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Human VEGFR2 ELISA Kit for Sandwich ELISA - ABIN625109
Navid, Baker, McCarville, Stewart, Billups, Wu, Davidoff, Spunt, Furman, McGregor, Hu, Panetta, Turner, Fofana, Reddick, Leung, Santana: Phase I and clinical pharmacology study of bevacizumab, sorafenib, and low-dose cyclophosphamide in children and young adults with refractory/recurrent solid tumors. in Clinical cancer research : an official journal of the American Association for Cancer Research 2013
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Human VEGFR2 ELISA Kit for Sandwich ELISA - ABIN414630
Nassehi, Sørensen, Dyrbye, Thomsen, Juhler, Laursen, Broholm: Peritumoral brain edema in angiomatous supratentorial meningiomas: an investigation of the vascular endothelial growth factor A pathway. in APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2013
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Human VEGFR2 ELISA Kit for Sandwich ELISA - ABIN1672753
Li, Huang, Chen, Chen, Xiong, Chen, You, Jin, Liang: Oriented immobilization of anti-CD34 antibody on titanium surface for self-endothelialization induction. in Journal of biomedical materials research. Part A 2010
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Human VEGFR2 ELISA Kit for Sandwich ELISA - ABIN365817
Du, Wang, Ren, Lv, He: Revealing multi-binding sites for taspine to VEGFR-2 by cell membrane chromatography zonal elution. in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2012
These results indicate that VEGF-C (显示 VEGFC ELISA试剂盒)-induced MSC (显示 MSC ELISA试剂盒) osteogenesis is mediated through VEGFR2 and VEGFR3 (显示 FLT4 ELISA试剂盒), and followed the activation of the ERK (显示 MAPK1 ELISA试剂盒)/RUNX2 (显示 RUNX2 ELISA试剂盒) signaling pathway.
found that WT1 (显示 WT1 ELISA试剂盒) and KDR are co-expressed in Sertoli cells of the testes and somatic cells of embryonic ovaries. Furthermore, WT1 (显示 WT1 ELISA试剂盒) bound to the Kdr promoter in the chromatin of embryonic testes and ovaries. KDR signaling represses the testis-promoting gene Sox9 (显示 SOX9 ELISA试剂盒) in embryonic XX gonads
This is the first report demonstrating the spatiotemporal expression patterns of Flk1 and Flt1 (显示 FLT1 ELISA试剂盒) in the coronary vascular system during development and after MI; thus, this study suggests that these factors have distinct and important functions in coronary angiogenesis.
VEGFR2-associated alpha(2,6)-linked sialic acid plays an important role in modulating VEGF (显示 VEGFA ELISA试剂盒)/VEGFR2 interaction, EC pro-angiogenic activation and neovessel formation.
These results revealed that vascular sprouting and permeability are both controlled through the VEGFR2-TSAd-c-Src signaling pathway in a subset of tissues, which may be useful in developing strategies to control tissue-specific pathological angiogenesis.
Data show that editing of genomic VEGFR2 locus using rAAV1-mediated CRISPR/Cas9 abrogates angiogenesis in the mouse models of oxygen-induced retinopathy and laser-induced choroid neovascularization.
Our study demonstrates that Prox1-GFP/Flk1::myr-mCherry mice are a useful model for studying coordinated hemangiogenic and lymphangiogenic responses
Endoglin (显示 ENG ELISA试剂盒) prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 signalling
CLEC14A (显示 CLEC14A ELISA试剂盒) acts in vascular homeostasis by fine-tuning VEGFR-2 and VEGFR-3 (显示 FLT4 ELISA试剂盒) signaling in endothelial cells
The elevated soluble VEGFR-2 that was found in the aortas of apoE (显示 APOE ELISA试剂盒)(-/-) mice with atherosclerosis binds to and diminishes the activity of VEGF-C (显示 VEGFC ELISA试剂盒).
Data show that Leishmania major infection initiates enhanced vascular endothelial growth factor-A (显示 VEGFA ELISA试剂盒)/VEGFR-2 signaling and suggest that VEGFR-2-dependent lymphangiogenesis is a mechanism that restricts tissue inflammation in leishmaniasis.
Data indicate that simultaneous targeting of molecules that control distinct phases of angiogenesis, such as ALK1 and VEGFR, is a valid strategy for treatment of metastatic renal cell carcinoma (mRCC).
Primary cultures derived from melanomas harboring the KDR variant were more proliferative and invasive than KDR wild type.
this study of cabozantinib (a dual VEGFR2/MET) in metastatic TNBC, while not meeting its prespecified endpoint, showed that treatment is associated with circulating biomarker changes, and is active in a subset of patients.
The efficacy and safety of VEGFR-TKIs after PD-1 (显示 PDCD1 ELISA试剂盒) inhibition were demonstrated in this retrospective study. The response rate was lower and the median progression-free survival was shorter in those patients who received prior PD-1 (显示 PDCD1 ELISA试剂盒) in combination with VEGFR-TKI. PD-1 (显示 PDCD1 ELISA试剂盒) exposure does not seem to significantly influence the safety of subsequent VEGFR-TKI treatment
FGD5 regulates VEGFR2 retention in recycling endosomes and coupling to PI3 (显示 PI3 ELISA试剂盒) (phosphoinositide-3) kinase/mTORC2 (显示 CRTC2 ELISA试剂盒)-dependent cytoskeletal remodeling in endothelial cells.
Results indicate that ranibizumab affects the VEGF-A (显示 VEGFA ELISA试剂盒) metabolism in RPE cells from an extra- as well as intracellular site. The drug is taken up into the cells, with the VEGF receptor 2 (VEGFR-2) being involved, and decreases VEGF-A (显示 VEGFA ELISA试剂盒) protein levels within the cells as well as extracellularly.
Danggui-Sayuk-Ga-Osuyu-Saenggang-Tang (DSGOST) inhibits angiogenic signaling by blocking VEGF (显示 VEGFA ELISA试剂盒) binding to VEGFR2.
Data show that anti-VEGFR2 (vascular endothelial growth factor receptor 2) antibody (mAb04) of fusion protein (mAb04-MICA (显示 MICA ELISA试剂盒)) enhanced immunosurveillance activated by the NKG2D (显示 KLRK1 ELISA试剂盒) pathway.
this study found no difference in VEGFR2 expression in infantile hemangiomas from the study and control group
Here we demonstrate that VEGF (显示 VEGFA ELISA试剂盒)-165 mediates MSC (显示 MSC ELISA试剂盒) differentiation into ECs via VEGFR-2-dependent induction of Sox18 (显示 SOX18 ELISA试剂盒), which ultimately coordinates the transcriptional upregulation of specific markers of the EC phenotype
NOS (显示 NOS ELISA试剂盒) stimulation via PI3K, calpain proteases, and SIRT1 (显示 SIRT1 ELISA试剂盒)-dependent deacetylation downstream from VEGFR2 activation contributes to these vasodilator responses.
we analyzed the expression and cellular distribution of Flt-1(VEGFR-1 (显示 FLT1 ELISA试剂盒)) and Flk-1 (KDR/VEGFR-2)in newborn piglet brain
expression of FLK1, CD146 (显示 MCAM ELISA试剂盒) and microvessel density of angiogenesis at the first week of reperfused acute myocardial infarction.
VEGF (显示 VEGFA ELISA试剂盒) supplementation at the late embryonic developmental stage might improve the developmental potential of both IVF (显示 SCN5A ELISA试剂盒) and somatic nuclear transfer preimplantation porcine embryos through its receptors.
The VEGFR2 mRNA was only upregulated in early glomerulogenesis, suggesting that VEGFR2 is important for the vascular growth.
increased placental expression of the VEGF receptor (显示 FLT1 ELISA试剂盒) system is associated with increased placental vascular density observed with the advancement of gestation in the pig
VEGF ligand-receptor system may play an important role in the development and maintenance of the corpus luteum in pigs.
VEGF (显示 VEGFA ELISA试剂盒)/Flk-1/Flt-1 (显示 FLT1 ELISA试剂盒) system is activated during myocardial ischemia reperfusion injury.
Hemodialysis graft placement leads to early increases in wall shear stress, VEGF-A (显示 VEGFA ELISA试剂盒), pro-MMP-9 (显示 MMP9 ELISA试剂盒), MMP-2 (显示 MMP2 ELISA试剂盒), VEGFR-1 (显示 FLT1 ELISA试剂盒), VEGFR-2, and TIMP-1 (显示 TIMP1 ELISA试剂盒), which may contribute to the development of venous stenosis.
data for the first time demonstrate a calpain/PTP1B/VEGFR2 negative feedback loop in the regulation of VEGF-induced angiogenesis. Modulation of local PTP1B and/or calpain activities may prove beneficial in the treatment of impaired wound healing in diabetes.
endothelial cells exposed to TGF-beta1 (显示 TGFB1 ELISA试剂盒) lose both tip and stalk cell identity, possibly mediated by loss of VEGFR2 signaling.
These results suggest that non-dominant follicles maintain a greater concentration of the mRNA expression of both membrane and soluble VEGF receptors; but follicular dominance is related to a reduction in the mRNA expression of sVEGFR1 and sVEGFR2.
Data suggest that galectin-1 (显示 LGALS1 ELISA试剂盒) and VEGFR-2 are expressed at mid-luteal stages in luteal cells of corpus luteum; galectin-1 (显示 LGALS1 ELISA试剂盒) binds directly to asparagine-linked glycans (N-glycans) on VEGFR-2 in luteal cells.
MMP-1 (显示 MMP1 ELISA试剂盒) promotes VEGFR2 expression and proliferation of endothelial cells through stimulation of PAR-1 (显示 F2R ELISA试剂盒) and activation of NF-kappaB (显示 NFKB1 ELISA试剂盒)
Vascular endothelial growth factor receptor-2 activates ADP-ribosylation factor 1 (显示 ARF1 ELISA试剂盒) to promote endothelial nitric-oxide synthase (显示 NOS3 ELISA试剂盒) activation and nitric oxide release from endothelial cells
VEGFR2 mRNA expression was higher at the mid and late luteal stages than at the early I and early II luteal stages, and VEGFR2 protein was higher at the mid and late luteal stages than at estrus (P<0.05)
Alterations in the expression of VEGF-A (显示 VEGFA ELISA试剂盒) and bFGF (显示 FGF2 ELISA试剂盒) systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.
involved in sphingosine 1-phosphate-stimulated phosphorylation of Akt (显示 AKT1 ELISA试剂盒) and endothelial nitric-oxide synthase (eNOS (显示 NOS3 ELISA试剂盒))
Placenta growth factor (显示 PGF ELISA试剂盒) expression is regulated by both VEGF (显示 VEGFA ELISA试剂盒) and hyperglycaemia via VEGFR-2.
ghrelin (显示 GHRL ELISA试剂盒) can inhibit intraplaque angiogenesis and promote plaque stability by down-regulating VEGF (显示 VEGFA ELISA试剂盒) and VEGFR2 expression, inhibiting the plaque content of macrophages, and reducing MCP-1 (显示 CCL2 ELISA试剂盒) expression at an advanced stage of atherosclerosis in rabbits
Antenatal intratracheal VEGF (显示 VEGFA ELISA试剂盒) administration was associated with an increase in Flk-1 immunoreactivity.
Intronic Flk1 genetic enhancer element directs arterial-specific expression via RBPJ (显示 RBPJ ELISA试剂盒)-mediated venous repression.
Ca(2 (显示 CA2 ELISA试剂盒)+) oscillations depended upon VEGF receptor-2 (Vegfr2) and Vegfr3 (显示 FLT4 ELISA试剂盒) in endothelial cells budding from the dorsal aorta (DA) and posterior cardinal (显示 CARD8 ELISA试剂盒) vein, respectively.
Methylglyoxal acts on smaller blood vessels in zebrafish via the VEGF receptor (显示 FLT1 ELISA试剂盒) signaling cascade, thereby describing a new mechanism that can explain vascular complications under hyperglycemia and elevated MG concentrations.
methylation of Lys (显示 LYZ ELISA试剂盒)(1041) promotes the activation of VEGFR-2 and that similar posttranslational modification could also regulate the activity of other receptor tyrosine kinases.
Perturbation of the HSP70 (显示 HSPA1A ELISA试剂盒)-HSP90 (显示 HSP90 ELISA试剂盒) heat-shock protein axis stimulates degradation of endothelial VEGFR2.
Data indicate that the increase in FLT1/sFLT1 (显示 FLT1 ELISA试剂盒) protein levels upon miR-10 (显示 LILRB2 ELISA试剂盒) knockdown inhibited the angiogenic behavior of endothelial cells largely by antagonizing vascular endothelial growth factor receptor 2 signaling: [miR10 (显示 LILRB2 ELISA试剂盒)]
Early Flk1 expression may be induced by cooperative interactions between Gata (显示 GATA4 ELISA试剂盒), Tcf (显示 HNF4A ELISA试剂盒)/Lef, Cdx (显示 CDX1 ELISA试剂盒) and ER71/Etv2 under the control of Bmp, Wnt (显示 WNT2 ELISA试剂盒) and Fgf signaling.
Using 2 distinct pharmacologic VEGFR2 inhibitors the study shows that rap1b (显示 RAP1A ELISA试剂盒) and VEGFR2 act additively to control angiogenesis in vivo.
Data show that flk1 is not required for proper vasculogenesis and hematopoiesis in zebrafish embryos; however, the disruption of flk1 impairs the formation or function of vessels generated by sprouting angiogenesis
flk1 is a direct target of FoxH1 (显示 FOXH1 ELISA试剂盒); FoxH1 (显示 FOXH1 ELISA试剂盒) is involved in vessel formation in zebrafish.
Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas.
vascular endothelial growth factor receptor 2
, VEGF receptor-2
, fetal liver kinase 1
, kinase NYK
, protein-tyrosine kinase receptor flk-1
, soluble vascular endothelial growth factor receptor 2
, vascular endothelial growth factor receptor- 2
, vascular endothelial growth factor receptor-2
, vascular endothelial growth factor receptor-3
, FLK1 kinase insert domain receptor (VEGF receptor 2)
, FLK1 kinase insert domain receptor (a type III receptor tyrosine kinase) (VEGF receptor 2)
, kinase insert domain protein receptor
, fetal liver kinase-1
, protein-tyrosine kinase receptor Flk-1
, soluble VEGFR2
, tyrosine kinase growth factor receptor
, flk-1 type VEGF receptor
, flk-1 receptor
, protein-tyrosine kinase
, tyrosine kinase receptor
, VEGF receptor-2/Flk-1
, VEGFR-2 homolog B
, fetal liver kinase 1b
, kinase insert domain receptor (a type III receptor tyrosine kinase), b
, kinase insert domain receptor-B
, protein-tyrosine kinase receptor flk-1b
, vascular endothelial growth factor receptor 2 homolog B
, kinase insert domain receptor-A
, kinase insert domain receptor-like
, vascular endothelial growth factor receptor 4
, vascular endothelial growth factor receptor kdr-like
, vascular endothelial growth factor receptor type 2