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These results indicate that LRRK2 (显示 LRRK2 蛋白) and alpha-synuclein participate in the dysregulation of CADPS2 by altering transcription and support the hypothesis that synaptic dysfunctions, through different mechanisms, might contribute to the neuronal defects of diseases such as Parkinson's disease.
Mutation screening of 187 patients with autism spectrum disorders and 36 with intellectual disability identified a missense change of maternal origin disrupting CADPS2/D2DR (显示 DRD2 蛋白) interaction.
We speculate that haploinsufficiency of CADPS2 contributes to ASDs.
identification, cloning, and comparative characterization of a second mammalian CAPS (显示 CAPS 蛋白) isoform, CAPS2 (显示 CAPS2 蛋白); concluded that at the functional level, CAPS2 (显示 CAPS2 蛋白) is largely redundant with CAPS1 (显示 CAPS 蛋白)
Results from Cadps2-deficient mice and human data suggest that a disturbance in CADPS2-mediated neurotrophin release contributes to autistic-like cellular and behavioral phenotypes.
CAPS (显示 CAPS PLURAL_@35257@) proteins are involved in optimizing vesicular monoamine uptake and storage mediated by VMAT1 and VMAT2 (显示 Slc18a2 PLURAL_@35257@)
CAPS2 plays an important role in subcellular locality (axonal vs. somato (显示 SSTR5 蛋白)-dendritic) of enhanced BDNF (显示 BDNF 蛋白) and NT-3 (显示 NTF3 蛋白) release, which is indispensable for proper development of postnatal cerebellum.
Data suggest that adequate levels of CAPS2 are critical for normal brain development and normal behavior; allelic changes due to copy number variation may contribute to autistic behavior.
Reduced axonal localization of a Caps2 splice variant impairs axonal release of BDNF (显示 BDNF 蛋白) and causes autistic-like behavior in mice
identification, cloning, and comparative characterization of a second mammalian CAPS (显示 CAPS 蛋白) isoform, CAPS2; concluded that at the functional level, CAPS2 is largely redundant with CAPS1 (显示 CAPS 蛋白)
results suggest that CAPS2 mediates the depolarization-dependent release of NT-3 (显示 NTF3 蛋白) and BDNF (显示 BDNF 蛋白) from granule cells, leading to regulation in cell differentiation and survival during cerebellar development
CADPS2-KO mice show autistic-like phenotypes. Moreover, the results show that some autistic patients have an aberrant splicing variant of CADPS2 mRNA, suggesting that a disturbance in CADPS2-mediated neurotrophin (显示 BDNF 蛋白) release contributes to autism.
CADPS2/CAPS2-knockout mice exhibit pronounced impairments in cerebellar development and functions. These results are also suggestive of an involvement of the CADPS2/CAPS2 gene, which is located within the AUTS1, in the cerebellar deficits of autism.
The results show the immunohistochemical localization of the CAPS (显示 CAPS 蛋白) family proteins in various mouse tissues.
The two CAPS (显示 CAPS 蛋白) family proteins are complementarily distributed throughout the various brain regions of mice.
This gene encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells. Mutations in this gene may contribute to autism susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene.
Ca2+-dependent activator protein for secretion 2
, Ca++-dependent secretion activator 2
, Ca2+-dependent activator protein
, Ca2+-dependent secretion activator
, Ca<2+-dependent activator protein for secretion
, calcium-dependent activator protein for secretion 1
, calcium-dependent secretion activator 1
, calcium-dependent activator protein for secretion 2
, calcium-dependent secretion activator 2
, cerebellum postnatal development associated protein 2