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High SHC3 expression is associated with glioblastoma.
Rai (ShcC/N-Shc), a member of the family of Shc (显示 SHC1 ELISA试剂盒)-like adaptor proteins, as a new regulator of migration of normal and cancer stem/progenitor cells.
Polymorphism in RAI and CD3EAP are associated with outcome of myeloma patients treated with high dose treatment.
amplification of SHC3 and EDG3 (显示 S1PR3 ELISA试剂盒) genes suggests that the two proteins co-operate and are important for ependymomas in vivo.
Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc (显示 SHC1 ELISA试剂盒).
ALK (显示 ALK ELISA试剂盒)-ShcC signal activation, possibly caused by co-amplification with the N-myc (显示 MYCN ELISA试剂盒) gene, might give additional effects on malignant tumor progression of neuroblastoma.ShcC is a potent substrate of the activated ALK (显示 ALK ELISA试剂盒) kinase.
The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret (显示 RET ELISA试剂盒) to the phosphatidylinositol 3-kinase/Akt (显示 AKT1 ELISA试剂盒) signaling pathway.
ShcC has phosphotyrosine-dependent and -independent functions in neuroblastoma (显示 ARHGEF16 ELISA试剂盒) cells
The inappropriate in vivo expression of Shc3 in high-grade glioma may contribute to the survival of the cancer cells.
data suggest that RAI (ShcC/H-Shc (显示 SHC1 ELISA试剂盒))is a critical substrate for RET (显示 RET ELISA试剂盒) oncoproteins in thyroid carcinomas
The results provide evidence that Rai/ShcC plays opposite roles in Th17 cell differentiation and astrocyte activation
Rai interferes with the TCR signaling cascade one of the earliest steps--recruitment of the initiating kinase ZAP-70 (显示 ZAP70 ELISA试剂盒) to the phosphorylated subunit of the TCR/CD3 (显示 CD3E ELISA试剂盒) complex.
TrkB (显示 NTRK2 ELISA试剂盒)-mediated ERK1/2 (显示 MAPK1/3 ELISA试剂盒) activation is impaired in huntingtin (显示 HTT ELISA试剂盒) knock-in striatal cells involves reduced p52/p46 (显示 POLDIP3 ELISA试剂盒) Shc (显示 SHC1 ELISA试剂盒) expression
binds the Trk (显示 NTRK1 ELISA试剂盒) receptors in a phosphotyrosine-dependent manner via their N-terminal phosphotyrosine binding domain
Rai has a functional neuroprotective role in brain injury, with possible implications in the treatment of stroke
ShcC mediates TrkB (显示 NTRK2 ELISA试剂盒)-Ras/MAPK (显示 MAPK1 ELISA试剂盒) signaling & regulates NMDA receptor function in the hippocampus via interaction with phosphotyrosines on the receptor subunits. It serves as a modulator of hippocampal synaptic plasticity underlying learning & memory.
Expressed in T and B cells; loss of Rai results in breaking of immunological tolerance and development of systemic autoimmunity.
may be involved in brain-derived neurotrophic factor signalling during retinal development
SH2 domain protein C3
, SHC-transforming protein 3
, SHC-transforming protein C
, neuronal Shc
, protein Rai
, src homology 2 domain-containing transforming protein C3
, src homology 2 domain-containing-transforming protein C3