of ARF as well as regulation of Aurora B (显示 AURKC ELISA试剂盒) expression in tumors.
Using this mutant we show for the first time that AURKC has functions that do not overlap with AURKB. These functions include regulating localized CPC activity and regulating chromosome alignment and K-MT attachments at metaphase of meiosis I (Met I).
reduced accumulation of Aurora B (显示 AURKC ELISA试剂盒) at the inner centromere region in cells lacking Pds5B (显示 PDS5B ELISA试剂盒) impairs its error correction function, promoting chromosome mis (显示 AMH ELISA试剂盒)-segregation and aneuploidy
Aurora B (显示 AURKC ELISA试剂盒) and Ring1B (显示 RNF2 ELISA试剂盒) co-occupy active promoters in resting lymphocytes.
FBXL2 (显示 FBXL2 ELISA试剂盒) mediates Aurora B (显示 AURKC ELISA试剂盒) ubiquitination and degradation within the midbody, which is sufficient to induce mitotic arrest and apoptosis.
Inhibitions of Aurora B (显示 AURKC ELISA试剂盒) and Cyclin-dependent kinase 1 (显示 CDK1 ELISA试剂盒) activity in vertebrate cells also have opposite effects on the timing of abscission.
Aurora B (显示 AURKC ELISA试剂盒) represses p21(Cip1 (显示 CDKN1A ELISA试剂盒)), preventing delayed DNA replication, Cdk (显示 CDK4 ELISA试剂盒) inhibition and premature mitotic exit.
Calmodulin protects Aurora B (显示 AURKC ELISA试剂盒) on the midbody to regulate the fidelity of cytokinesis.
Alterations in PGRMC1 (显示 PGRMC1 ELISA试剂盒) and/or AURKB localization account in part for the increased aneuploidy and low development competence of oocytes from ovaries with reduced antral follicle counts.
AURKB associated with metaphase chromosomes.
Aurora B kinase is essential for furrow induction and maturation in the zebrafish embryo.
This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding different isoforms have been found for this gene.
, aurora B
, aurora B kinase
, dAurora B
, aurora/IPL1-related kinase 2
, serine/threonine-protein kinase 12
, serine/threonine-protein kinase aurora-B
, aurora kinase B
, serine/threonine-protein kinase 12-like
, aurora 1
, aurora kinase B-Sv1
, aurora kinase B-Sv2
, aurora- and Ipl1-like midbody-associated protein 1
, aurora-related kinase 2
, protein phosphatase 1, regulatory subunit 48
, serine/threonine kinase 12
, serine/threonine-protein kinase 5
, aurora- and IPL1-like midbody-associated protein 1
, serine/threonine kinase 5
, Serine/threonine-protein kinase 12
, cellular island
, serine/threonine kinase a
, I-kappa-B kinase 2
, I-kappa-B-kinase beta
, inhibitor of kappaB kinase beta
, inhibitor of nuclear factor kappa B kinase beta subunit
, inhibitor of nuclear factor kappa-B kinase subunit beta
, nuclear factor NF-kappa-B inhibitor kinase beta