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Human Monoclonal NFATC1 Primary Antibody for IF, IP - ABIN967559
Crabtree: Contingent genetic regulatory events in T lymphocyte activation. in Science (New York, N.Y.) 1989
Show all 5 Pubmed References
Hamster Monoclonal NFATC1 Primary Antibody for ChIP, GS - ABIN152773
Alpini, Franchitto, Demorrow, Onori, Gaudio, Wise, Francis, Venter, Kopriva, Mancinelli, Carpino, Stagnitti, Ueno, Han, Meng, Glaser: Activation of alpha(1) -adrenergic receptors stimulate the growth of small mouse cholangiocytes via calcium-dependent activation of nuclear factor of activated T cells 2 and specificity protein 1. in Hepatology (Baltimore, Md.) 2011
Transplantation from GRIM19 (显示 NDUFA13 抗体)-overexpressing cells downregulated the expression of nuclear factor of activated T cells (NFATc1) but promoted the expression of regulator of calcineurin (RCAN)3 (显示 RCAN3 抗体) while downregulating NFAT-dependent cytokine gene expression.
These results suggest that the Keap1 (显示 KEAP1 抗体)/Nrf2 (显示 NFE2L2 抗体) axis plays a critical role in NFATc1 expression and osteoclastogenic progression.
Inhibition of calcineurin activity with FK506 or blockage of L-type calcium channels with nifedipine significantly suppressed NFATc1 mRNA expression and CTSK (显示 CTSK 抗体) protein expression.
astrocytes were strongly associated with proteolysis of the protein phosphatase calcineurin (CN) and the elevated expression of the CN-dependent transcription factor nuclear factor of activated T cells 4 (NFAT4 (显示 NFATC3 抗体)
In studies of human and mouse pancreatic cells and tissue, we identified context-specific epigenetic regulation of NFATc1 activity as an important mechanism of pancreatic cell plasticity.
Immunoreceptor tyrosine-based inhibitory motif DC-STAMP (显示 TM7SF4 抗体) is a functional motif that regulates osteoclast differentiation through the NFATc1/Ca(2 (显示 CA2 抗体)+) axis.
TNF (显示 TNF 抗体)/IL-6 (显示 IL6 抗体) generated osteoclasts in vitro that resorbed mineralized tissue through a pathway dependent on IL-6R, NFATc1, DNAX-activation protein 12 (显示 TYROBP 抗体), and cell proliferation.
PRIP (显示 NCOA6 抗体) deficiency impairs osteoclast differentiation, particularly at the early stages, and PRIP (显示 NCOA6 抗体) stimulates osteoclast differentiation through calcium-calcineurin-NFATc1 signaling via regulating intracellular Ca(2 (显示 CA2 抗体)+)
Results suggest that 25-hydroxycholesterol (25-HC) induced the interaction between NFATc1 and Sp1 (显示 SP1 抗体), reducing the level of free Sp1 (显示 SP1 抗体) to inhibit microRNA miR (显示 MLXIP 抗体)-139-5p expression and promote osteoclastogenesis.
In summary, gastrodin could prevent osteoclasts formation and bone resorption via blockage of NFATc1 activity, and stimulate osseointegration in vitro. Gastrodin could be developed as a potent phytochemical candidate to treat osteolytic diseases.
Pathway analysis of the genes associated with the 46 CpG sites revealed an enrichment of immune system process genes, including LYST (显示 LYST 抗体) (cg16962115, FDR = 1.24E-04), CADM1 (显示 CADM1 抗体) (cg21933078, FDR = 1.22E-02) and NFATC1 (cg06784563, FDR = 1.46E-02)
there is an NFATc1/ABCA1 (显示 ABCA1 抗体)-dependent mechanism in which local TNF (显示 TNF 抗体) is sufficient to cause free cholesterol-dependent podocyte injury irrespective of TNF (显示 TNF 抗体), TNFR1 (显示 TNFRSF1A 抗体), or TNFR2 (显示 TNFRSF1B 抗体) serum levels
NFATC1 transcription factor (NFATc1) expression is detected in prostate cancer (PCa (显示 FLVCR1 抗体)) specimens and PCa (显示 FLVCR1 抗体) cells but is absent in non-neoplastic human prostates and non-tumorigenic prostatic cells
DYRK1A phosphorylation of NFATc1/alphaA at S261, S278, S403 and S409 interfered with NFATc1 ubiquitination and ubiquitin-proteasome degradation.
NFATC1 rs3894049 GC was a risk factor for acute rejection in renal transplant recipients compared with CC carriers.
revealed more than 170 NFAT-associated proteins, half of which are involved in transcriptional regulation. Among them are many hitherto unknown interaction partners of NFATc1 and NFATc2 (显示 NFAT1 抗体) in T cells, such as Raptor (显示 RPTOR 抗体), CHEK1 (显示 CHEK1 抗体), CREB1 (显示 CREB1 抗体), RUNX1 (显示 RUNX1 抗体), SATB1 (显示 SATB1 抗体), Ikaros (显示 IKZF1 抗体), and Helios (显示 ZNFN1A2 抗体).
NFATc1 silencing regulates the cell cycle.
Study showed that luteolin and apigenin effectively maintain pluripotency of PDLCs through activation of Oct-4 (显示 POU5F1 抗体)/Sox2 (显示 SOX2 抗体) signal via NFATc1.
The enhanced osteoclast formation by TECK (显示 CCL25 抗体) was mediated by NFATc1, but not by NF-kB signaling.
In calf pulmonary artery endothelial cells, extracellular application of vasoactive agonist ATP or calcium ionophore ionomycin generates a rise in intracellular calcium that induces nuclear localization of NFATc1.
regulation of nuclear localization of NFAT is isoform-specific and dependent on nuclear export processes
The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes.
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
, nuclear factor of activated T-cells, cytosolic component 1
, nuclear factor of activated T-cells calcineurin-dependent 1
, nuclear factor of activated T-cells, cytoplasmic 1
, nuclear factor of activated T-cells, cytoplasmic 1-like
, NFAT transcription complex cytosolic component
, transcription factor NF-ATc
, transcription factor NFATmac