anti-TSC2 (TSC2) 抗体产品概述

Full name:
anti-Tuberous Sclerosis 2 抗体 (TSC2)
在www.antibodies-online.cn可供746 Tuberous Sclerosis 2 (TSC2) 抗体的25不同的供货商。 再加上,我们可以发TSC2 试剂盒 (14)和数多这个蛋白质的别的产品。 总共783 TSC2产品已列进来了。
别名:
fc16b02, LAM, Nafld, Rc, Tcs2, TSC2, TSC4, tuberin, wu:fc16b02

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引用最多的anti-TSC2 抗体

  1. Human Polyclonal TSC2 Primary Antibody for DB, IF - ABIN1881949 : Li, Inoki, Guan: Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity. in Molecular and cellular biology 2004 (PubMed)
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  2. Human Polyclonal TSC2 Primary Antibody for EIA - ABIN358411 : Karbowniczek, Cash, Cheung, Robertson, Astrinidis, Henske: Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent. in The Journal of biological chemistry 2004 (PubMed)
    Show all 5 references for 358411

  3. Human Polyclonal TSC2 Primary Antibody for DB, EIA - ABIN358369 : Corradetti, Inoki, Bardeesy, DePinho, Guan: Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. in Genes & development 2004 (PubMed)
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  4. Human Polyclonal TSC2 Primary Antibody for DB, EIA - ABIN358410 : Birchenall-Roberts, Fu, Bang, Dambach, Resau, Sadowski, Bertolette, Lee, Kim, Ruscetti: Tuberous sclerosis complex 2 gene product interacts with human SMAD proteins. A molecular link of two tumor suppressor pathways. in The Journal of biological chemistry 2004 (PubMed)
    Show all 5 references for 358410

  5. Human Polyclonal TSC2 Primary Antibody for EIA - ABIN358353 : Lewis, Thomas, Murphy, Sampson: Genotype and psychological phenotype in tuberous sclerosis. in Journal of medical genetics 2004 (PubMed)
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  6. Human Polyclonal TSC2 Primary Antibody for DB - ABIN1881948 : Dántola, Denofrio, Zurbano, Gimenez, Ogilby, Lorente, Thomas: Mechanism of photooxidation of folic acid sensitized by unconjugated pterins. in Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2010 (PubMed)
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  7. Human Polyclonal TSC2 Primary Antibody for WB - ABIN1881945 : Larson, Liu, Stevens, Li, Li, Evers, Gao: Tuberous sclerosis complex 2 (TSC2) regulates cell migration and polarity through activation of CDC42 and RAC1. in The Journal of biological chemistry 2010 (PubMed)
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  8. Human Polyclonal TSC2 Primary Antibody for ELISA, WB - ABIN1533200 : : Identification and characterization of the tuberous sclerosis gene on chromosome 16. in Cell 1994 (PubMed)
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  9. Human Polyclonal TSC2 Primary Antibody for IHC, ELISA - ABIN1532185 : Xu, Sterner, Maheshwar, Wilson, Nellist, Short, Haines, Sampson, Ramesh: Alternative splicing of the tuberous sclerosis 2 (TSC2) gene in human and mouse tissues. in Genomics 1995 (PubMed)
    Show all 2 references for 1532185

  10. Human Polyclonal TSC2 Primary Antibody for IF (p), IHC (p) - ABIN701200 : Wang, Chen, Deng, Bian, Huang, Lei, Lv, Liu, Li: Repression of TSC1/TSC2 mediated by MeCP2 regulates human embryo lung fibroblast cell differentiation and proliferation. in International journal of biological macromolecules 2017 (PubMed)

更多抗TSC2的相互作用对抗体

Zebrafish Tuberous Sclerosis 2 (TSC2) interaction partners

  1. This is the first report using an animal model to show interactions between tsc2, mTORC1 and p53 (显示 TP53 抗体) during tumorigenesis.

  2. These results demonstrate a highly conserved role of tsc2 in zebrafish and establish a new animal model for studies of Tuberous sclerosis complex.

Human Tuberous Sclerosis 2 (TSC2) interaction partners

  1. Novel missense mutation in the exon 19 of the TSC2 gene is associated with tuberous sclerosis.

  2. our findings suggest the significance of previously undocumented mutation-dependent mTOR (显示 FRAP1 抗体) hyperactivation and frequent TSC1 (显示 TSC1 抗体)/2 mutations in HBV-associated HCCs (显示 HCCS 抗体). They define a molecular subset of HCC (显示 FAM126A 抗体) having genetic aberrations in mTOR (显示 FRAP1 抗体) signalling, with potential significance of effective specific drug therapy.

  3. Mutation in TSC2 is associated with lymphangioleiomyomatosis.

  4. Results show that tuberous sclerosis complex disease segregates with a silent substitution in TSC2, c.4149C>T, p.(Ser1838Ser), which leads to the formation of an active donor splice site, resulting in three shorter alternatively spliced transcripts with premature stop codons.

  5. Clinical whole exome sequencing of blood and tumor samples con (显示 DISP1 抗体) fi rmed the diagnosis of methylmalonic acidemia and revealed two somatic inactivating mutations in TSC2, suggesting the potential consideration of an mTOR (显示 FRAP1 抗体) inhibitor in the event of tumor recurrence.

  6. TSC2 N-terminal lysine acetylation status affects to its stability modulating mTORC1 signaling and autophagy/cell proliferation.

  7. The mTOR (显示 FRAP1 抗体)-dependent, epithelial phenotype of TSC (显示 SLC12A3 抗体) astrocytes suggests TSC1 (显示 TSC1 抗体)/2 and mTOR (显示 FRAP1 抗体) tune the phosphorylation level of catenin delta-1 (显示 CTNND1 抗体) by controlling PKCe (显示 PRKCE 抗体) activity, thereby regulating the mesenchymal-epithelial-transition (MET)

  8. TSC2 mutations leading to severe tuberous sclerosis in Chinese children.

  9. Our results indicate that TSC2 and less commonly TSC1 (显示 TSC1 抗体) alterations are the primary essential driver event in angiomyolipoma/Lymphangioleiomyomatosis, whereas other somatic mutations are rare and likely do not contribute to tumor development.

  10. These results suggested that TSC2 heterozygosity caused neurological malformations in primitive neural stem cells, indicating that its heterozygosity might be sufficient for the development of neurological abnormalities in patients.

Mouse (Murine) Tuberous Sclerosis 2 (TSC2) interaction partners

  1. Tsc2-mTOR (显示 FRAP1 抗体) signaling in mesenchyme is essential for the maintenance of renal structure and for lung alveolarization.

  2. TSC1 (显示 TSC1 抗体)/TSC2 complex upregulation of OPN (显示 SPP1 抗体) expression is mediated by transcription factor SOX9 (显示 SOX9 抗体) in an mTOR (显示 FRAP1 抗体)-independent manner. Moreover, ablation of OPN (显示 SPP1 抗体) by deficient TSC1 (显示 TSC1 抗体)/TSC2 complex contributed to inactivation of AKT (显示 AKT1 抗体) in TSC (显示 SLC12A3 抗体) cells

  3. Rheb (显示 RHEB 抗体) and TSC2 have roles in the mechanical activation of mTOR (显示 FRAP1 抗体) signaling

  4. this study shows that TSC2 maintains macrophage quiescence and prevents mTORC1-dependent granulomatous disease with clinical implications for sarcoidosis

  5. TSC2 N-terminal lysine acetylation status affects to its stability modulating mTORC1 signaling and autophagy/cell proliferation.

  6. Repression of TSC1 (显示 TSC1 PLURAL_@4252@)/TSC2 mediated by MeCP2 (显示 MECP2 PLURAL_@4252@) regulates human embryo lung fibroblast cell differentiation and proliferation.

  7. Formation of ROS (显示 ROS1 抗体) and activity of NADPH (显示 FDXR 抗体) oxidases were significantly higher in mouse embryonic fibroblasts and in primary culture of rat renal proximal tubular epithelial tuberin-deficient cells compared to wild-type cells.

  8. Data suggest that pathological cardiac hypertrophy involved class I histone deacetylases HDAC1 (显示 HDAC1 抗体) and HdAC2 (显示 HDAC2 抗体), tuberous sclerosis complex 2 (TSC2), and mTOR (显示 FRAP1 抗体) srine-threonine kinases (mTOR (显示 FRAP1 抗体)).

  9. autophagy via the TSC2-mTORC1 signaling pathway plays an important role in maintenance of cardiac function and mitochondrial quantity and size in the heart.

  10. PAK2 (显示 PAK2 抗体) is a direct effector of TSC1 (显示 TSC1 抗体)-TSC2-RHEB (显示 RHEB 抗体) signaling and a new target for rational drug therapy in TSC (显示 SLC12A3 抗体).

Pig (Porcine) Tuberous Sclerosis 2 (TSC2) interaction partners

  1. Porcine circovirus type 2 (PCV2) might induce autophagy via the AMPK (显示 PRKAA1 抗体)/ERK (显示 MAPK1 抗体)/TSC2/mTOR (显示 FRAP1 抗体) signaling pathway in the host cells, representing a pivotal mechanism for PCV2 pathogenesis

Cow (Bovine) Tuberous Sclerosis 2 (TSC2) interaction partners

  1. prostaglandin F2alpha phosphorylates TSC2 and activates mTOR (显示 FRAP1 抗体) and ribosomal protein S6 (显示 RPS6 抗体) kinase (显示 RPS6KB1 抗体) signaling in an AKT (显示 AKT1 抗体)-independent manner

TSC2 抗原简介

Antigen Summary

Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms.

Alternative names and synonyms associated with TSC2

  • tuberous sclerosis 2 (TSC2) 抗体
  • tuberous sclerosis complex 2 (TSC2) (AaeL_AAEL007712) 抗体
  • tuberous sclerosis 2 (tsc2) 抗体
  • tuberous sclerosis 2 (PGTG_00159) 抗体
  • tuberous sclerosis 2 (Tsc2) 抗体
  • fc16b02 抗体
  • LAM 抗体
  • Nafld 抗体
  • Rc 抗体
  • Tcs2 抗体
  • TSC2 抗体
  • TSC4 抗体
  • tuberin 抗体
  • wu:fc16b02 抗体

Protein level used designations for anti-Tuberous Sclerosis 2 (TSC2) 抗体

tuberous sclerosis complex 2 (TSC2) , tuberous sclerosis 2 , tuberin-like , tuberin , tuberous sclerosis 2 protein , tuberous sclerosis 2 protein homolog , renal carcinoma , tuberous sclerosis 2 homolog protein

GENE ID SPECIES
100065679 Equus caballus
5569538 Aedes aegypti
468086 Pan troglodytes
567524 Danio rerio
694965 Macaca mulatta
10528144 Puccinia graminis f. sp. tritici CRL 75-36-700-3
100170546 Xenopus (Silurana) tropicalis
100390664 Callithrix jacchus
7249 Homo sapiens
22084 Mus musculus
24855 Rattus norvegicus
479883 Canis lupus familiaris
100505408 Sus scrofa
504985 Bos taurus
416552 Gallus gallus
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