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the p (显示 CAPS 蛋白)referential binding of CAPS1 to open syntaxin-1 can (显示 STX1A 蛋白) contribute to the stabilization of the open state of syntaxin-1 during its transition from "closed" state to the SNA (显示 STX1A 蛋白)RE complex formation.
Increased level of CADPS protein, human in Schizophrenic patients
Loss of CADPS is associated with central nervous system primitive neuroectodermal tumor.
Regulation of dense core vesicle release from PC12 cells by interaction between the D2 dopamine receptor (显示 DRD2 蛋白) and calcium-dependent activator protein for secretion (CAPS (显示 CAPS 蛋白)).
CAPS1 (显示 CAPS 蛋白) protein plays an important role during protein release from secretory granules in hippocampal neurons. The cytosolic protein CAPS1 (显示 CAPS 蛋白) regulates several stages of secretory granule processing.
identified a specific interaction of CAPS1 (显示 CAPS 蛋白) with septin (显示 SEPT6 蛋白) family proteins; demonstrated that the C-terminal region of the CAPS1 (显示 CAPS 蛋白) protein binds to part of the deduced GTP-binding (显示 RND2 蛋白) domain of septin (显示 SEPT6 蛋白) proteins.
data indicate that CAPS-1 promotes fusion competence of immobile (tethered) DCVs in presynaptic terminals and that CAPS-1 localization to DCVs is probably not essential for this role
Naturally occurring splice variants of CAPS2 (显示 CADPS2 蛋白) in CAPS1/CAPS2-deficient cells were studied and found that CAPS2 (显示 CADPS2 蛋白) primes vesicles independently of its MUN domain.
Loss of CAPS1 (显示 CAPS 蛋白) disrupts the trans-Golgi network-dense-core vesicle pathway.
CAPS1 (显示 CAPS 蛋白) binds to the full-length of cytoplasmic syntaxin-1 (显示 STX1A 蛋白) with preference to its "open" conformation, whereas Munc13-1 binds to the first 80 N-terminal residues of syntaxin-1 (显示 STX1A 蛋白).
CAPS (显示 CAPS 蛋白) family proteins exert dual roles in DCV trafficking, mediating trafficking at both the secretion site for exocytosis and at the Golgi complex for biogenesis
a functional role for CAPS1 (显示 CAPS 蛋白) in regulating DCV trafficking in the trans-Golgi network; this activity occurs via protein-protein interaction with ARF4 (显示 ARF4 蛋白)/ARF5 (显示 ARF5 蛋白) in a GDP-dependent manner.
CAPS1 (显示 CAPS 蛋白) has a role in constitutive and regulated exocytosis but not in loading of transmitters into dense core vesicles
Data demonstrate that CAPS-1 and -2 generate and maintain a highly fusion competent synaptic vesicle pool that supports phasic Ca(2 (显示 CA2 蛋白)+) triggered release of transmitters.
This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described.
, Ca2+-dependent activator protein for secretion
, Ca2+-dependent secretion activator
, Ca2+-regulated cytoskeletal protein
, calcium-dependent activator protein for secretion 1
, calcium-dependent secretion activator 1
, Ca2+-dependent activator protein
, Ca<2+-dependent activator protein for secretion
, Ca<2+>dependent activator protein for secretion
, Ca++-dependent secretion activator
, calcium-dependent secretion activator 1-like