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抗Mouse (Murine) SYT1 抗体:
抗Human SYT1 抗体:
抗Rat (Rattus) SYT1 抗体:
Rat (Rattus) Polyclonal SYT1 Primary Antibody for IHC, WB - ABIN152576
Hilfiker, Pieribone, Nordstedt, Greengard, Czernik: Regulation of synaptotagmin I phosphorylation by multiple protein kinases. in Journal of neurochemistry 1999
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Chicken Polyclonal SYT1 Primary Antibody for WB - ABIN2476661
Geertsen, Ford, Castle: The subjective aspects of coronary care. in Nursing research 1976
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Human Monoclonal SYT1 Primary Antibody for ELISA, WB - ABIN969429
Xu, Gammon, Zeisel, Lee, Wetmur, Teitelbaum, Bradshaw, Neugut, Santella, Chen: Choline metabolism and risk of breast cancer in a population-based study. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008
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Rat (Rattus) Polyclonal SYT1 Primary Antibody for ICC, WB - ABIN1742200
Shinoda, Ahmed, Ramachandran, Bharat, Brockelt, Altas, Dean: BDNF enhances spontaneous and activity-dependent neurotransmitter release at excitatory terminals but not at inhibitory terminals in hippocampal neurons. in Frontiers in synaptic neuroscience 2014
Human Monoclonal SYT1 Primary Antibody for ELISA, WB - ABIN967126
Stelzl, Worm, Lalowski, Haenig, Brembeck, Goehler, Stroedicke, Zenkner, Schoenherr, Koeppen, Timm, Mintzlaff, Abraham, Bock, Kietzmann, Goedde, Toksöz, Droege, Krobitsch, Korn, Birchmeier, Lehrach et al.: A human protein-protein interaction network: a resource for annotating the proteome. ... in Cell 2005
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Human Polyclonal SYT1 Primary Antibody for ELISA, IHC - ABIN4357223
Martens, Kozlov, McMahon: How synaptotagmin promotes membrane fusion. in Science (New York, N.Y.) 2007
tethering of Syt1 to synaptic vesicles in vivo is a prerequisite for its role in facilitating fast synchronous synaptic vesicle release and suppressing asynchronous and spontaneous fusion
synaptic transmission can be regulated by Syt1 multimerization and that both C2 domains of Syt1 are uniquely required for modulating Ca(2 (显示 CA2 抗体)+)-independent spontaneous fusion and Ca(2 (显示 CA2 抗体)+)-dependent synchronous release.
effect of APP (显示 APP 抗体) gene on synaptotagmin 1 mRNA level
The major function of Ca2+ binding to synaptotagmin's C2A domain is to neutralize the negative charge of the pocket, thereby unleashing the fusion-stimulating activity of synaptotagmin.
this study provided direct support for the hypothesis that plasma membrane penetration, specifically by the C(2)B domain of synaptotagmin, is the critical effector interaction for coupling Ca(2 (显示 CA2 抗体)+) binding with vesicle fusion
Results suggest that the tandem C2 domains of Syt 1 play independent roles in neurotransmission.
The C(2)B Ca(2+)-binding motif of synaptotagmin is required for synaptic transmission in vivo
Synaptotagmins I and IV promote transmitter release independently of Ca(2 (显示 CA2 抗体)+) binding in the C(2)A domain
Data show that synaptotagmin I is required for a post-docking step during vesicle fusion but does not function to stabilize the docked vesicle state.
These results indicate that synaptotagmin is the major Ca(2 (显示 CA2 抗体)+) sensor for evoked release and functions to trigger synchronous fusion in response to Ca(2 (显示 CA2 抗体)+), while suppressing asynchronous release.
The function of synaptotagmin-1 (syt-1):soluble NSF attachment protein (显示 NAPG 抗体) receptor (SNARE (显示 VTI1B 抗体)) interactions during neurotransmission remains unclear.
we identify Syt2 (显示 SYT2 抗体) as a functionally important Ca(2 (显示 CA2 抗体)+) sensor at fast-releasing inhibitory synapses, and show that Syt1 and Syt2 (显示 SYT2 抗体) can redundantly control transmitter release at specific brain synapses
results suggest that postsynaptic Syt1 and Syt7 (显示 SYT7 抗体) act as redundant Ca(2 (显示 CA2 抗体)+)-sensors for Ca(2 (显示 CA2 抗体)+)-dependent exocytosis of AMPA (显示 GRIA3 抗体) receptors during long-term potentiation, and thereby delineate a simple mechanism for the recruitment of AMPA (显示 GRIA3 抗体) receptors that mediates LTP (显示 SCP2 抗体)
demonstrates a developmental Syt1-Syt2 (显示 SYT2 抗体) isoform switch at an identified synapse, a mechanism that could fine-tune the speed, reliability, and plasticity of transmitter release at fast releasing CNS synapses.
the combined inactivation of all 3 E-Syt (显示 SS18 抗体) genes has no effect on mouse viability or fertility.
GRASP65 (显示 GORASP1 抗体) phosphorylation may have a critical role in inducing cell death.
We conclude that synaptotagmin-1 phosphorylation is an essential step in PKC (显示 PKC 抗体)-dependent potentiation of synaptic transmission, acting downstream of the two other essential DAG/PKC (显示 PKC 抗体) substrates, Munc13-1 (显示 UNC13A 抗体) and Munc18-1 (显示 STXBP1 抗体).
data show that hepatic Syt1 expression is influenced by diet and hormonal milieu
different structural states of syt (显示 SS18 抗体) underlie the control of distinct forms of synaptic transmission.
The interaction of Dvl1 (显示 DVL1 抗体) with Syt-1, which is regulated by Wnts, modulates neurotransmitter release.
Using electron microscopy combined with targeted mutations, the authors show that under physiologically relevant conditions, both the Syt1 ring assembly and its rapid disruption by Ca(2+) involve the well-established functional surfaces on the C2B domain that are important for synaptic transmission.
This study found that the CSF (显示 CSF2 抗体) levels of synaptotagmin-1 were consistently elevated in patients with dementia due to Alzheimer's disease.
SYT (显示 SS18 抗体)-SSX (显示 SSX2 抗体) fusion is associated with synovial sarcoma.
the extended synaptotagmins (E-Syts), endoplasmic reticulum (ER) proteins that function as PtdIns(4,5)P2- and Ca(2 (显示 CA2 抗体)+)-regulated tethers to the Pplasma membrane.
Data indicate that small protein sequence changes in the Ca(2 (显示 CA2 抗体)+)-binding loops of the C2 domains may give rise to the difference in binding kinetics between Syt-1 and Syt-7 (显示 SYT7 抗体) isoforms.
These findings identify Syt1 as a novel Ca(2 (显示 CA2 抗体)+)-sensitive PS1 (显示 PSEN1 抗体) modulator that could regulate synaptic ABETA (显示 APP 抗体), opening avenues for novel and selective synapse targeting therapeutic strategies.
One-Step reverse transcriptase real time PCR for the detection SYT (显示 SS18 抗体)-SSX (显示 SSX2 抗体) transcript is feasible as an aid in confirming the diagnosis of synovial sarcoma.
membrane tethering by E-Syt1 (显示 ESYT1 抗体) (ER to PM) and by synaptotagmin (secretory vesicles to PM) undergo a similar regulation by plasma membrane lipids and cytosolic Ca(2 (显示 CA2 抗体)+).
A dominant negative de novo SYT1 missense variant(I368T)altered the kinetics of synaptic vesicle endocytosis and caused an early onset dyskinetic movement disorder, severe motor delay, and profound cognitive impairment.
Data suggest that calcium-dependent phosphatidylinositol 4,5-diphosphate- (PI(4,5)P2-) binding proteins (such as SYT1, PRKCA (显示 PKCa 抗体) [protein kinase C alpha (显示 PKCa 抗体)], and ANXA2 (显示 ANXA2 抗体) [annexin A2 (显示 ANXA2 抗体)]) interactions with membrane microdomains are tightly regulated. [REVIEW]
The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001
, synaptoptagmin 1
, synaptotagmin 1
, synaptotagmin I
, DKFZP459P193 protein
, Synaptotagmin I
, Golgi reassembly-stacking protein 1
, golgi peripheral membrane protein p65
, golgi reassembly-stacking protein of 65 kDa
, synaptotagmin p65
, synaptotagmin 8
, synaptotagmin I VQ/C2B-beta