Use your antibodies-online credentials, if available.
Select your species
The functional cloning, expression pattern, overexpression, and knockdown data show that an ldb1-regulated mechanism acts as an early signal for Xenopus lens induction.
Data show that mediator is recruited to the beta-globin (显示 HBB ELISA试剂盒) locus by the LDB1 complex.
Genome-wide analysis indicated that LMO2 (显示 LMO2 ELISA试剂盒) is required at the hemangioblast stage to position the TAL1 (显示 TAL1 ELISA试剂盒)/LMO2 (显示 LMO2 ELISA试剂盒)/LDB1 complex to regulatory elements that are important for the establishment of the hematopoietic developmental program.
LDB1 regulates energy homeostasis, in part through transcriptional modulation of critical regulators in brown adipose tissue function.
an essential cell-autonomous role for Ldb1 in the development of dopaminergic neurons, is reported.
An intricate regulatory network exists that is mediated by Ldb1 and Ldb2 (显示 LDB2 ELISA试剂盒), and promotes retinal progenitor cells proliferation and multipotency; it also controls specification of mammalian retina cells.
LDB1 maintains the terminally differentiated state of beta cells and is a component of active enhancers in both murine and human islets.
CLIM interacts with estrogen receptor alpha (显示 ESR1 ELISA试剂盒) at the H19 (显示 NCKAP1 ELISA试剂盒) locus, potentially explaining the higher expression of H19 (显示 NCKAP1 ELISA试剂盒) in female than male corneas.
SSBP3 (显示 SSBP3 ELISA试剂盒) Interacts With Islet-1 (显示 ISL1 ELISA试剂盒) and Ldb1 to Impact Pancreatic beta-Cell Target Genes
the Isl1 (显示 ISL1 ELISA试剂盒)/Ldb1 complex orchestrates a network for heart-specific transcriptional regulation and coordination in three-dimensional space during cardiogenesis.
results indicate that LDB1-dependent looping events can deliver repressive cargo to cognate promoters to mediate promoter pausing events in a pituitary cell type
Alanine scanning mutagenesis of the LIM (显示 PDLIM5 ELISA试剂盒) interaction domain of LDB1 revealed a discrete motif, R(320)LITR, required for LMO2 (显示 LMO2 ELISA试剂盒) binding.
Clim2, in a complex with LMO4 (显示 LMO4 ELISA试剂盒), supports mammary stem cells by directly targeting the Fgfr2 (显示 FGFR2 ELISA试剂盒) promoter in basal cells to increase its expression
In t(8;21) leukemia cells, LDB1 functions as a component of the stable AML1 (显示 RUNX1 ELISA试剂盒)-ETO (显示 RUNX1T1 ELISA试剂盒)-containing transcription factor complex (AETFC). The AETFC components cooperatively regulate gene expression and contribute to leukemogenesis.
We investigated NLI (Ldb1 homolog) complex occupancy and chromatin conformation of the beta-globin (显示 HBB ELISA试剂盒) locus in human erythroid cells.
These studies are consistent with a model in which TIF1gamma (显示 TRIM33 ELISA试剂盒) acts to ubiquitinate LDB1 leading to degradation of LDB1 and changes in transcription of LDB1-dependent promoters.
Expression of LDB1 (LIM-domain-binding 1) protein in which Lys134 is replaced with arginine leads to enhanced expression of the mutant protein compared with the wild-type protein.
1H, 15N and 13C assignments of FLIN4, an intramolecular LMO4 (显示 LMO4 ELISA试剂盒):ldb1 complex
Ssdp (显示 SSBP3 ELISA试剂盒) proteins interact with the LIM (显示 PDLIM5 ELISA试剂盒)-domain-binding protein Ldb1 to regulate development
Centrosome movements in vivo correlate with specific neurite formation downstream of LIM homeodomain transcription factor activity.
Study identifies a number of novel Ldb1 interacting proteins in murine erythroleukaemic cells, namely Eto-2 (显示 CBFA2T3 ELISA试剂盒), the cyclin-dependent kinase (显示 CDK1 ELISA试剂盒) Cdk9 (显示 CDK9 ELISA试剂盒), Lmo4 (显示 LMO4 ELISA试剂盒); morphilino-mediated knockdowns in zebrafish show these factors to be essential for haematopoiesis.
Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors.
, LIM domain-binding factor CLIM2
, LIM domain-binding protein 1
, carboxyl-terminal LIM domain-binding protein 2
, nuclear LIM interactor
, neural Src-interacting protein
, neural src interacting protein
, LIM domain-binding factor-1
, carboxy terminal LIM domain protein 2
, LIM-domain binding factor 1