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Coinjection of low doses of morpholinos for beta-neurexin 1a and neuroligin 1 together or in combination with morpholinos targeting the -heparin--binding isoforms of vascular endothelial growth factor A (显示 VEGFA 蛋白) recapitulates the observed abnormalities
We show that a novel NLGN1 Pro89Leu (P89L) missense variant found in two autism spectrum disorder (ASD (显示 ARSD 蛋白)) siblings leads to changes in cellular localization, protein degradation, and to the impairment of spine formation. Furthermore, we generated the knock-in P89L mice, and we show that the P89L heterozygote mice display abnormal social behavior, a core feature of ASD (显示 ARSD 蛋白)
the expression of NL1 and its binding partner neurexin (显示 NRXN1 蛋白)-1beta was increased in temporal lobe epileptic foci in patients and lithium-pilocarpine-treated epileptic rats.
Neuroligin 1 (NL1) promotes the formation of glutamatergic synapses and mediates long-term potentiation.
NLGN1 was associated with schizophrenia in Chinese Han Populations
Increasing expression of TGF-beta1 (显示 TGFB1 蛋白) protein, decreasing expressions of Ghrelin (显示 GHRL 蛋白), Neurexin (显示 NRXN1 蛋白), and Neuroligin proteins can induce the loss or dysfunction of ganglion cells in distal intestinal canal
Neuroligin-1 and Glu (显示 DCTN1 蛋白) may represent new markers of ganglion cells, whose expression may correlate with the pathogenesis, diagnosis, differential diagnosis or classification of Hirschsprung's disease.
Results indicate that the neurexin (显示 NRXN1 蛋白) and neuroligin synaptic complex is intrinsically involved in the regulation of DISC1 (显示 DISC1 蛋白) function, thus contributing to a better understanding of the pathology of schizophrenia.
Monitoring the attachment and detachment of neurexin (Nrx (显示 NRXN1 蛋白))-coated quantum dots measures the rates of neurexin (Nrx (显示 NRXN1 蛋白))/neuroligin interaction in the hippocampus.
We identified a cluster of single nucleotide polymorphisms at the NLGN1 locus showing significant association with BP variability. Follow-up analyses did not support an association with risk of ischemic stroke and its subtypes
Expression levels of neurexin (显示 NRXN1 蛋白) and neuroligin in ENS are significantly down-regulated in HSCR (显示 EDNRB 蛋白), which may be involved in the pathogenesis of HSCR (显示 EDNRB 蛋白).
The alternatively spliced segment 4 (AS4) of NRX genes (Nrxn) is a critical element in selective trans-synaptic interactions. This study evaluated the synaptogenic receptor activity of NL1/2/3 isoforms in a neuron-fibroblast co-culture system, in which the Nrxn AS4 segments are manipulated using SLM2, a selective and dominant regulator of AS4 splicing.
We show that a novel NLGN1 Pro89Leu (P89L) missense variant found in two autism spectrum disorder (ASD (显示 GUSB 蛋白)) siblings leads to changes in cellular localization, protein degradation, and to the impairment of spine formation. Furthermore, we generated the knock-in P89L mice, and we show that the P89L heterozygote mice display abnormal social behavior, a core feature of ASD (显示 GUSB 蛋白)
The results indicate that Nrx2alpha and NL1 (显示 MMEL1 蛋白) are targets of Abeta (显示 APP 蛋白) oligomers and that prevention of this interaction reduces the deleterious impact of Abeta (显示 APP 蛋白) oligomers on synapses and cognition.
Neuroligin 1 regulates spines and synaptic plasticity via LIMK1/cofilin-mediated actin reorganization.
Study shows that astrocyte-secreted hevin is a trans-synaptic linker that bridges presynaptic NRX1alpha with postsynaptic NL1B. This way, hevin organizes both pre- and postsynaptic specializations and aligns them across the synapse.
Results are indicative of an altered immediate response of the brain to peripheral stimulation in Nlgn1 KO mice, and suggest a role for NLGN1 in the regulation of cerebrovascular responses
the R451C mutation in the Nlgn3 (显示 NLGN3 蛋白) gene, associated with autism spectrum disorder in humans, confers resistance to induced seizures
This study provided first evidence that NL1 (显示 MMEL1 蛋白) is essential for normal excitatory transmission and long-term synaptic plasticity in the hippocampus of intact animals.
NLGN1 and alpha6 integrin preferentially colocalize in the mature retinal vessels, whereas NLGN1 deletion causes an aberrant VE-cadherin (显示 CDH5 蛋白), laminin and alpha6 integrin distribution in vessels
This study demonistrated that amyloid-induced neuroinflammation leads to epigenetic suppression of NLGN1 expression.
transmembrane ligand for neurexins\; involved in development and maturation of synaptic connections
, neuroligin I
, neuroligin 1 isoform A1A2B