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role of TRIB1 in cell cycle and survival that is mediated via the modulation of NFkappaB signaling.
the co-operativity observed between MYC (显示 MYC ELISA试剂盒) and TRIB1 in the absence of PML (显示 PML ELISA试剂盒)/RARA (显示 RARA ELISA试剂盒) show that, outside of acute promyelocytic leukemia (显示 PML ELISA试剂盒), gain of both genes may drive selection for trisomy 8.
The crucial role of TRIB1 in cisplatin-induced enrichment of CSC and drug resistance was verified by knockdown TRIB1. Interestingly, cisplatin treatment also contributed to the increasement of HDAC (显示 HDAC3 ELISA试剂盒), the interaction of TRIB1 with HDAC (显示 HDAC3 ELISA试剂盒), and inactivation of p53 (显示 TP53 ELISA试剂盒).
Trib1 formed a complex with pHDAC1.
Studies indicate that tribbles homolog 1 (Drosophila) protein appear to be involved in some of the most common diseases, such as cancer, metabolic disease and hyperlipidaemia.
Studies suggest that pseudo-kinase family of tribbles (TRIB) proteins TRIB1, TRIB2 (显示 TRIB2 ELISA试剂盒) and TRIB3 (显示 TRIB3 ELISA试剂盒) play roles in pathogenesis of rheumatoid arthritis (RA) and osteoarthritis.
Studies indicate that the minor allele of a single nucleotide polymorphism (SNP, rs6982502) in the regulatory sequence reduces the activity of the tribbles homolog 1 (Drosophila) protein (TRIB1) promoter.
Studies suggest that pseudo-kinase family of tribbles (TRIB) proteins TRIB1, TRIB2 (显示 TRIB2 ELISA试剂盒) and TRIB3 (显示 TRIB3 ELISA试剂盒) were involved in the pathogenesis of inflammation.
Studies indicate that tribbles homolog 1 (Drosophila) protein (TRIB1) interacts with the master molecule of Tregs, forkhead box P3 (FOXP3 (显示 FOXP3 ELISA试剂盒)), a transcription factor essential for Treg suppressive activity.
Studies indicate that tribbles homolog 1 (Drosophila) protein (tribbles-1; TRIB1) is an important modulator of human energy metabolism and metabolic syndromes.
The Liver Clock Controls Cholesterol Homeostasis through Trib1 Protein-mediated Regulation of PCSK9 (显示 PCSK9 ELISA试剂盒)/Low Density Lipoprotein Receptor (LDLR (显示 LDLR ELISA试剂盒)) Axis.
Deletion of hepatic Trib1 leads to increased C/EBPalpha (显示 CEBPA ELISA试剂盒) binding near upregulated lipogenic genes, as well as Trib1 itself.
TRIB1 and TRIB3 (显示 TRIB3 ELISA试剂盒) are more strongly expressed than TRIB2 (显示 TRIB2 ELISA试剂盒) in cumulus cells (CC) surrounding oocytes from preovulatory follicles than in CC of immature ones.
These data suggested that the modulation of TRIB1 expression affects hepatic lipogenesis and glycogenesis through multiple molecular interactions.
In gene knock-down experiments in macrophages using small interfering RNAs targeted to Trib1, it was observed that TNF-alpha (显示 TNF ELISA试剂盒) production was increased following treatment with IFN-gamma (显示 IFNG ELISA试剂盒) and/or TLR2 (显示 TLR2 ELISA试剂盒) ligands.
These results indicate that COP1 and Trib1 act as an oncoprotein complex functioning upstream of C/EBPalpha (显示 CEBPA ELISA试剂盒), and its ligase activity is crucial for leukemogenesis.
tribbles-1 is a novel binding partner of Foxp3 (显示 FOXP3 ELISA试剂盒) in regulatory T cells
results demonstrate that Trib1 is critical for adipose tissue maintenance and suppression of metabolic disorders by controlling the differentiation of tissue-resident M2-like macrophages
Trib1-knockout mice showed elevated levels of plasma TG and cholesterol due to increased VLDL production.
Trib1 transduced hematopoietic stem cells developed acute myeloid leukemia (显示 BCL11A ELISA试剂盒).
a nuclear factor\; gene expression induced by m1-acetylcholine receptor
tribbles homolog 1 (Drosophila)
, G-protein-coupled receptor induced protein
, phosphoprotein C8FW
, tribbles homolog 1
, G-protein-coupled receptor-induced gene 2 protein
, G-protein-coupled receptor-induced protein 2
, phosphoprotein regulated by mitogenic pathways
, tribbles-like protein 1
, G-protein-coupled receptor induced protein GIG2