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Plexin C1 deficiency permits synaptotagmin 7-mediated macrophage mig (显示 PLXNC1 ELISA试剂盒)ration and enhances mammalian lung fibrosis
RNA knockdown of Syt-7 in human islets reduced first- and second-phase glucose-stimulated insulin (显示 INS ELISA试剂盒) secretion attributed to the reduction of exocytosis of predocked and newcomer insulin (显示 INS ELISA试剂盒) secretory granules
Data indicate that small protein sequence changes in the Ca(2 (显示 CA2 ELISA试剂盒)+)-binding loops of the C2 domains may give rise to the difference in binding kinetics between Syt-1 (显示 SYT1 ELISA试剂盒) and Syt-7 isoforms.
the results suggest that the two C2 domains of Syt7 bind independently to planar membranes, in contrast to reported interdomain cooperativity in Syt1 (显示 SYT1 ELISA试剂盒)
The membrane dissociation of SYT7 C2A domain but not SYT1 C2A domain is slowed by Na(2)SO(4) and trehalose, solutes that enhance the hydrophobic effect.
identified the conserved alternative splicing events in the spacer domain of Syt VII; also shown that Syt (显示 SS18 ELISA试剂盒) VIIa-GFP is mainly localized in the perinuclear region and tips of neurites (dense-core vesicles), and not in the plasma membrane
data demonstrate the previously unrecognized observation that PLXNC1 (显示 PLXNC1 ELISA试剂盒) deficiency permits Syt7-mediated macrophage migration and enhances mammalian lung fibrosis
At the calyx synapse that syt7-dependent asynchronous release indeed does not produce a prolonged synaptic signal after a stimulus train and does not contribute to short-term plasticity, but induces a steady-state, asynchronous postsynaptic current during stimulus trains. This steady-state postsynaptic current sustains reliable generation of postsynaptic spikes that are precisely time locked to presynaptic spikes.
results suggest that postsynaptic Syt1 (显示 SYT1 ELISA试剂盒) and Syt7 act as redundant Ca(2 (显示 CA2 ELISA试剂盒)+)-sensors for Ca(2 (显示 CA2 ELISA试剂盒)+)-dependent exocytosis of AMPA (显示 GRIA3 ELISA试剂盒) receptors during long-term potentiation, and thereby delineate a simple mechanism for the recruitment of AMPA (显示 GRIA3 ELISA试剂盒) receptors that mediates LTP (显示 SCP2 ELISA试剂盒)
Data (including data from studies in knockout mice) suggest that loss of both Syt1 (显示 SYT1 ELISA试剂盒)/Syt7 decreases capacity of readily-releasable pool (RRP (显示 RRBP1 ELISA试剂盒)) of Ca2 (显示 CA2 ELISA试剂盒)+ in synaptic vesicles without altering rate of priming into RRP (显示 RRBP1 ELISA试剂盒); Syt1 (显示 SYT1 ELISA试剂盒)/Syt7 functions appear redundant.
synaptotagmin 7 (Syt7) is a calcium sensor that is required for facilitation at several central synapses
Use of neurons from double-knock-out (SNAP-25 (显示 SNAP25 ELISA试剂盒), synaptotagmin-7) mice in combination with viral transduction showed that SNAP-23 (显示 SNAP23 ELISA试剂盒)-driven release is triggered by endogenous synaptotagmin-7
Complex of syt 7 and calmodulin serves as a key regulator of synaptic vesicle replenishment in presynaptic nerve terminals.
synaptotagmin-7 is directly activated by GLP-1 (显示 GCG ELISA试剂盒) signaling and may serve as a drug target for boosting insulin (显示 INS ELISA试剂盒) secretion.
knock-out of synaptotagmin-7 selectively impaired delayed asynchronous neurotransmitter release but not synchronous release. In contrast, the readily releasable vesicles after depletion recover normally in knock-out mice.
Ca(2 (显示 CA2 ELISA试剂盒)+)-triggered release at a synapse is due to synaptotagmins, with synaptotagmin-7 mediating a slower form of Ca(2 (显示 CA2 ELISA试剂盒)+)-triggered release that is normally occluded by faster synaptotagmin-1 (显示 SYT1 ELISA试剂盒)-induced release but becomes manifest upon synaptotagmin-1 (显示 SYT1 ELISA试剂盒) deletion
This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. A similar protein in rodents mediates hormone secretion and lysosome exocytosis. In humans, expression of this gene has been associated with prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
, synaptotagmin VII
, synaptotagmin 7
, prostate cancer-associated protein 7