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The analysis points to a critical role for Hoxa9 (显示 HOXA9 ELISA试剂盒) and PU.1 in distal regulation of c-myb (显示 MYB ELISA试剂盒) expression in murine myeloid cells during iL-6 (显示 IL6 ELISA试剂盒)-induced cell differentiation.
These studies reveal an important role for PU.1 in the regulation of Igkappa transcription and rearrangement and a requirement for PU.1 and Spi-B (显示 SPIB ELISA试剂盒) in B cell development.
expression of an essential mediator of neutrophil terminal differentiation, the ets transcription factor PU.1, was significantly decreased in Hbb(th3/+) neutrophils in a model of beta-thalassemia
Moreover, the expression of a cell proliferation marker Ki67 (显示 MKI67 ELISA试剂盒) was significantly decreased in tumors from the mice not taking doxycycline, compared with that of tumors from the mice continuously taking doxycycline. The present data strongly suggest that PU.1 functions as a tumor suppressor of myeloma cells in vivo.
the affinities of two sequence-divergent ETS (显示 ETS1 ELISA试剂盒) homologs, PU.1 and Ets-1 (显示 ETS1 ELISA试剂盒), to DNA sites harboring a hemi- and fully methylated CpG dinucleotide, were measured.
this study shows that PU.1 functions as a positive regulator of CD11c (显示 ITGAX ELISA试剂盒) gene expression by directly binding to the Itgax (显示 ITGAX ELISA试剂盒) promoter and through transactivation of the Irf4 (显示 IRF4 ELISA试剂盒) gene
Here we demonstrate that the transcription factors SPI1 (PU.1) and HOXC13 synergistically regulate Zfp521 expression, and identify the regions of the Zfp521 promoter required for this transcriptional activity. We also show that SPI1 and HOXC13 activate Zfp521 in a dose-dependent manner.
findings suggest that Gata1 (显示 GATA1 ELISA试剂盒) & PU.1 transcription factors are only executing and reinforcing lineage choice once made. These results challenge the current prevailing model of early myeloid lineage choice
involved in osteoclast development by transactivating NFATc1 (显示 NFATC1 ELISA试剂盒) expression via direct binding to the NFATc1 (显示 NFATC1 ELISA试剂盒) promoter
GATA1 (显示 GATA1 ELISA试剂盒) and PU.1 bind in vitro and in vivo the proximal promoter region of the RPS19 (显示 RPS19 ELISA试剂盒) gene which is frequently mutated in Diamond-Blackfan Anemia.
PU.1-induced apoptosis in myeloma cells is associated with IRF4 (显示 IRF4 ELISA试剂盒) downregulation and subsequent IRF7 (显示 IRF7 ELISA试剂盒) upregulation.
Most cases of histiocytic sarcoma expressed histiocytic markers CD68 (显示 CD68 ELISA试剂盒) (6 of 7 cases), CD163 (显示 CD163 ELISA试剂盒) (5 of 5 cases), and PU.1 (3 of 4 cases).
findings highlight a unique role of SPI1 fusions in high-risk pediatric T cell acute lymphoblastic leukemia
expression of an essential mediator of neutrophil terminal differentiation, the ets transcription factor PU.1, was significantly decreased in Hbb(th3/+) neutrophils in beta-thalassemia
RUNX1 (显示 RUNX1 ELISA试剂盒) overexpression induced partial DNA demethylation at SPI1 proximal promoter.
This study demonstrated the novel role of PU.1 in the immune response to A. fumigatus through upregulation of Dectin-1 (显示 CLEC7A ELISA试剂盒) expression and its translocation to the nucleus in A. fumigatus-stimulated THP-1 (显示 GLI2 ELISA试剂盒) cells.
PU.1 is an important modulator of VDR (显示 CYP27B1 PLURAL_@5515@) signaling in monocytes.
Forced FOG1 protein expression in K562 erythroleukemia cells induced the expression of SLC4A1 (显示 SLC4A1 ELISA试剂盒) protein, but repressed that of transcription factor PU.1.
we demonstrated that miR (显示 MLXIP ELISA试剂盒)-22 promoted monocyte/macrophage differentiation, and MECOM (EVI1 (显示 MECOM ELISA试剂盒)) mRNA is a direct target of miR (显示 MLXIP ELISA试剂盒)-22 and MECOM (EVI1 (显示 MECOM ELISA试剂盒)) functions as a negative regulator in the differentiation.The miR (显示 MLXIP ELISA试剂盒)-22-mediated MECOM (显示 MECOM ELISA试剂盒) degradation increased c-Jun (显示 JUN ELISA试剂盒) but decreased GATA2 (显示 GATA2 ELISA试剂盒) expression, which results in increased interaction between c-Jun (显示 JUN ELISA试剂盒) and PU.1
The vertical and paralleled Pu.1/Spi-b (显示 SPIB ELISA试剂盒) regulatory networks control the development of rostral blood island and ventral wall of dorsal aorta-borne macrophages by regulating Irf8 (显示 IRF8 ELISA试剂盒).
eaf1 has a role in suppressing foxo3b expression to modulate transcriptional activity of gata1 (显示 GATA1 ELISA试剂盒) and spi1 in primitive hematopoiesis
Our results indicate that Kzp (显示 ANPEP ELISA试剂盒) is a critical transcriptional factor for the expression of gata2 and pu.1 to modulate primitive hematopoiesis.
Runx1 (显示 RUNX1 ELISA试剂盒) is induced by high Pu.1 level and in turn transrepresses pu.1 expression, thus constituting a negative feedback loop that fashions a favorable Pu.1 level required for balanced fate commitment to neutrophils versus macrophages.
The authors show that tif1gamma (显示 TRIM33 ELISA试剂盒) modulates the erythroid versus myeloid fate outcomes from HSCs by differentially controlling the levels of gata1 (显示 GATA1 ELISA试剂盒) and pu.1.
found a gene group downregulated on spi1 knockdown,containing all 5 previously identified Spi1-dependent genes as well as a large set of novel immune-related genes
In zebrafish, spi1 marks a rostral population of LPM cells committed to a myeloid fate anatomically separated from and developmentally independent of erythroid commitment in the caudal (显示 CAD ELISA试剂盒) LPM.
This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene.
, contrapsin-like protease inhibitor 3
, contrapsin-like protease inhibitor-related protein
, liver regeneration protein lrryan
, serine protease inhibitor 1
, serine protease inhibitor 2.1
, serine protease inhibitor 2a
, serine protease inhibitor A3L
, serpin A3L
, 31 kDa transforming protein
, 31 kDa-transforming protein
, SPI-1 proto-oncogene
, hematopoietic transcription factor PU.1
, spleen focus forming virus (SFFV) proviral integration oncogene spi1
, transcription factor PU.1
, SFFV proviral integration 1 protein
, SFFV proviral integration 1
, spleen focus forming virus proviral integration oncogene spi1
, Spi-1/PU.1 transcription factor
, transcription factor spi1