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Data, including data from studies in transgenic/knockout mice, suggest expression of Gab1/Gab2 (显示 GAB2 抗体) is up-regulated in activated macrophages in pulmonary fibrosis; both Gab1/Gab2 (显示 GAB2 抗体) are recruited to Il4r (显示 IL4R 抗体), synergistically enhancing downstream signal amplification. (Gab1 = growth factor receptor bound protein 2-associated protein 1; Gab2 (显示 GAB2 抗体) = growth factor receptor bound protein 2-associated protein 2 (显示 GAB2 抗体); Il4r (显示 IL4R 抗体) = interleukin-4 receptor (显示 IL4R 抗体))
these findings suggest that the striated (显示 NSDHL 抗体) muscle-specific (显示 EIF3K 抗体) high-MW isoform of Gab1 has a crucial role for NRG-1 (显示 NRG1 抗体)/ErbB (显示 EGFR 抗体) signaling in cardiomyocytes.
These findings provide the direct evidence about the roles of docking protein Gab1 in lungs.
These results demonstrate that cardiomyocyte Gab1 is a critical regulator of the compensatory cardiac response to aging and hemodynamic stress.
Gab1 is essential regulator of the hair cycle and the self-renewal of hair follicle stem cells.
Data show that guanine nucleotide-binding protein G(i) subunit alpha-1 and alpha-3 (Galphai1/3) can interact with CD14 antigen/Grb2-associated binding protein Gab1, which modulates macrophage polarization in vitro and in vivo.
Hepatocyte Gab1 is required for liver fibrosis and that hepatocyte CCL5 (显示 CCL5 抗体) could be an important contributor to this process.
endothelial Gab1 signaling inhibited splenomegaly in portal hypertension independent of angiogenesis.
Suggest that Gab1 is essential for cardioprotection against ischemia reperfusion oxidative injury, mediating survival signaling.
These results establish the Frs2alpha-Shp2 complex as the key mediator of FGF signaling in lens development
The model showed agreement at several key nodes, involving scaffolding proteins Gab1, Gab2 (显示 GAB2 抗体) and their complexes with Shp2 (显示 PTPN11 抗体). VEGFR2 (显示 KDR 抗体) recruitment of Gab1 is greater in magnitude, slower, and more sustained than that of Gab2 (显示 GAB2 抗体). As Gab2 (显示 GAB2 抗体) binds VEGFR2 (显示 KDR 抗体) complexes more transiently than Gab1, VEGFR2 (显示 KDR 抗体) complexes can recycle and continue to participate in other signaling pathways.
data suggested that miR (显示 MLXIP 抗体)-141-3p decreased the proliferation and migration of keloid fibroblasts by repressing GAB1 expression, providing a useful target for keloid management
Gab1 expression is correlated with poor prognosis of Epithelial ovarian cancer patients.
these data provide novel information for comprehending the tumor-suppressive role of miR (显示 MLXIP 抗体)-200a in HCC (显示 FAM126A 抗体) pathogenesis through inhibition of GAB1 translation.
Gab1 has a role in regulating SDF-1 (显示 CXCL12 抗体)-induced progression via inhibition of apoptosis pathway induced by PI3K (显示 PIK3CA 抗体)/AKT (显示 AKT1 抗体)/Bcl-2 (显示 BCL2 抗体)/BAX (显示 BAX 抗体) pathway in human chondrosarcoma (CS). Gab1 can be recommended as a novel biomarker for diagnosis and prognosis in patients with CS.
We found that expression of Gab1, VEGFR-2 (显示 KDR 抗体), and MMP-9 (显示 MMP9 抗体) was highly and positively correlated with each other and with lymph node metastasis and TNM (显示 ODZ1 抗体) stage in intrahepatic cholangiocarcinoma tissues
Gab1 protein was upregulated in cyanotic compared to acyanotic hearts suggesting that Gab1 upregulation is a component of the survival program initiated by hypoxia in cyanotic children
CVB3 targets host GAB1 to generate a GAB1-N1-174 fragment that enhances viral infectivity, at least in part, via activation of the ERK (显示 EPHB2 抗体) pathway
EGFR (显示 EGFR 抗体)-activated Src (显示 SRC 抗体) family kinases maintain GAB1-SHP2 (显示 PTPN11 抗体) complexes distal from EGFR (显示 EGFR 抗体).
These data suggest that Gab1-ERK1/2 (显示 MAPK1/3 抗体) binding and their nuclear translocation play a crucial role in Egr-1 (显示 EGR1 抗体) nuclear accumulation.
Gab1 tyrosine phosphorylation is stimulated by flow shear stress to mediate protein kinase B (显示 AKT1 抗体) and endothelial nitric-oxide synthase (显示 NOS3 抗体) activation in endothelial cells
Gab1 is a novel critical regulatory component of endothelial cell migration and capillary formation with a key role in the activation of VEGF-evoked signaling pathways required for angiogenesis
The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene.
GRB2-associated binder 1
, GRB2-associated-binding protein 1
, GRB2-associated binding protein 1 long isoform
, growth factor receptor bound protein 2-associated protein 1