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Electrophysiological characterization of VDCC currents revealed that the suppressive effect of RIM2alpha on voltage-dependent inactivation (VDI) was stronger than that of RIM1alpha for the CaV2.1 (显示 CACNA1A ELISA试剂盒) variant containing the region encoded by exons 44 and 47.
The function of RIM1/2 at rod ribbons is to enhance Cav1.4 (显示 CACNA1F ELISA试剂盒) channel activity, possibly through direct or indirect modulation of the channel.
Experiments with single Rim 1/2 gene inactivation at the large calyx of Held synapse show largely overlapping roles of the two major Rim genes in vesicle priming/docking
RIM1alpha can influence short-term plasticity at cerebellar parallel-fibre synapses.
betaARs couple to a cAMP/Epac (显示 RAPGEF3 ELISA试剂盒)/PLC (显示 HSPG2 ELISA试剂盒)/Munc13-1 (显示 UNC13A ELISA试剂盒)/Rab3a (显示 RAB3A ELISA试剂盒)/RIM1a-dependent pathway to enhance glutamate (显示 GRIN1 ELISA试剂盒) release at cerebrocortical nerve terminals.
RIM1alpha has a role in synaptic vesicle tethering.
Presynaptic plasticity and function of RIM1a play an important part in the neuron's adaptive response to aberrant electrical activity following pharmacologically induced status epielepticus.
The interaction between RIM1alpha and Munc13-1 (显示 UNC13A ELISA试剂盒) is required for presynaptic long-term plasticity
Data suggest that RIM1/2 proteins co-ordinately regulate key functions for fast transmitter release, enabling a high presynaptic Ca(2 (显示 CA2 ELISA试剂盒))+ channel density and vesicle docking at the active zone.
RIM1alpha interacts with several active zone molecules, including Munc13-1 (显示 UNC13A ELISA试剂盒) and alpha-liprins, to form a protein scaffold in the presynaptic nerve terminal.
This is the first reported case of bilateral cystoid macular edema in association with the RIM1 mutation. Overall, our findings were more consistent with a phenotype of retinitis pigmentosa.
The study identified a region on chromosome 6 comprising the genes SMAP1 (显示 UNC45A ELISA试剂盒), B3GAT2 (显示 B3GAT2 ELISA试剂盒), and RIMS1 as novel susceptibility locus for pediatric venous thromboembolism.
Here, we report that, like Rab3A (显示 RAB3A ELISA试剂盒), RIM (显示 RBBP8 ELISA试剂盒) and Munc13 (显示 UNC13B ELISA试剂盒) are present in human sperm and that they play a functional role in acrosomal exocytosis before the acrosomal calcium efflux
a novel functional coupling between RIM1 and the L-type Ca(V) channels via the Ca(V)beta auxiliary subunit that contribute to determine insulin (显示 INS ELISA试剂盒) secretion.
Rim1 modulates direct G-protein regulation of Ca(v)2.2 channels.
Rim1 is a component of the presynaptic active zone and modulator of exocytosis and binds 14-3-3 (显示 YWHAQ ELISA试剂盒) through its N terminus
Even though the absence of pathogenic mutations suggests that RIM1 is notinvolved in autosomal recessive retinitis pigmentosa.
A possible role for RIMS1 in the enhancement of cognitive function at least in this kindred is suggested.
The protein encoded by this gene is a RAS gene superfamily member that regulates synaptic vesicle exocytosis. This gene also plays a role in the regulation of voltage-gated calcium channels during neurotransmitter and insulin release. Mutations have suggested a role cognition and have been identified as the cause of cone-rod dystrophy type 7. Multiple transcript variants encoding different isoforms have been described for this gene.
regulating synaptic membrane exocytosis 1
, regulating synaptic membrane exocytosis protein 1-like
, regulating synaptic membrane exocytosis protein 1
, RIM 1
, Rab3 effector
, Rab3 interacting protein 1
, rab-3-interacting molecule 1
, rab-3-interacting protein 1
, rab3-interacting molecule 1
, rab3-interacting protein 1
, synaptic exocytosis regulator 1
, RAB3-interacting protein 2
, rab-3-interacting protein 2
, Rim1b protein