anti-PRDM16 (PRDM16) 抗体产品概述

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anti-PR Domain Containing 16 抗体 (PRDM16)
在www.antibodies-online.cn可供69 PR Domain Containing 16 (PRDM16) 抗体的16不同的供货商。 再加上,我们可以发PRDM16 蛋白 (11)PRDM16 试剂盒 (1)和数多这个蛋白质的别的产品。 总共85 PRDM16产品已列进来了。
别名:
5730557K01Rik, C130091E20, csp1, mel1, mKIAA1675, PFM13, PRDM16, wu:fc09g08
列出全部抗体 基因 基因ID UniProt
PRDM16 63976 Q9HAZ2
PRDM16 70673 A2A935
PRDM16 100366024  

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引用最多的anti-PRDM16 抗体

  1. Human Polyclonal PRDM16 Primary Antibody for ELISA - ABIN249627 : Stanford, Middelbeek, Townsend, An, Nygaard, Hitchcox, Markan, Nakano, Hirshman, Tseng, Goodyear: Brown adipose tissue regulates glucose homeostasis and insulin sensitivity. in The Journal of clinical investigation 2013 (PubMed)
    Show all 2 references for 249627

  2. Human Polyclonal PRDM16 Primary Antibody for ELISA, ICC - ABIN4347210 : Baskaran, Krishnan, Ren, Thyagarajan: Capsaicin induces browning of white adipose tissue and counters obesity by activating TRPV1 channel-dependent mechanisms. in British journal of pharmacology 2016 (PubMed)

  3. Human Polyclonal PRDM16 Primary Antibody for ELISA, WB - ABIN184809 : Mochizuki, Shimizu, Nagasawa, Tanaka, Taniwaki, Yokota, Morishita: A novel gene, MEL1, mapped to 1p36.3 is highly homologous to the MDS1/EVI1 gene and is transcriptionally activated in t(1;3)(p36;q21)-positive leukemia cells. in Blood 2000 (PubMed)

更多抗PRDM16的相互作用对抗体

Zebrafish PR Domain Containing 16 (PRDM16) interaction partners

  1. Prdm3 (显示 MECOM 抗体) and prdm16 are strongly expressed in the pharyngeal arches during cranioskeletal development, and their knockdown leads to defects in both the viscerocranium and the neurocranium.

Cow (Bovine) PR Domain Containing 16 (PRDM16) interaction partners

  1. Animals with the homozygote PRDM16 genotype had lower body weight and average daily gain than those with the other genotypes.

  2. The genetic variation within PRDM16 gene in 1031 Chinese indigenous bovine, was analyzed.

Human PR Domain Containing 16 (PRDM16) interaction partners

  1. Flow cytometric analysis and western blot analysis of apoptosisassociated proteins indicated that PRDM16 has an antiapoptotic role in prostatic cancer cells. In addition, the spliced form, sPRDM16/MEL1S, was detected to be overexpressed in PCa (显示 FLVCR1 抗体) cell lines. In conclusion, the present study indicated an important oncogenic role in prostate cancer.

  2. A single risk variant, rs2651899 in PRDM16, was significantly associated with efficacy of triptans in migraine patients

  3. High PRDM16 expression is associated with astrocytoma.

  4. Our results suggest that K568 SUMOylation of sPRDM16 plays an important role in the progression of acute myeloid leukemia (显示 BCL11A 抗体).

  5. Results show that PRDM16 overexpression was highly recurrent in de novo paediatric AML (显示 RUNX1 抗体) and is associated with adverse outcome

  6. PRDM16 might contribute to maintain adipose tissue "white fat" gene expression profile and systemic metabolic homeostasis.

  7. EVI1 (显示 MECOM 抗体) and MEL1 are homolog genes whose transcriptional activations by chromosomal translocations have roles in Japanese pediatric acute myeloid leukemia (显示 BCL11A 抗体)

  8. Three novel loci were identified in East Asians with cardiac arrhythmias: rs2483280 (PRDM16 locus) and rs335206 (PRDM6 (显示 PRDM6 抗体) locus) were associated with QRS (显示 QARS 抗体) duration; and rs17026156 (SLC8A1 (显示 SLC8A1 抗体) locus) correlated with PR interval.

  9. Genetic analyses uncovered the importance of the PRDM16 gene in the regulation of lean body mass.

  10. MED1 (显示 MED1 抗体) is required for optimal PRDM16-induced Ucp1 (显示 UCP1 抗体) expression

Mouse (Murine) PR Domain Containing 16 (PRDM16) interaction partners

  1. Gelidium elegans stimulates the expression of PRDM16 and UCP-1 (显示 UCP1 抗体) Protein in brown adipose tissue and suppresses hyperglycemia in high-fat diet mice.

  2. Both gain- and loss-of-function studies showed that an accumulation of the CCAAT/enhancer binding protein-beta (C/EBP-beta (显示 CEBPB 抗体)) protein, which cooperates with dominant transcriptional co-regulator PR domain containing 16 (PRDM16) to determine brown/beige (显示 LYST 抗体) adipocyte lineage, is essential for the enhanced adipocyte browning caused by the loss of ZIP13 (显示 SLC39A13 抗体)

  3. Prdm16 plays an important role in dynamic cellular redox changes in developing neocortex during neural differentiation.

  4. Together, these data indicate that PRDM16 diminishes responsiveness to type I interferon (显示 IFNA 抗体) in adipose cells to promote thermogenic and mitochondrial function.

  5. the cellular levels of alpha-ketoglutarate (alphaKG), a key metabolite required for TET-mediated DNA demethylation, were profoundly increased and required for active DNA demethylation of the Prdm16 promoter.

  6. We further show that Cdkn1c (显示 CDKN1C 抗体) is required for post-transcriptional accumulation of the brown fat determinant PR domain containing 16 (PRDM16) and that CDKN1C (显示 CDKN1C 抗体) and PRDM16 co-localise to the nucleus of rare label-retaining cell within iBAT (显示 SLC10A2 抗体).

  7. PRDM16-induced C2C12 transdifferentiation is associated with alterations in CpG methylation of myogenic factors, and PR domain affects both myogenesis and adipogenesis with modified histone methylation marks on MyoD (显示 MYOD1 抗体) and PPARgamma (显示 PPARG 抗体) promoters

  8. PRDM16 deficiency in BAT (显示 BAAT 抗体) reduces MED1 (显示 MBD4 抗体) binding at PRDM16 target sites and causes a fundamental change in chromatin architecture at key brown fat-selective genes

  9. Prdm16 and Prdm3 (显示 MECOM 抗体) control postnatal BAT (显示 BAAT 抗体) identity and function.

  10. Study reveals that Prdm16 expression is regulated through Gcn5 (显示 KAT2A 抗体)/PCAF (显示 KAT2B 抗体) during brown adipogenesis.

PRDM16 抗原简介

Antigen Summary

The reciprocal translocation t(1\;3)(p36\;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Alternative names and synonyms associated with PRDM16

  • PR domain containing 16 (PRDM16) 抗体
  • PR domain containing 16 (prdm16) 抗体
  • PR domain containing 16 (Prdm16) 抗体
  • 5730557K01Rik 抗体
  • C130091E20 抗体
  • csp1 抗体
  • mel1 抗体
  • mKIAA1675 抗体
  • PFM13 抗体
  • PRDM16 抗体
  • wu:fc09g08 抗体

Protein level used designations for PRDM16

PR domain containing 16 , fc09g08 , PR domain zinc finger protein 16-like , MDS1/EVI1-like gene 1 , PR domain zinc finger protein 16 , transcription factor MEL1 , PR domain-containing protein 16 , line 27

GENE ID SPECIES
419388 Gallus gallus
457227 Pan troglodytes
559174 Danio rerio
100060844 Equus caballus
100137803 Bos taurus
100481590 Ailuropoda melanoleuca
100592850 Nomascus leucogenys
63976 Homo sapiens
70673 Mus musculus
100366024 Rattus norvegicus
479582 Canis lupus familiaris
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