电话:
400-7060-959
传真:
+86 10 56315212-8813
电子邮件:
orders@antibodies-online.cn

PLAU 蛋白

(Plasminogen Activator, Urokinase (PLAU))
This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009].
PLAU Protein (AA 21-431) (His tag) PLAU Protein (AA 21-431) (His tag) PLAU Protein (AA 21-431) (His tag) (ABIN7275455)

PLAU 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

PLAU Protein (AA 21-430) (His tag) PLAU Protein (AA 21-430) (His tag) PLAU Protein (AA 21-430) (His tag) (ABIN7275453)

PLAU 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

PLAU Protein (AA 21-431) (His-Avi Tag,Biotin) PLAU Protein (AA 21-431) (His-Avi Tag,Biotin) PLAU Protein (AA 21-431) (His-Avi Tag,Biotin) (ABIN7275460)

PLAU 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

PLAU 蛋白 by Grade

Find PLAU 蛋白 with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

PLAU 蛋白 by Origin

Find PLAU 蛋白 for a variety of species such as anti-Human PLAU, anti-Rat PLAU, anti-Chicken PLAU. The species listed below are among those available. Click on a link to go to the corresponding products.

PLAU 蛋白 by Source

Here you will find PLAU 蛋白 proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

PLAU 蛋白 by 蛋白类型

Here you can find PLAU 蛋白 proteins categorized by available protein types. Additional protein types can be located using our search function.

PLAU 蛋白 by 应用范围

Find PLAU 蛋白 validated for a specific application such as SDS, WB, ELISA, Imm. Some of the available applications are listed below. Click on a link to go to the corresponding products.

PLAU 蛋白 by 生物活性

Find PLAU 蛋白 with a specific 生物活性. The 生物活性 listed below are among those available. Click on a link to go to the corresponding products.

Popular PLAU 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (5)
Cat. No. ABIN7275455
Quantity 100 μg
Datasheet Datasheet
Reactivity Cynomolgus
Source HEK-293 Cells
Validations
  • (3)
Cat. No. ABIN7275453
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (3)
Cat. No. ABIN7275460
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7124470
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1315318
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3075302
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3075301
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3075303
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
Cat. No. ABIN7505721
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source HEK-293 Cells
Validations
Cat. No. ABIN7454200
Quantity 100 μg
Datasheet Datasheet
Reactivity Rat
Source HEK-293 Cells
Validations
Cat. No. ABIN7504511
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Human
Validations
Cat. No. ABIN7508085
Quantity 3 kU
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
Cat. No. ABIN7520393
Quantity 20 μg
Datasheet Datasheet
Reactivity Mouse
Source HEK-293 Cells
Validations
Cat. No. ABIN7454201
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7388882
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our PLAU 蛋白

Ambrosetti, Paoletti, Bosco, Parisse, Scaini, Tagliabue, de Marco, Casalis: "Quantification of Circulating Cancer Biomarkers via Sensitive Topographic Measurements on Single Binder Nanoarrays." in: ACS omega, Vol. 2, Issue 6, pp. 2618-2629, (2017) (PubMed).

Kim, Tirloni, Radulovic, Lewis, Bakshi, Hill, da Silva Vaz, Logullo, Termignoni, Mulenga: "Conserved Amblyomma americanum tick Serpin19, an inhibitor of blood clotting factors Xa and XIa, trypsin and plasmin, has anti-haemostatic functions." in: International journal for parasitology, Vol. 45, Issue 9-10, pp. 613-27, (2015) (PubMed).

Wu, Catano, Echeverry, Torre, Haile, An, Chen, Cheng, Nicholson, Tong, Park, Yepes: "Urokinase-type plasminogen activator promotes dendritic spine recovery and improves neurological outcome following ischemic stroke." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 43, pp. 14219-32, (2014) (PubMed).

Komissarov, Florova, Azghani, Karandashova, Kurdowska, Idell: "Active ?-macroglobulin is a reservoir for urokinase after fibrinolytic therapy in rabbits with tetracycline-induced pleural injury and in human pleural fluids." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 305, Issue 10, pp. L682-92, (2013) (PubMed).

Sanderson-Smith, Zhang, Ly, Donahue, Hollands, Nizet, Ranson, Ploplis, Walker, Castellino: "A key role for the urokinase plasminogen activator (uPA) in invasive Group A streptococcal infection." in: PLoS pathogens, Vol. 9, Issue 7, pp. e1003469, (2013) (PubMed).

Larusch, Merkulova, Mahdi, Shariat-Madar, Sitrin, Cines, Schmaier: "Domain 2 of uPAR regulates single-chain urokinase-mediated angiogenesis through ?1-integrin and VEGFR2." in: American journal of physiology. Heart and circulatory physiology, Vol. 305, Issue 3, pp. H305-20, (2013) (PubMed).

Ilkovitch, Carrio, Lopez: "uPA and uPA-receptor are involved in cancer-associated myeloid-derived suppressor cell accumulation." in: Anticancer research, Vol. 32, Issue 10, pp. 4263-70, (2012) (PubMed).

Botkjaer, Deryugina, Dupont, Gårdsvoll, Bekes, Thuesen, Chen, Chen, Ploug, Quigley, Andreasen: "Targeting tumor cell invasion and dissemination in vivo by an aptamer that inhibits urokinase-type plasminogen activator through a novel multifunctional mechanism." in: Molecular cancer research : MCR, Vol. 10, Issue 12, pp. 1532-43, (2012) (PubMed).

Novak, Bryer, Cheng, Nguyen, Conley, Cunningham, Xue, Sisson, You, Hornberger, Koh: "Macrophage-specific expression of urokinase-type plasminogen activator promotes skeletal muscle regeneration." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 187, Issue 3, pp. 1448-57, (2011) (PubMed).

Hosseini, Jiang, Sørensen, Jensen, Christensen, Fogh, Yuan, Andersen, Huang, Andreasen, Jensen: "Elucidation of the contribution of active site and exosite interactions to affinity and specificity of peptidylic serine protease inhibitors using non-natural arginine analogs." in: Molecular pharmacology, Vol. 80, Issue 4, pp. 585-97, (2011) (PubMed).

Aliases for PLAU 蛋白

plasminogen activator, urokinase (PLAU) 蛋白
urokinase-type plasminogen activator (CpipJ_CPIJ002131) 蛋白
urokinase-type plasminogen activator (CpipJ_CPIJ006543) 蛋白
urokinase-type plasminogen activator (CpipJ_CPIJ013396) 蛋白
urokinase-type plasminogen activator (CpipJ_CPIJ013623) 蛋白
plasminogen activator, urokinase (Plau) 蛋白
ATF 蛋白
BDPLT5 蛋白
PLAU 蛋白
QPD 蛋白
u-PA 蛋白
UPA 蛋白
uPA 蛋白
UPAM 蛋白
URK 蛋白
You are here:
客服