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Human CX3CL1 Protein expressed in Escherichia coli (E. coli) - ABIN803628
Yoong, Too: Glial cell line-derived neurotrophic factor and neurturin inhibit neurite outgrowth and activate RhoA through GFR alpha 2b, an alternatively spliced isoform of GFR alpha 2. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2007
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Human CX3CL1 Protein expressed in Human Cells - ABIN2003167
Bazan, Bacon, Hardiman, Wang, Soo, Rossi, Greaves, Zlotnik, Schall: A new class of membrane-bound chemokine with a CX3C motif. in Nature 1997
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Human CX3CL1 Protein expressed in - ABIN621641
Kim, Rooper, Xie, Kajdacsy-Balla, Barbolina: Fractalkine receptor CX(3)CR1 is expressed in epithelial ovarian carcinoma cells and required for motility and adhesion to peritoneal mesothelial cells. in Molecular cancer research : MCR 2012
in this study, CX3CL1 is identified as a novel substrate of MMP-19 (显示 MMP19 蛋白)
The CX3CL1/CX3CR1 (显示 CX3CR1 蛋白) system is essential for restricting coxsackievirus B3-induced myocarditis.
changes in GSK-3beta activity and/or levels regulate the production and subsequent secretion of fractalkine, a chemokine (显示 CCL1 蛋白) involved in the immune response that has been linked to AD and to other different neurological disorders.
the individual and combined actions of CCL2 (显示 CCL2 蛋白)/CCR2 (显示 CCR2 蛋白) and CX3CL1/CX3CR1 (显示 CX3CR1 蛋白) in hypoxia-induced pulmonary hypertension in mice, is reported.
Medial ganglionic eminence (MGE) interneurons secrete fractalkine that promotes genesis of oligodendrocytes from glially biased cortical precursors in culture. Moreover, when MGE interneurons are genetically ablated in vivo prior to their migration, this causes a deficit in cortical oligodendrogenesis.
our findings reveal a previously unknown regulatory role for LRRK2 (显示 LRRK2 蛋白) in CX3CR1 (显示 CX3CR1 蛋白) signalling and suggest that an increase of CX3CR1 (显示 CX3CR1 蛋白) activity contributes to the attenuated inflammatory responses in Lrrk2 (显示 LRRK2 蛋白)-null microglia
a crucial role of CX3CL1-CX3CR1 (显示 CX3CR1 蛋白) in experimental colitis, in particular for intestinal leukocyte recruitment during murine colitis, is reported.
These results strongly suggest the involvement of CX3CL1 in the migration of osteoclast precursors and osteoclastogenesis.
Authors provide evidence that interactions between CX3CL1 and CX3CR1 (显示 CX3CR1 蛋白) play crucial roles in determining the number of M1 macrophages within the skin of mice, which in turn can have dramatic effects on psoriasis-like inflammation.
In the absence of the rd8 allele, deficiency of CCR2 (显示 CCR2 蛋白) and CX3CL1 in mice leads to a mild form of retinal degeneration which is associated with the recruitment of macrophages, particularly to the subretinal space. This model enables to assess consequences of perturbed chemokine (显示 CCL1 蛋白) signaling, but it does not recapitulate cardinal (显示 CARD8 蛋白) age-related macular degeneration features.
Data indicate that patients with systemic sclerosis (SSc (显示 CYP11A1 蛋白)) displayed higher serum levels of VEGF (显示 VEGFA 蛋白), endothelin-1 (显示 EDN1 蛋白) and s-Fractalkine, and that the s-Fractalkine levels positively correlated with CD34 (显示 CD34 蛋白)(+)CD45 (显示 PTPRC 蛋白)(-) endothelial progenitor cells (EPC (显示 TCF21 蛋白)) numbers.
FKN and CX3CR1 (显示 CX3CR1 蛋白) expression was significantly increased in pancreatic ductal adenocarcinoma (PDAC) tissues, especially in the metastatic samples, and was highly-correlated with severity of PDAC. Ectopic expression of FKN promoted the proliferation and migration of PDAC, while knockdown of CX3CR1 (显示 CX3CR1 蛋白) reversed the function of FKN.
Fractalkine may be involved in both immunopathological and anti-viral immune responses to rhinovirus infection in asthma.
High CX3CL1 expression is associated with spinal metastases.
High expression of CX3CR1 (显示 CX3CR1 蛋白) correlates with significantly shorter survival, specifically in post-menopausal patients with advanced and terminal stages of the disease. Taken together, this support a key regulatory role for the fractalkine axis in advanced and relapsed peritoneal metastasis in epithelial ovarian carcinoma.
In conclusion, leukoplakia-associated fibroblasts produced and secreted less CX3CL1 by inhibiting the ERK (显示 EPHB2 蛋白) signaling pathway, thereby contributing to impaired cell resistance to Candida albicans.
Fractalkine-CX3CR1 (显示 CX3CR1 蛋白) signaling has been shown to protect neurons.
CX3CL1 exerts numerous effects on pathophysiological conditions that have both negative and positive consequences on pathogenesis and outcome [review]
XCL2 (显示 XCL2 蛋白) and CX3CL1 expression in lung cancers and adjacent non-cancerous tissues was detected by quantitative PCR and ELISA. The expression of XCL2 (显示 XCL2 蛋白) and CX3CL1 increases with increasing degree of malignancy, indicating that both chemokines might be important targets in gene therapy for lung cancer.
Chemotactic factor. Binds to CX3CR1.
, chemokine (C-X3-C motif) ligand 1
, chemokine (C-X3-C motif) ligand 1, related sequence 1
, small inducible cytokine subfamily D, 1-related sequence 1
, CX3CL1 chemokine
, C-X3-C motif chemokine 1
, CX3C membrane-anchored chemokine
, small inducible cytokine subfamily D, 1
, small-inducible cytokine D1
, small inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, neurotactin)
, small inducible cytokine subfamily D (Cys-X3-Cys), member-1