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VHL 抗体

(Von Hippel-Lindau Tumor Suppressor, E3 Ubiquitin Protein Ligase (VHL))
Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].
VHL 抗体  (AA 1-172) VHL 抗体  (AA 1-172) VHL 抗体 (AA 1-172) (ABIN3020968)

VHL 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

VHL 抗体 VHL 抗体 VHL 抗体 (ABIN2854928)

VHL 适用: 人 WB, IF, IHC (p), IP, ICC 宿主: 兔 Polyclonal unconjugated

VHL 抗体 VHL 抗体 VHL 抗体 (ABIN1501712)

VHL 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 1E1 unconjugated

VHL 抗体 by Grade

Find VHL 抗体 with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

VHL 抗体 by 适用

Find VHL 抗体 for a variety of species such as anti-Human VHL, anti-Mouse VHL, anti-Rat VHL. The species listed below are among those available. Click on a link to go to the corresponding products.

VHL 抗体 by 应用范围

Find VHL 抗体 validated for a specific application such as WB, ELISA, IF (cc), IF (p). Some of the available applications are listed below. Click on a link to go to the corresponding products.

VHL 抗体 by 抗体来源

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VHL 抗体 by 抗原表位

Find VHL 抗体 with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.

VHL 抗体 by 克隆形成能力

Find available monoclonal or polyclonal VHL 抗体. Click on a link to go to the corresponding products.

VHL 抗体 by 克隆

Find VHL 抗体 with a specific 克隆. The 克隆 listed below are among those available. Click on a link to go to the corresponding products.

VHL 抗体 by 标记

Find VHL 抗体 with a specific conjugate such as Biotin, Alexa Fluor 488, Alexa Fluor 555. The conjugates listed below are among those available. Click on a link to go to the corresponding products.

Popular VHL 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IF
Validations
  • (3)
  • (6)
Cat. No. ABIN3020968
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF, IHC (p), IP, ICC
Validations
  • (1)
  • (8)
Cat. No. ABIN2854928
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IHC (p)
Validations
  • (8)
Cat. No. ABIN1501712
Quantity 100 μL
Datasheet Datasheet
Reactivity Rat
Application WB, IHC, IP, ICC
Validations
  • (5)
Cat. No. ABIN7441592
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, FACS, IF, IHC (p)
Validations
  • (7)
Cat. No. ABIN390462
Quantity 200 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, IHC, ELISA, FACS, IF
Validations
  • (6)
Cat. No. ABIN3029605
Quantity 0.2 mL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IF
Validations
  • (4)
Cat. No. ABIN563371
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IHC, IF
Validations
  • (4)
Cat. No. ABIN7254899
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application WB, FACS, IHC (p)
Validations
  • (2)
  • (4)
Cat. No. ABIN390463
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, ELISA, FACS
Validations
  • (5)
Cat. No. ABIN3029606
Quantity 0.4 mL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IF, ICC
Validations
  • (1)
  • (2)
Cat. No. ABIN532934
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC, ELISA
Validations
  • (3)
Cat. No. ABIN185675
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application IHC, ELISA
Validations
  • (2)
Cat. No. ABIN7189407
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application IHC, ELISA
Validations
  • (2)
Cat. No. ABIN7235662
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (2)
Cat. No. ABIN521328
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our VHL 抗体

Li, Qu, Jin, Guo, Wang, Qi, Yang, Zhang, Li: "Protective effect of salidroside against bone loss via hypoxia-inducible factor-1α pathway-induced angiogenesis." in: Scientific reports, Vol. 6, pp. 32131, (2018) (PubMed).

Gao, Wu, Xie, Li, Mao, Duan, Han, Han, Yu, Lu, Yang, Xu, Xia, Chen, Wang: "VHL deficiency augments anthracycline sensitivity of clear cell renal cell carcinomas by down-regulating ALDH2." in: Nature communications, Vol. 8, pp. 15337, (2018) (PubMed).

Guo, Qi, Yang, Wang, Wang, Li, Li, Qu, Wang, Han: "Salidroside accelerates fracture healing through cell-autonomous and non-autonomous effects on osteoblasts." in: Cell and tissue research, Vol. 367, Issue 2, pp. 197-211, (2017) (PubMed).

Liu, Cai, Hu, Mei, Zhang, Ouyang, Wang, Zhang, Xiao: "Forkhead Transcription Factor 3a (FOXO3a) Modulates Hypoxia Signaling via Up-regulation of the von Hippel-Lindau Gene (VHL)." in: The Journal of biological chemistry, Vol. 291, Issue 49, pp. 25692-25705, (2017) (PubMed).

Lee, Frattini, Bansal, Castano, Sherman, Hutchinson, Bruce, Califano, Liu, Cardozo, Iavarone, Lasorella: "An ID2-dependent mechanism for VHL inactivation in cancer." in: Nature, Vol. 529, Issue 7585, pp. 172-7, (2016) (PubMed).

Alahari, Post, Caniggia: "Jumonji Domain Containing Protein 6: A Novel Oxygen Sensor in the Human Placenta." in: Endocrinology, Vol. 156, Issue 8, pp. 3012-25, (2015) (PubMed).

Shao, Zhang, Yang, Qi, Zhang, Deng: "HIF-1α disturbs osteoblasts and osteoclasts coupling in bone remodeling by up-regulating OPG expression." in: In vitro cellular & developmental biology. Animal, Vol. 51, Issue 8, pp. 808-14, (2015) (PubMed).

Du, Zhang, Zhang, Ouyang, Wang, Liu, Li, Ji, Liu, Xiao: "pVHL Negatively Regulates Antiviral Signaling by Targeting MAVS for Proteasomal Degradation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 195, Issue 4, pp. 1782-90, (2015) (PubMed).

Wang, Zhang, Ji, Liu, Ouyang, Xiao: "The von hippel-lindau protein suppresses androgen receptor activity." in: Molecular endocrinology (Baltimore, Md.), Vol. 28, Issue 2, pp. 239-48, (2015) (PubMed).

Xi, Gao, Han, Li, Feng, Zhang, Ji, Xiao, Zhang, Wei: "Hypoxia inducible factor-1α suppresses Peroxiredoxin 3 expression to promote proliferation of CCRCC cells." in: FEBS letters, Vol. 588, Issue 18, pp. 3390-4, (2014) (PubMed).

Aliases for VHL 抗体

von Hippel-Lindau tumor suppressor (VHL) 抗体
von Hippel-Lindau (Vhl) 抗体
von Hippel-Lindau tumor suppressor (vhl) 抗体
von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase (VHL) 抗体
von Hippel-Lindau disease tumor suppressor (CpipJ_CPIJ009992) 抗体
von Hippel-Lindau tumor suppressor (Vhl) 抗体
BcDNA:RH61560 抗体
CG13221 抗体
d-VHL 抗体
d-vhl 抗体
Dmel\\CG13221 抗体
dmVHL 抗体
DVhl 抗体
Dvhl 抗体
dVHL 抗体
HRCA1 抗体
hrca1 抗体
pVHL 抗体
RCA1 抗体
rca1 抗体
VHL 抗体
vhl 抗体
VHL1 抗体
vhl1 抗体
Vhlh 抗体
zgc:158722 抗体
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