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Inhibition of Snapin enhanced localization of HIV-1 with TLR8 (显示 TLR8 ELISA试剂盒)(+) early endosomes, triggered a pro-inflammatory response, and inhibited trans-infection of CD4 (显示 CD4 ELISA试剂盒)(+) T cells.
Taken together, these results suggest that Snapin, the pUL130 interacting protein, has a role in modulating HCMV DNA synthesis.
Disruption of Snapin-PKR2 (显示 PROKR2 ELISA试剂盒) interaction did not affect PKR2 (显示 PROKR2 ELISA试剂盒) signaling, but increased the ligand-induced degradation, implying a role of Snapin in the trafficking of PKR2 (显示 PROKR2 ELISA试剂盒).
Authors propose that Snapin connects chlamydial inclusions with the microtubule network by interacting with both Chlamydia psittaci IncB and dynein.
Snapin, a SNAP (显示 NAPA ELISA试剂盒)-25 (synaptosomal-associated protein-25 (显示 SNAP25 ELISA试剂盒)) interacting protein, interacts with LRRK2 (显示 LRRK2 ELISA试剂盒).
Our findings reveal that Atg14L, previously considered to be solely a Beclin 1 (显示 BECN1 ELISA试剂盒)-binding autophagy protein, plays a novel role in the late stage of endocytic trafficking in conjunction with Snapin
These observations identify Snapin as a novel endogenous TLR2 (显示 TLR2 ELISA试剂盒) ligand in rheumatoid arthritis, and thus support a role for persistent TLR2 (显示 TLR2 ELISA试剂盒) signalling in pathogenesis.
These results suggest that Snapin may play a key role in regulating the cellular localization of human cytomegalovirus UL70, leading to modulation of viral DNA synthesis and progeny production.
PKA-dependent phosphorylation of snapin increases interaction among insulin (显示 INS ELISA试剂盒) secretory vesicle-associated proteins, thereby potentiating glucose-stimulated insulin (显示 INS ELISA试剂盒) secretion.
results suggest that RGS7 (显示 RGS7 ELISA试剂盒) could play a role in synaptic vesicle exocytosis through its interaction with snapin
Snapin-dysbindin interaction regulates synaptic vesicle positional priming through BLOC-1/AP-3-dependent sorting.
Snapin reduces APP (显示 APP ELISA试剂盒) processing by enhancing BACE1 (显示 BACE ELISA试剂盒) lysosomal degradation.
Transmembrane prostatic acid phosphatase (显示 ACPP ELISA试剂盒) (TMPAP) interacts with snapin and deficient mice develop prostate adenocarcinoma.
Snapin accelerates exocytosis at low intracellular calcium concentration in mouse chromaffin cells.
Snapin-dynein coupling is one of the primary mechanisms driving BDNF (显示 BDNF ELISA试剂盒)-TrkB (显示 NTRK2 ELISA试剂盒) retrograde transport, thus providing mechanistic insights into the regulation of neuronal growth and survival.
AC6 (显示 ADCY6 ELISA试剂盒)-mediated inhibition of neurite outgrowth was reversed by the overexpression of Snap25 (显示 SNAP25 ELISA试剂盒) or a Snapin mutant that could not be phosphorylated.
Snapin has a role in regulating autophagy-lysosomal function
Snapin deficiency leads to reduced cell density in cortical plates, apoptotic death in the cortex & third ventricle, enhanced membrane-bound LC3 (显示 MAP1LC3A ELISA试剂盒)-II staining, and accumulation of polyubiquitinated proteins in the cortex and hippocampus in knockout mice
highlights new mechanistic insights into how Snapin-intermediate chain coordinates retrograde transport and late endosomal-lysosomal trafficking critical for autophagy-lysosomal function, and thus neuronal homeostasis.
The protein encoded by this gene is a coiled-coil-forming protein that associates with the SNARE (soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor) complex of proteins and the BLOC-1 (biogenesis of lysosome-related organelles) complex. Biochemical studies have identified additional binding partners. As part of the SNARE complex, it is required for vesicle docking and fusion and regulates neurotransmitter release. The BLOC-1 complex is required for the biogenesis of specialized organelles such as melanosomes and platelet dense granules. Mutations in gene products that form the BLOC-1 complex have been identified in mouse strains that are models of Hermansky-Pudlak syndrome. Alternative splicing results in multiple transcript variants.
, SNARE-associated protein Snapin
, BLOC-1 subunit 7
, SNAP-25-binding protein
, SNARE associated protein snapin
, biogenesis of lysosomal organelles complex-1, subunit 7
, biogenesis of lysosome-related organelles complex 1 subunit 7
, synaptosomal-associated protein 25-binding protein
, synaptosomal-associated protein 25 binding protein
, synaptosomal-associated protein, 25 kDa, binding protein