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Mutation in PPP3CA gene is associated with Severe Neurodevelopmental Disease with Seizures.
identify a distinct C-terminal autoinhibitory four-residue sequence in CNAbeta1, (462)LAVP(465), which competitively inhibits substrate dephosphorylation. In vitro and cell-based assays revealed that the CNAbeta1-containing holoenzyme, CNbeta1, is autoinhibited at a single site by either of two inhibitory regions, CBD (显示 OPN1MW ELISA试剂盒) and LAVP, which block substrate access to the substrate-binding groove.
Studies indicate the importance of the AKAP79 (显示 AKAP5 ELISA试剂盒)/PP2B (显示 CAN ELISA试剂盒)/protein kinase A complex's role in synaptic long-term depression in the CA1 (显示 CA1 ELISA试剂盒) region of the hippocampus.
Ca(2 (显示 CA2 ELISA试剂盒)+)/calcineurin (CaN)/nuclear factor of activated T-cells (NFAT (显示 NFATC1 ELISA试剂盒)) c4 axis is required for neuritin (显示 NRN1 ELISA试剂盒)-induced Kv4.2 (显示 KCND2 ELISA试剂盒) transcriptional expression and potentiation of IA densities in cerebellum granule neurons.
CN-A and nephrin were (显示 CABIN1 ELISA试剂盒) clearly reduced in the kidneys of a 10-year-old boy who had relapsing steroid-resistant nephrotic syndrome (显示 NPHS1 ELISA试剂盒).
that KIF1Bbeta affects mitochondrial dynamics through calcineurin-dependent dephosphorylation of Dynamin-related protein 1 (DRP1 (显示 DNM1L ELISA试剂盒)), causing mitochondrial fission and apoptosis
for Aspergillus fumigatus, activation of macrophage calcineurin-NFAT (显示 NFATC1 ELISA试剂盒) occurs via a phagosomal TLR9 (显示 TLR9 ELISA试剂盒)-dependent and Bruton's tyrosine kinase (显示 BTK ELISA试剂盒)-dependent signalling pathway that is independent of MyD88 (显示 MYD88 ELISA试剂盒)
Data indicate that both nuclear factors of activated T cells (NFATs) motifs partially compete for binding but do not fully displace each other on the calcineurin (Cn) epitope.
Lysosomal calcium signaling regulates autophagy through calcineurin and TFEB.
Human herpesvirus 6B U54 binds the calcineurin (CaN) phosphatase enzyme, causing improper dephosphorylation and nuclear translocation of NFAT (显示 NFATC1 ELISA试剂盒) (nuclear factor of activated T cells) proteins, resulting in suboptimal IL-2 (显示 IL2 ELISA试剂盒) gene transcription.
these results demonstrate that increased susceptibility to Aspergillus fumigatus is dependent on calcineurin signaling in myeloid cells
the CaN-Nfat (显示 NFATC1 ELISA试剂盒) pathway regulates development and function of IFN-gamma (显示 IFNG ELISA试剂盒)-producing gammadelta T cells.
the expression of the full-length 60-kDa calcineurin protein is down-regulated due to over-activated calpain that cleaves calcineurin to form a 45-kDa fragment.
AKAP150-calcineurin signaling dyad is essential for the activation of the phosphatase and the subsequent down-regulation of Kv channel currents following myocardial infarction.
Calcineurin inhibitor (显示 RCAN1 ELISA试剂盒) tacrolimus ameliorated proteinuria in nephrotic model by inhibiting the redistribution of CN-A and nephrin (显示 NPHS1 ELISA试剂盒) at the slit diaphragm.
global deficiency of catalytic subunit Ppp3cb (显示 PPP3CB ELISA试剂盒), and tissue-specific ablation of regulatory subunit Ppp3r1 (显示 PPP3R1 ELISA试剂盒) from skeletal muscle, but not adipose tissue or liver, led to protection from high-fat-diet-induced obesity
Overexpression of the phosphatase calcineurin A prevents the development of a capillary/myocyte mismatch despite progressive myocardial hypertrophy.
Catalytic subunits of the phosphatase calcineurin interact with NF-kappaB (显示 NFKB1 ELISA试剂盒)-inducing kinase (NIK (显示 MAP4K4 ELISA试剂盒)) and attenuate NIK (显示 MAP4K4 ELISA试剂盒)-dependent gene expression
Data indicate that calcineurin (CnAalpha-/- or CnAbeta (显示 PPP3CB ELISA试剂盒)-/-) is required for pathological but not compensatory renal hypertrophy.
The calmodulin binding region from residues 389 to 420 was modeled based on the structure of two other proteins having calmodulin binding domains with the same 1-8-14 structural motif as calcineurin.
catalytic subunit of Calcineurin (CaN), ubiquitously expressed Ca2+/CaM-dependent protein phosphatase\; mediates activities of transcription factors and ion channels\; involved in regulation of T-cell activation
CAM-PRP catalytic subunit
, calcineurin A alpha
, calmodulin-dependent calcineurin A subunit alpha isoform
, protein phosphatase 2B, catalytic subunit, alpha isoform
, protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform
, serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
, PP2B alpha 1
, PP2BA alpha
, protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha)
, protein phosphatase 3, catalytic subunit, alpha isoform
, Calcineurin subunit A alpha
, protein phosphatase-2Ba
, calcineurin catalytic subunit delta isoform
, calcineurin catalytic subunit
, protein phosphatase 3, catalytic subunit, alpha isozyme
, serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like