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抗Mouse (Murine) LIM Domain Binding 1 Protein 抗体:
抗Human LIM Domain Binding 1 Protein 抗体:
抗Rat (Rattus) LIM Domain Binding 1 Protein 抗体:
Human Polyclonal LIM Domain Binding 1 Protein Primary Antibody for ICC, IF - ABIN4330562
Li, Ponten, dos Remedios: The interactome of LIM domain proteins: the contributions of LIM domain proteins to heart failure and heart development. in Proteomics 2012
Show all 2 Pubmed References
The functional cloning, expression pattern, overexpression, and knockdown data show that an ldb1-regulated mechanism acts as an early signal for Xenopus lens induction.
Data show that mediator is recruited to the beta-globin (显示 HBB 抗体) locus by the LDB1 complex.
Genome-wide analysis indicated that LMO2 (显示 LMO2 抗体) is required at the hemangioblast stage to position the TAL1 (显示 TAL1 抗体)/LMO2 (显示 LMO2 抗体)/LDB1 complex to regulatory elements that are important for the establishment of the hematopoietic developmental program.
LDB1 regulates energy homeostasis, in part through transcriptional modulation of critical regulators in brown adipose tissue function.
an essential cell-autonomous role for Ldb1 in the development of dopaminergic neurons, is reported.
An intricate regulatory network exists that is mediated by Ldb1 and Ldb2 (显示 LDB2 抗体), and promotes retinal progenitor cells proliferation and multipotency; it also controls specification of mammalian retina cells.
LDB1 maintains the terminally differentiated state of beta cells and is a component of active enhancers in both murine and human islets.
CLIM interacts with estrogen receptor alpha (显示 ESR1 抗体) at the H19 (显示 NCKAP1 抗体) locus, potentially explaining the higher expression of H19 (显示 NCKAP1 抗体) in female than male corneas.
SSBP3 (显示 SSBP3 抗体) Interacts With Islet-1 (显示 ISL1 抗体) and Ldb1 to Impact Pancreatic beta-Cell Target Genes
the Isl1 (显示 ISL1 抗体)/Ldb1 complex orchestrates a network for heart-specific transcriptional regulation and coordination in three-dimensional space during cardiogenesis.
results indicate that LDB1-dependent looping events can deliver repressive cargo to cognate promoters to mediate promoter pausing events in a pituitary cell type
Alanine scanning mutagenesis of the LIM (显示 PDLIM5 抗体) interaction domain of LDB1 revealed a discrete motif, R(320)LITR, required for LMO2 (显示 LMO2 抗体) binding.
Clim2, in a complex with LMO4 (显示 LMO4 抗体), supports mammary stem cells by directly targeting the Fgfr2 (显示 FGFR2 抗体) promoter in basal cells to increase its expression
In t(8;21) leukemia cells, LDB1 functions as a component of the stable AML1 (显示 RUNX1 抗体)-ETO (显示 RUNX1T1 抗体)-containing transcription factor complex (AETFC). The AETFC components cooperatively regulate gene expression and contribute to leukemogenesis.
We investigated NLI (Ldb1 homolog) complex occupancy and chromatin conformation of the beta-globin (显示 HBB 抗体) locus in human erythroid cells.
These studies are consistent with a model in which TIF1gamma (显示 TRIM33 抗体) acts to ubiquitinate LDB1 leading to degradation of LDB1 and changes in transcription of LDB1-dependent promoters.
Expression of LDB1 (LIM-domain-binding 1) protein in which Lys134 is replaced with arginine leads to enhanced expression of the mutant protein compared with the wild-type protein.
1H, 15N and 13C assignments of FLIN4, an intramolecular LMO4 (显示 LMO4 抗体):ldb1 complex
Ssdp (显示 SSBP3 抗体) proteins interact with the LIM (显示 PDLIM5 抗体)-domain-binding protein Ldb1 to regulate development
Centrosome movements in vivo correlate with specific neurite formation downstream of LIM homeodomain transcription factor activity.
Study identifies a number of novel Ldb1 interacting proteins in murine erythroleukaemic cells, namely Eto-2 (显示 CBFA2T3 抗体), the cyclin-dependent kinase (显示 CDK1 抗体) Cdk9 (显示 CDK9 抗体), Lmo4 (显示 LMO4 抗体); morphilino-mediated knockdowns in zebrafish show these factors to be essential for haematopoiesis.
Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors.
, LIM domain-binding factor CLIM2
, LIM domain-binding protein 1
, carboxyl-terminal LIM domain-binding protein 2
, nuclear LIM interactor
, neural Src-interacting protein
, neural src interacting protein
, LIM domain-binding factor-1
, carboxy terminal LIM domain protein 2
, LIM-domain binding factor 1