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抗Human PPP3CA 抗体:
抗Mouse (Murine) PPP3CA 抗体:
抗Rat (Rattus) PPP3CA 抗体:
Chicken Monoclonal PPP3CA Primary Antibody for IF, IP - ABIN967862
Jicha, Weaver, Lane, Vianna, Kress, Rockwood, Davies: cAMP-dependent protein kinase phosphorylations on tau in Alzheimer's disease. in The Journal of neuroscience : the official journal of the Society for Neuroscience 1999
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Chicken Monoclonal PPP3CA Primary Antibody for IF, IP - ABIN967861
Liang, Venema, Wang, Ju, Venema, Marrero: Regulation of angiotensin II-induced phosphorylation of STAT3 in vascular smooth muscle cells. in The Journal of biological chemistry 1999
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Human Monoclonal PPP3CA Primary Antibody for IP, WB - ABIN967510
Fruman, Klee, Bierer, Burakoff: Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A. in Proceedings of the National Academy of Sciences of the United States of America 1992
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Human Monoclonal PPP3CA Primary Antibody for IF, IHC (p) - ABIN519132
Totzeck, Boengler, van de Sand, Konietzka, Gres, Garcia-Dorado, Heusch, Schulz: No impact of protein phosphatases on connexin 43 phosphorylation in ischemic preconditioning. in American journal of physiology. Heart and circulatory physiology 2008
Mutation in PPP3CA gene is associated with Severe Neurodevelopmental Disease with Seizures.
identify a distinct C-terminal autoinhibitory four-residue sequence in CNAbeta1, (462)LAVP(465), which competitively inhibits substrate dephosphorylation. In vitro and cell-based assays revealed that the CNAbeta1-containing holoenzyme, CNbeta1, is autoinhibited at a single site by either of two inhibitory regions, CBD (显示 OPN1MW 抗体) and LAVP, which block substrate access to the substrate-binding groove.
Studies indicate the importance of the AKAP79 (显示 AKAP5 抗体)/PP2B/protein kinase A complex's role in synaptic long-term depression in the CA1 (显示 CA1 抗体) region of the hippocampus.
Ca(2 (显示 CA2 抗体)+)/calcineurin (CaN)/nuclear factor of activated T-cells (NFAT (显示 NFATC1 抗体)) c4 axis is required for neuritin (显示 NRN1 抗体)-induced Kv4.2 (显示 KCND2 抗体) transcriptional expression and potentiation of IA densities in cerebellum granule neurons.
CN-A and nephrin were (显示 CABIN1 抗体) clearly reduced in the kidneys of a 10-year-old boy who had relapsing steroid-resistant nephrotic syndrome (显示 NPHS1 抗体).
that KIF1Bbeta affects mitochondrial dynamics through calcineurin-dependent dephosphorylation of Dynamin-related protein 1 (DRP1 (显示 DNM1L 抗体)), causing mitochondrial fission and apoptosis
for Aspergillus fumigatus, activation of macrophage calcineurin-NFAT (显示 NFATC1 抗体) occurs via a phagosomal TLR9 (显示 TLR9 抗体)-dependent and Bruton's tyrosine kinase (显示 BTK 抗体)-dependent signalling pathway that is independent of MyD88 (显示 MYD88 抗体)
Data indicate that both nuclear factors of activated T cells (NFATs) motifs partially compete for binding but do not fully displace each other on the calcineurin (Cn) epitope.
Lysosomal calcium signaling regulates autophagy through calcineurin and TFEB (显示 TFEB 抗体).
Human herpesvirus 6B U54 binds the calcineurin (CaN) phosphatase enzyme, causing improper dephosphorylation and nuclear translocation of NFAT (显示 NFATC1 抗体) (nuclear factor of activated T cells) proteins, resulting in suboptimal IL-2 (显示 IL2 抗体) gene transcription.
these results demonstrate that increased susceptibility to Aspergillus fumigatus is dependent on calcineurin signaling in myeloid cells
the CaN-Nfat (显示 NFATC1 抗体) pathway regulates development and function of IFN-gamma (显示 IFNG 抗体)-producing gammadelta T cells.
the expression of the full-length 60-kDa calcineurin protein is down-regulated due to over-activated calpain that cleaves calcineurin to form a 45-kDa fragment.
AKAP150-calcineurin signaling dyad is essential for the activation of the phosphatase and the subsequent down-regulation of Kv channel currents following myocardial infarction.
Calcineurin inhibitor (显示 RCAN1 抗体) tacrolimus ameliorated proteinuria in nephrotic model by inhibiting the redistribution of CN-A and nephrin (显示 NPHS1 抗体) at the slit diaphragm.
global deficiency of catalytic subunit Ppp3cb (显示 PPP3CB 抗体), and tissue-specific ablation of regulatory subunit Ppp3r1 (显示 PPP3R1 抗体) from skeletal muscle, but not adipose tissue or liver, led to protection from high-fat-diet-induced obesity
Overexpression of the phosphatase calcineurin A (显示 CAN 抗体) prevents the development of a capillary/myocyte mismatch despite progressive myocardial hypertrophy.
Catalytic subunits of the phosphatase calcineurin interact with NF-kappaB (显示 NFKB1 抗体)-inducing kinase (NIK (显示 MAP4K4 抗体)) and attenuate NIK (显示 MAP4K4 抗体)-dependent gene expression
Data indicate that calcineurin (CnAalpha-/- or CnAbeta (显示 PPP3CB 抗体)-/-) is required for pathological but not compensatory renal hypertrophy.
The calmodulin binding region from residues 389 to 420 was modeled based on the structure of two other proteins having calmodulin binding domains with the same 1-8-14 structural motif as calcineurin.
catalytic subunit of Calcineurin (CaN), ubiquitously expressed Ca2+/CaM-dependent protein phosphatase\; mediates activities of transcription factors and ion channels\; involved in regulation of T-cell activation
CAM-PRP catalytic subunit
, calcineurin A alpha
, calmodulin-dependent calcineurin A subunit alpha isoform
, protein phosphatase 2B, catalytic subunit, alpha isoform
, protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform
, serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
, PP2B alpha 1
, PP2BA alpha
, protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha)
, protein phosphatase 3, catalytic subunit, alpha isoform
, Calcineurin subunit A alpha
, protein phosphatase-2Ba
, calcineurin catalytic subunit delta isoform
, calcineurin catalytic subunit
, protein phosphatase 3, catalytic subunit, alpha isozyme
, serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like