Mitofusin 2 (MFN2) ELISA试剂盒产品概述

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Mitofusin 2 ELISA试剂盒 (MFN2)
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anon-WO0125274.3, CG3869, CMT2A, CMT2A2, CPRP1, D630023P19Rik, Dmel\\CG3869, dmfn, Fzo, HSG, marf, Marf-1, mfn, MFN2, mg:cb01g09, si:dkeyp-104h9.2, wu:fb79a11

Mitofusin 2 (MFN2) ELISA试剂盒 by Reactivity

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适于 Mitofusin 2 相互作用对的更多 ELISA 试剂盒

Fruit Fly (Drosophila melanogaster) Mitofusin 2 (MFN2) interaction partners

  1. activation of endoplasmic reticulum stress by defective mitochondria is neurotoxic in pink1 and parkin (显示 PARK2 ELISA试剂盒) flies and that the reduction of this signalling is neuroprotective, independently of defective mitochondria.

  2. Clu (显示 CLU ELISA试剂盒) is upstream of and binds to VCP (显示 vcp ELISA试剂盒) in vivo and promotes VCP (显示 vcp ELISA试剂盒)-dependent Marf degradation in vitro Marf accumulates in whole muscle lysates of clu (显示 CLU ELISA试剂盒)-deficient flies and is destabilized upon Clu (显示 CLU ELISA试剂盒) overexpression. Thus, Clu (显示 CLU ELISA试剂盒) is essential for mitochondrial homeostasis and functions in concert with Parkin (显示 PARK2 ELISA试剂盒) and VCP (显示 vcp ELISA试剂盒) for Marf degradation to promote damaged mitochondrial clearance.

  3. lack of ChChd3 leads to inactivation of Hippo activity under normal development, which is also dependent on the transcriptional coactivator Yorkie (Yki (显示 YAP1 ELISA试剂盒)). Furthermore, loss of ChChd3 induces oxidative stress and activates the JNK (显示 MAPK8 ELISA试剂盒) pathway. In addition, depletion of other mitochondrial fusion components, Opa1 (显示 OPA1 ELISA试剂盒) or Marf, inactivates the Hippo pathway as well.

  4. Marf is required for mitochondrial fusion and transport in long axons.

  5. Expression of Mfn2 and endoplasmic reticulum (ER) stress reduction in flies lacking Marf corrected ER shape, attenuating the developmental and motor defects.

  6. Parkin (显示 PARK2 ELISA试剂盒) deficiency and resulting mitophagic disruption produces cardiomyopathy which can be contained by suppressing mitofusin.

  7. mfn2 mutations alter mitochondrial dynamics and induce retinal and cardiac pathology

  8. Data report here that Drosophila Reaper can induce mitochondrial fragmentation by binding to and inhibiting the pro-fusion protein MFN2 and its Drosophila counterpart dMFN/Marf.

  9. MARF and Opa1 (显示 OPA1 ELISA试剂盒) control mitochondrial and cardiac function in Drosophila.

  10. The PINK1/Parkin (显示 PARK2 ELISA试剂盒) pathway affects mitochondrial fission/fusion as suggested by previous genetic interaction studies.

Human Mitofusin 2 (MFN2) interaction partners

  1. MFN2 gene polymorphisms (rs873457, rs2336384, rs1474868, rs4846085 and rs2236055) may be associated with acute liver failure and the rs873457 and rs4846085 polymorphisms are correlated with the risk and prognosis of acute liver failure.

  2. SLC25A46 (显示 SLC25A46 ELISA试剂盒) is a new component in mitochondrial dynamics that serves as a regulator for MFN1 (显示 MFN1 ELISA试剂盒)/2 oligomerization.

  3. Presenilin 2 (PS2 (显示 PSEN2 ELISA试剂盒)), mutations in which underlie familial Alzheimer's disease (FAD (显示 BRCA2 ELISA试剂盒)), promotes endoplasmic reticulum-mitochondria coupling only in the presence of mitofusin 2 (Mfn2).

  4. PGC-1alpha (显示 PPARGC1A ELISA试剂盒) enhances Mfn2 transcription, but also leads to increased degradation of the Mfn2 protein, a key ubiquitylation target of Parkin (显示 PARK2 ELISA试剂盒) on mitochondria. In vivo, Parkin (显示 PARK2 ELISA试剂盒) has significant protective effects on the survival and function of nigral dopaminergic neurons in which the chronic expression of PGC-1alpha (显示 PPARGC1A ELISA试剂盒) is induced

  5. Exome sequencing identified MFN2 SNVs in two of the individuals. Neuropathy-associated CNV outside of the PMP22 (显示 PMP22 ELISA试剂盒) locus is rare in Charcot-Marie-Tooth (CMT) disease . Nevertheless, there is potential clinical utility in testing for CNVs and exome sequencing in CMT cases negative for the CMT1A (显示 PMP22 ELISA试剂盒) duplication.

  6. Smad2 (显示 SMAD2 ELISA试剂盒) is a key scaffold, allowing RIN1 (显示 RIN1 ELISA试剂盒) to act as a GTP (显示 AK3 ELISA试剂盒) exchange factor for MFN2-GTPase (显示 RACGAP1 ELISA试剂盒) activation to promote mitochondrial ATP synthesis and suppress superoxide production during mitochondrial fusion.

  7. our results suggest that KAP1 (显示 CDKN3 ELISA试剂盒) Ser473 phosphorylation acts through MFN2 reduction to restrict mitochondrial hyperfusion, thereby contributing to cancer cell survival under conditions of sustained metabolic stress

  8. Mfn2 downregulation or the exogenous expression of normal Parkin (显示 PARK2 ELISA试剂盒) restored cytosolic Ca(2 (显示 CA2 ELISA试剂盒)+) transients in fibroblasts from patients with PARK2 (显示 PARK2 ELISA试剂盒) mutations, a catalytically inactive Parkinson's disease (PD)-related Parkin (显示 PARK2 ELISA试剂盒) variant had no effect. Parkin (显示 PARK2 ELISA试剂盒) is directly involved in regulating ER-mitochondria contacts and provide new insight into the role of the loss of Parkin (显示 PARK2 ELISA试剂盒) function in PD development

  9. siRNA knockdown of mitofusin-2 (Mfn2), a protein that is involved in the tethering of endoplasmic reticulum and mitochondria, leads to increased contact between the two organelles.

  10. Taken together, these data suggest that the striking reduction in mitochondria in MNs (显示 FLNA ELISA试剂盒) expressing mutant MFN2 is not the result of impaired biogenesis, but more likely the consequence of enhanced mitophagy.

Mouse (Murine) Mitofusin 2 (MFN2) interaction partners

  1. Presenilin 2 (PS2 (显示 PSEN2 ELISA试剂盒)), mutations in which underlie familial Alzheimer's disease (FAD (显示 FANCD2 ELISA试剂盒)), promotes endoplasmic reticulum-mitochondria coupling only in the presence of mitofusin 2 (Mfn2).

  2. The data of this study suggest that post-translational modification of Mfn2 is associated with its dysregulation during a window of metabolic vulnerability that precedes glaucomatous degeneration.

  3. Study demonstrated that deregulation of mfn2 played a critical role in the mitochondrial disorder during the progression of Alzheimer's disease, and its decreased expression was regulated at least in part by miR (显示 MLXIP ELISA试剂盒)-195. Therefore, upregulation of mfn2 expression by decreasing the level of miR (显示 MLXIP ELISA试剂盒)-195 might be a potential new therapeutic strategy for treatment of Alzheimer's disease.

  4. Mfn2 downregulation or the exogenous expression of normal Parkin (显示 PARK2 ELISA试剂盒) restored cytosolic Ca(2 (显示 CA2 ELISA试剂盒)+) transients in fibroblasts from patients with PARK2 (显示 PARK2 ELISA试剂盒) mutations, a catalytically inactive Parkinson's disease (PD)-related Parkin (显示 PARK2 ELISA试剂盒) variant had no effect. Parkin (显示 PARK2 ELISA试剂盒) is directly involved in regulating ER-mitochondria contacts and provide new insight into the role of the loss of Parkin (显示 PARK2 ELISA试剂盒) function in PD development.

  5. Altogether, these results demonstrate that Mfn2 is a mediator of mitochondria to lipid droplet interactions, influencing lipolytic processes and whole-body energy homeostasis.

  6. we demonstrated that by modulating mitochondrial energy metabolism through Mfn2 and mitochondrial Ca2 (显示 CA2 ELISA试剂盒)+, PPAR-b (显示 PPARD ELISA试剂盒) took an important role in neuronal differentiation induced by flavonoid compound 4a

  7. Furthermore, analysis of muscle Mfn2-deficient mice revealed that aging-induced Mfn2 decrease underlies the age-related alterations in metabolic homeostasis and sarcopenia.

  8. Mice hemizygous for a pathogenic Mfn2 allele exhibit hind limb/foot gait deficits and phenotypic perturbations in nerve and muscle.

  9. We found that mouse embryonic fibroblasts lacking Mfn2 have altered lipid droplet morphology. However, triacylglycerol biosynthesis was not dependent on ER-mitochondrial tethering mediated by mitofusins. Lastly, Mfn2 does not have a role in adipocyte differentiation.

  10. knockdown of Mfn2 in adipo and osteogenesis and the overexpression of a dominant negative form of Drp1 (显示 CRMP1 ELISA试剂盒) during chondrogenesis resulted in a loss of differentiation ability

Zebrafish Mitofusin 2 (MFN2) interaction partners

  1. These results highlight the essential role of mitofusin 2 in the motor axon development and demonstrate the potential of zebrafish as a suitable and complementary platform for dissecting pathogenetic mechanisms of MFN2 mutations in vivo.

Cow (Bovine) Mitofusin 2 (MFN2) interaction partners

  1. A highly unusual splicing defect, where an exonic single base exchange leads to the retention of the preceding intron, was identified in MFN2 (显示 MFN1 ELISA试剂盒).

Mitofusin 2 (MFN2) 抗原简介

Antigen Summary

This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified.

Alternative names and synonyms associated with Mitofusin 2 (MFN2)

  • mitofusin 2 (MFN2) Elisa Kit
  • Mitochondrial assembly regulatory factor (Marf) Elisa Kit
  • mitofusin 2 (mfn2) Elisa Kit
  • mitofusin 2 (Mfn2) Elisa Kit
  • mitofusin 2 (LOC100350119) Elisa Kit
  • anon-WO0125274.3 Elisa Kit
  • CG3869 Elisa Kit
  • CMT2A Elisa Kit
  • CMT2A2 Elisa Kit
  • CPRP1 Elisa Kit
  • D630023P19Rik Elisa Kit
  • Dmel\\CG3869 Elisa Kit
  • dmfn Elisa Kit
  • Fzo Elisa Kit
  • HSG Elisa Kit
  • marf Elisa Kit
  • Marf-1 Elisa Kit
  • mfn Elisa Kit
  • MFN2 Elisa Kit
  • mg:cb01g09 Elisa Kit
  • si:dkeyp-104h9.2 Elisa Kit
  • wu:fb79a11 Elisa Kit

Protein level used designations for Mitofusin 2 (MFN2) ELISA试剂盒

CG3869-PA , CG3869-PB , CG3869-PC , Marf-PA , Marf-PB , Marf-PC , drosophila mitofusin , mitochondrial assembly regulatory factor , mitofusin , mitofusin 2 , mitofusin-2 , mitofusin-2-like , hyperplasia suppressor , transmembrane GTPase MFN2 , HSG protein , hypertension related protein 1 , hypertension-related protein 1 , hypertension-related protein , mitochondrial transmembrane GTPase FZO1A

GENE ID SPECIES
100055966 Equus caballus
31581 Drosophila melanogaster
457958 Pan troglodytes
549268 Xenopus (Silurana) tropicalis
100172672 Pongo abelii
100186475 Ciona intestinalis
100427191 Macaca mulatta
100470367 Ailuropoda melanoleuca
100599174 Nomascus leucogenys
9927 Homo sapiens
170731 Mus musculus
64476 Rattus norvegicus
567448 Danio rerio
431918 Xenopus laevis
419484 Gallus gallus
487439 Canis lupus familiaris
534574 Bos taurus
100350119 Oryctolagus cuniculus
100512172 Sus scrofa
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