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Gene expression level of NRD1 is significantly higher in AD patients when compared to normal controls.
MRNA expression of NRD1 was upregulated in 56% of ESCC tissue samples.
This study demonistrated that alcohol-dependent reduction of nardilysin in cell culture and nervous tissue points to an implication of the enzyme in the pathophysiology of alcoholism.
possible roles of nardilysin in Alzheimer disease, Down syndrome, schizophrenia, mood disorders, alcohol abuse, heroin addiction and cancer; show that nardilysin is a Janus-faced enzyme with regard to brain pathology-- probably neuropathogenic in some diseases, but neuroprotective in others [review]
SH-SY5Y cells, stably transfected with green fluorescent protein-tagged-p42 (显示 EPB42 ELISA试剂盒)(IP4) show enhanced NRD (显示 PRDM1 ELISA试剂盒) protein expression already at an earlier time point after retinoic acid stimulation.
NRD1 interacts with p53 (显示 TP53 ELISA试剂盒) mutant R273H
These results demonstrate that gastric cancer cell growth is maintained by autonomous TNF-alpha (显示 TNF ELISA试剂盒)-NF-kappaB (显示 NFKB1 ELISA试剂盒) and IL-6 (显示 IL6 ELISA试剂盒)-STAT3 (显示 STAT3 ELISA试剂盒) signalling, and that NRDc and ADAM proteases turn on these signalling cascades by stimulating ectodomain shedding of TNF-alpha (显示 TNF ELISA试剂盒).
Identification and characterization of nardilysin as a novel dimethyl H3K4-binding protein involved in transcriptional regulation.
Several flanking SNPs of the top hits in the meta-analysis demonstrated borderline associations with alcohol dependence in the family sample for KIAA0040, NRD1 and THSD7B, respectively.
Tubulin (显示 TUBB ELISA试剂盒) potentiates the interaction of the metalloendopeptidase (显示 THOP1 ELISA试剂盒) nardilysin with the neuronal scaffold protein (显示 HOMER1 ELISA试剂盒) p42IP4 (显示 ADAP1 ELISA试剂盒)/centaurin-alpha1 (ADAP1 (显示 ADAP1 ELISA试剂盒)).
Nardilysin Is Required for Maintaining Pancreatic beta-Cell Function
deletion of nardilysin prevents the development of diet-induced steatohepatitis and liver fibrogenesis
The use of proteolysis to study the structure of nardilysin.
Studies extend the range of potential substrates for nardilysin and further substantiate that nardilysin is a true peptidase.
miniglucagon-generating endopeptidase is composed of NRDc and aminopeptidase B (显示 RNPEP ELISA试剂盒) acting sequentially
role for nardilysin in oocyte meiosis through its dynamic translocation from cytosol to nucleus, and then to the spindle apparatus
NRDc regulates axonal maturation and myelination in the nervous system, in part, through the modulation of NRG1 (显示 NRG1 ELISA试剂盒) shedding
The acidic stretch of nardilysin, expressed as a fusion protein with glutathione S-transferase (显示 GSTa2 ELISA试剂盒) and compared to the native enzyme with respect to spermine binding, functions as an autonomous domain.
This gene encodes a zinc-dependent endopeptidase that cleaves peptide substrates at the N-terminus of arginine residues in dibasic moieties and is a member of the peptidase M16 family. This protein interacts with heparin-binding EGF-like growth factor and plays a role in cell migration and proliferation. Multiple transcript variants encoding different isoforms have been found for this gene.
, N-arginine dibasic convertase 1
, nardilysin 1 (N-arginine dibasic convertase)
, nardilysin, N-arginine dibasic convertase 1
, nardilysin, N-arginine dibasic convertase, NRD convertase 1
, N-arginine dibasic convertase
, nardilysin (N-arginine dibasic convertase)
, Nardilysin-like protein