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PIP5K1A 蛋白

(Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A))
Catalyzes the phosphorylation of phosphatidylinositol 4- phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as actin cytoskeleton organization, cell adhesion, migration and phagocytosis. Required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of RAC1 to the plasma membrane. Together with PIP5K1C is required for phagocytosis, but they regulate different types of actin remodeling at sequential steps. Promotes particle ingestion by activating WAS that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup. Together with PIP5K1B is required after stimulation of G-protein coupled receptors for stable platelet adhesion. Plays a role during calcium-induced keratinocyte differentiation. Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, diacylglycerol and inositol 1,4,5-trisphosphate that mobilize internal calcium and drive keratinocyte differentiation. Together with PIP5K1C have a role during embryogenesis. Functions also in the nucleus where acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs.
PIP5K1A Protein (AA 258-347) (GST tag) PIP5K1A Protein (AA 258-347) (GST tag) PIP5K1A Protein (AA 258-347) (GST tag) (ABIN1315137)

PIP5K1A 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA

PIP5K1A Protein (AA 1-500) (GST tag) PIP5K1A Protein (AA 1-500) (GST tag) PIP5K1A Protein (AA 1-500) (GST tag) (ABIN1315135)

PIP5K1A 宿主: 人 宿主: 小麦胚 Recombinant ELISA, WB, AP, AA

PIP5K1A Protein (AA 1-562) (His tag) PIP5K1A Protein (AA 1-562) (His tag) PIP5K1A Protein (AA 1-562) (His tag) (ABIN3094634)

Crystallography grade PIP5K1A 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, WB, Crys, SDS

PIP5K1A 蛋白 by Grade

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PIP5K1A 蛋白 by Origin

Find PIP5K1A 蛋白 for a variety of species such as anti-Human PIP5K1A, anti-Mouse PIP5K1A. The species listed below are among those available. Click on a link to go to the corresponding products.

PIP5K1A 蛋白 by Source

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PIP5K1A 蛋白 by 蛋白类型

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PIP5K1A 蛋白 by 应用范围

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PIP5K1A 蛋白 by 生物活性

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Popular PIP5K1A 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1315137
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1315135
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3094634
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3134617
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
Cat. No. ABIN5509093
Quantity 10 μg
Datasheet Datasheet

Aliases for PIP5K1A 蛋白

phosphatidylinositol-4-phosphate 5-kinase type 1 alpha (PIP5K1A) 蛋白
phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha (Pip5k1a) 蛋白
phosphatidylinositol-4-phosphate 5-kinase, type I, alpha L homeolog (pip5k1a.L) 蛋白
phosphatidylinositol-4-phosphate 5-kinase, type I, alpha (pip5k1a) 蛋白
phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha (Pip5k1a) 蛋白
phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, a (pip5k1aa) 蛋白
phosphatidylinositol-4-phosphate 5-kinase type 1 alpha (Pip5k1a) 蛋白
phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, b (pip5k1ab) 蛋白
im:7140933 蛋白
PIP5K1A 蛋白
pip5k1a 蛋白
Pip5k1b 蛋白
pip5k1b 蛋白
pip5k1c 蛋白
Pipk5a 蛋白
Pipk5b 蛋白
zgc:110576 蛋白
zgc:158838 蛋白
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