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VHL 蛋白

(Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL))
Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].
VHL Protein (AA 1-172) (GST tag) VHL Protein (AA 1-172) (GST tag) VHL Protein (AA 1-172) (GST tag) (ABIN1325000)

VHL 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP

VHL Protein (AA 1-213) (Strep Tag) VHL Protein (AA 1-213) (Strep Tag) VHL Protein (AA 1-213) (Strep Tag) (ABIN3075417)

Crystallography grade VHL 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA

VHL Protein (AA 1-213) (His tag) (ABIN7424887)

VHL 宿主: 人 宿主: 大肠杆菌(E. Coli) Recombinant > 80 % WB, SDS, Imm, PC

VHL 蛋白 by Grade

Find VHL 蛋白 with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

VHL 蛋白 by Origin

Find VHL 蛋白 for a variety of species such as anti-Human VHL, anti-Dog VHL, anti-Rat VHL. The species listed below are among those available. Click on a link to go to the corresponding products.

VHL 蛋白 by Source

Here you will find VHL 蛋白 proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

VHL 蛋白 by 蛋白类型

Here you can find VHL 蛋白 proteins categorized by available protein types. Additional protein types can be located using our search function.

VHL 蛋白 by 应用范围

Find VHL 蛋白 validated for a specific application such as WB, ELISA, SDS, Imm. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Popular VHL 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
Cat. No. ABIN1325000
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
  • (1)
Cat. No. ABIN3075417
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7424887
Quantity 100 μg
Datasheet Datasheet
Reactivity Rat
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7409467
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2735257
Quantity 20 μg
Datasheet Datasheet
Reactivity Dog
Source Yeast
Validations
Cat. No. ABIN1634750
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our VHL 蛋白

Kim, Lee, Jang, Yi, Kim, Han, Lee, Tong, Vincelette, Gao, Yin, Evans, Choi, Qin, Liu, Zhang, Deng, Jen, Zhang, Wang, Lou: "WSB1 promotes tumor metastasis by inducing pVHL degradation." in: Genes & development, Vol. 29, Issue 21, pp. 2244-57, (2015) (PubMed).

Aliases for VHL 蛋白

von Hippel-Lindau tumor suppressor (VHL) 蛋白
von Hippel-Lindau (Vhl) 蛋白
von Hippel-Lindau tumor suppressor (vhl) 蛋白
von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase (VHL) 蛋白
von Hippel-Lindau disease tumor suppressor (CpipJ_CPIJ009992) 蛋白
von Hippel-Lindau tumor suppressor (Vhl) 蛋白
BcDNA:RH61560 蛋白
CG13221 蛋白
d-VHL 蛋白
d-vhl 蛋白
Dmel\\CG13221 蛋白
dmVHL 蛋白
DVhl 蛋白
Dvhl 蛋白
dVHL 蛋白
HRCA1 蛋白
hrca1 蛋白
pVHL 蛋白
RCA1 蛋白
rca1 蛋白
VHL 蛋白
vhl 蛋白
VHL1 蛋白
vhl1 蛋白
Vhlh 蛋白
zgc:158722 蛋白
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